Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions
将与优化的 Toll 样受体 2 配体偶联的 HPV-16 E6 合成肽进行皮内接种,在 HPV-16 阳性(癌前)病变患者中显示出安全性和强大的 T 细胞免疫原性。
期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2022-005016
Speetjens, Frank M; Welters, Marij J P; Slingerland, Marije; van Poelgeest, Mariette I E; de Vos van Steenwijk, Peggy J; Roozen, Inge; Boekestijn, Sanne; Loof, Nikki M; Zom, Gijs G; Valentijn, A Rob P M; Krebber, Willem-Jan; Meeuwenoord, Nico J; Janssen, Catharina A H; Melief, Cornelis J M; van der Marel, Gijs A; Filippov, Dmitri V; van der Burg, Sjoerd H; Gelderblom, Hans; Ossendorp, Ferry