Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution
利用定向进化提高细胞色素P450单加氧酶的特异性,实现阿维菌素向4''-氧代阿维菌素的生物催化转化
期刊:Applied and Environmental Microbiology
影响因子:3.7
doi:10.1128/AEM.02676-06
Trefzer, Axel; Jungmann, Volker; Molnár, István; Botejue, Ajit; Buckel, Dagmar; Frey, Gerhard; Hill, D Steven; Jörg, Mario; Ligon, James M; Mason, Dylan; Moore, David; Pachlatko, J Paul; Richardson, Toby H; Spangenberg, Petra; Wall, Mark A; Zirkle, Ross; Stege, Justin T