The deubiquitylase OTUB1 drives gemcitabine resistance in pancreatic cancer by enhancing pyrimidine metabolism through modulating DHODH mRNA stability.
去泛素化酶 OTUB1 通过调节 DHODH mRNA 的稳定性来增强嘧啶代谢，从而驱动胰腺癌对吉西他滨产生耐药性
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08001-4
Zhang Wenming, Liu Rui, Hu Junwen, Wan Shuangyan, Zou Yeqin, Che Tong, Zhang Jin, Chen Leifeng, Peng Xiaogang
