日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation.

TNF-α 揭示肠道苹果酸天冬氨酸转运功能障碍,从而将帕金森病与肠道炎症联系起来。

Ghirotto Bruno, Gonçalves Luís Eduardo, Ruder Vivien, James Christina, Gerasimova Elizaveta, Rizo Tania, Wend Holger, Farrell Michaela, Gerez Juan Atilio, Prymaczok Natalia Cecilia, Kuijs Merel, Shulman Maiia, Hartebrodt Anne, Prots Iryna, Gessner Arne, Vieth Michael, Zunke Friederike, Winkler Jürgen, Blumenthal David B, Theis Fabian J, Riek Roland, Günther Claudia, Neurath Markus, Gupta Pooja, Winner Beate

Base and translation of β-glucocerebrosidase and its transporter LIMP-2 in neuropathies

神经病变中β-葡糖脑苷脂酶及其转运蛋白LIMP-2的基础和翻译

Arnold, Philipp; Zunke, Friederike

Aberrant FICD-mediated AMPylation drives α-Synuclein pathology and overall protein dyshomeostasis in dopaminergic neurons in Parkinson's disease

帕金森病中,FICD介导的异常AMP化驱动多巴胺能神经元中α-突触核蛋白病理和整体蛋白质稳态失衡。

Koller, Aron; Hoffmann, Laura; Bluhm, Alexandra; Schweigert, Alina; Schneider, Yanni; Andert, Marie; Becker, Tobias; Zunke, Friederike; Beach, Thomas G; Serrano, Geidy E; Roßner, Steffen; Winkler, Jürgen; Kielkowski, Pavel; Xiang, Wei

Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2.

β-葡糖脑苷脂酶与其转运蛋白 LIMP-2 复合物的冷冻透射电镜结构

Dobert Jan Philipp, Schäfer Jan-Hannes, Dal Maso Thomas, Ravindran Priyadarshini, Huard Dustin J E, Socher Eileen, Schildmeyer Lisa A, Lieberman Raquel L, Versées Wim, Moeller Arne, Zunke Friederike, Arnold Philipp

Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival.

受损溶酶体上的线性泛素化诱导局部 NFKB 激活并控制细胞存活

Zein Laura, Dietrich Marvin, Balta Denise, Bader Verian, Scheuer Christoph, Zellner Suzanne, Weinelt Nadine, Vandrey Julia, Mari Muriel C, Behrends Christian, Zunke Friederike, Winklhofer Konstanze F, Van Wijk Sjoerd J L

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes

α-突触核蛋白介导的细胞骨架功能障碍会损害人类少突胶质细胞的髓鞘形成

Wihan, Jeanette; Battis, Kristina; Hoffmann, Alana; Windener, Farina; Himmler, Marcus; Varghese, Anish; Koller, Aron; Karnatz, Isabell; Schubert, Dirk W; Zunke, Friederike; Xiang, Wei; Kuhlmann, Tanja; Winkler, Jürgen

Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients

利用透射电子显微镜对帕金森病患者血浆和血清中的细胞外囊泡进行表征

Weiss, Alexander; Meissner, Alex Florin; Boros, Fanni Annamária; Regensburger, Martin; Taudte, Regina Verena; Matamoros-Angles, Andreu; Arnold, Philipp; Zunke, Friederike

Two Sides of the Same Coin-Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host-Derived Extracellular Vesicles

同一枚硬币的两面——细菌和宿主来源的细胞外囊泡的机制理解、诊断应用和治疗转化

Arnold, Philipp; Boros, Fanni Annamária; Mattner, Jochen; Seidel, Gerald; Liu, Chaofan; Hensel, Inga Viktoria; Van Deun, Jan; Schwendner, Raphael; Müller-Deile, Janina; Sopel, Nina; Ramming, Andreas; Angeli, Mario R; Rauber, Simon; Vilhena, Cláudia; Baur, Andreas; Wirtz, Stefan; Überla, Klaus; Reutter, Heiko; Mulzer, Linda-Marie; Hilger, Alina C; Zunke, Friederike; Xiang, Wei; Fuhrmann, Gregor; Günther, Claudia

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients.

TNF-α 会破坏苹果酸-天冬氨酸穿梭,从而驱动帕金森病患者 iPSC 衍生的肠神经谱系发生代谢重编程

Ghirotto Bruno, Gonçalves Luís Eduardo, Ruder Vivien, James Christina, Gerasimova Elizaveta, Rizo Tania, Wend Holger, Farrell Michaela, Gerez Juan Atilio, Prymaczok Natalia Cecilia, Kuijs Merel, Shulman Maiia, Hartebrodt Anne, Prots Iryna, Gessner Arne, Zunke Friederike, Winkler Jürgen, Blumenthal David B, Theis Fabian J, Riek Roland, Günther Claudia, Neurath Markus, Gupta Pooja, Winner Beate

Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases

溶酶体组织蛋白酶在神经退行性疾病治疗中的应用潜力

Prieto Huarcaya, Susy; Zunke, Friederike