日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From cholesterol to glucose: uncovering how statins induce β-cell dysfunction to promote type 2 diabetes

从胆固醇到葡萄糖:揭示他汀类药物如何诱导β细胞功能障碍从而促进2型糖尿病的发生

Barrow, Breanne M; Wander, Pandora L; Zraika, Sakeneh

Increased Steroidogenic Acute Regulatory Protein Contributes to Cholesterol-induced β-Cell Dysfunction

类固醇生成急性调节蛋白的增加会导致胆固醇诱导的β细胞功能障碍

Rehana Akter ,Meghan F Hogan ,Nathalie Esser ,Breanne M Barrow ,Joseph J Castillo ,Edward J Boyko ,Andrew T Templin ,Rebecca L Hull ,Sakeneh Zraika ,Steven E Kahn

The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity

胰岛组织纤溶酶原激活剂/纤溶酶系统随着人类胰岛淀粉样多肽聚集而上调,并保护β细胞免受聚集诱导的毒性

Nathalie Esser, Meghan F Hogan, Andrew T Templin, Rehana Akter, Brendy S Fountaine, Joseph J Castillo, Assam El-Osta, Lakshan Manathunga, Alexander Zhyvoloup, Daniel P Raleigh, Sakeneh Zraika, Rebecca L Hull, Steven E Kahn

The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner

新型嵌合多激动剂肽(GEP44)以胰高血糖素样肽-1受体依赖的方式降低饮食诱导肥胖的雄性和雌性小鼠的能量摄入和体重。

Blevins, James E; Honeycutt, Mackenzie K; Slattery, Jared D; Goldberg, Matvey; Rambousek, June R; Tsui, Edison; Dodson, Andrew D; Shelton, Kyra A; Salemeh, Therese S; Elfers, Clinton T; Chichura, Kylie S; Ashlaw, Emily F; Zraika, Sakeneh; Doyle, Robert P; Roth, Christian L

Cystic fibrosis-related diabetes is associated with reduced islet protein expression of GLP-1 receptor and perturbation of cell-specific transcriptional programs

囊性纤维化相关糖尿病与胰岛GLP-1受体蛋白表达降低和细胞特异性转录程序紊乱有关。

Gharib, Sina A; Vemireddy, Rachna; Castillo, Joseph J; Fountaine, Brendy S; Bammler, Theo K; MacDonald, James W; Hull-Meichle, Rebecca L; Zraika, Sakeneh

Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice

肠道特异性脑啡肽酶缺失可保护雄性小鼠免受脂肪诱导的胰岛素分泌功能障碍

Esser, Nathalie; Mongovin, Stephen M; Barrow, Breanne M; Zraika, Sakeneh

Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice

急性抑制肠道脑啡肽酶可通过 GLP-1 受体信号传导增强雄性小鼠的胰岛素分泌

Nathalie Esser, Thomas O Mundinger, Breanne M Barrow, Sakeneh Zraika

Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice

脑啡肽酶缺乏会降低高脂喂养小鼠的肝糖异生

Nathalie Esser, Stephen M Mongovin, Thomas O Mundinger, Breanne M Barrow, Sakeneh Zraika

Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice

胰岛淀粉样多肽聚集对小鼠胰岛血管产生细胞毒性和促炎作用

Joseph J Castillo, Alfred C Aplin, Daryl J Hackney, Meghan F Hogan, Nathalie Esser, Andrew T Templin, Rehana Akter, Steven E Kahn, Daniel P Raleigh, Sakeneh Zraika, Rebecca L Hull

Does diabetes risk after SARS-CoV-2 infection depend on the viral variant?

SARS-CoV-2 感染后患糖尿病的风险是否取决于病毒变种?

Rangu, Rohita; Wander, Pandora L; Zraika, Sakeneh