Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis
补体因子B (CFB) 的基因编码变异与肛周克罗恩病风险增加相关,并导致CFB裂解和吞噬功能受损。
期刊:Gut
影响因子:25.8
doi:10.1136/gutjnl-2023-329689
Akhlaghpour, Marzieh; Haritunians, Talin; More, Shyam K; Thomas, Lisa S; Stamps, Dalton T; Dube, Shishir; Li, Dalin; Yang, Shaohong; Landers, Carol J; Mengesha, Emebet; Hamade, Hussein; Murali, Ramachandran; Potdar, Alka A; Wolf, Andrea J; Botwin, Gregory J; Khrom, Michelle; Ananthakrishnan, Ashwin N; Faubion, William A; Jabri, Bana; Lira, Sergio A; Newberry, Rodney D; Sandler, Robert S; Sartor, R Balfour; Xavier, Ramnik J; Brant, Steven R; Cho, Judy H; Duerr, Richard H; Lazarev, Mark G; Rioux, John D; Schumm, L Philip; Silverberg, Mark S; Zaghiyan, Karen; Fleshner, Phillip; Melmed, Gil Y; Vasiliauskas, Eric A; Ha, Christina; Rabizadeh, Shervin; Syal, Gaurav; Bonthala, Nirupama N; Ziring, David A; Targan, Stephan R; Long, Millie D; McGovern, Dermot P B; Michelsen, Kathrin S