Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1(+)CD8(+) T cells
CTLA-4检查点疗法的疗效依赖于IL-21信号通路介导PD-1(+)CD8(+) T细胞的细胞毒性重编程。
期刊:Nature Immunology
影响因子:27.6
doi:10.1038/s41590-024-02027-0
Zhang, Zhen; Langenbach, Marlene; Sagar, Sagar; Fetsch, Viktor; Stritzker, Jonas; Severa, Elizabeth; Meng, Ke; Winkler, Frances; Rana, Nisha; Zoldan, Katharina; Godbole, Ira; Solis, Sabrina; Weber, Jeffrey S; Rafei-Shamsabadi, David; Lehr, Saskia; Diehl, Rebecca; Venhoff, Ana Cecilia; Voll, Reinhard E; Buettner, Nico; Neumann-Haefelin, Christoph; Boettler, Tobias; Hofmann, Maike; Boerries, Melanie; Meiss, Frank; Zeiser, Robert; Thimme, Robert; Herati, Ramin S; Bengsch, Bertram
IL-21
T细胞
信号转导
CD8
T细胞
IL-2
细胞生物学
毒理研究
PD-1
免疫/内分泌
