日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages

RSV 融合前 F 蛋白的工程化二酪氨酸键合赋予了稳定性和效力优势

Sonal V Gidwani, Devarshi Brahmbhatt, Aaron Zomback, Mamie Bassie, Jennifer Martinez, Jian Zhuang, John Schulze, Jason S McLellan, Roberto Mariani, Peter Alff, Daniela Frasca, Bonnie B Blomberg, Christopher P Marshall, Mark A Yondola

Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection

尽管病毒完全保护,但当使用 Th2 佐剂(而非 Th1/Th2 平衡佐剂)配制融合前 RSV F 免疫时,小鼠仍会诱发 Th2 介导的肺部病理。

Eichinger, Katherine M; Kosanovich, Jessica L; Gidwani, Sonal V; Zomback, Aaron; Lipp, Madeline A; Perkins, Timothy N; Oury, Tim D; Petrovsky, Nikolai; Marshall, Christopher P; Yondola, Mark A; Empey, Kerry M