日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Combined computational and classical medicinal chemistry procedure to disclose novel pyrrole-based compounds as potential antituberculosis agents

结合计算和经典药物化学方法，发现新型吡咯类化合物作为潜在的抗结核药物。

期刊:Journal of Computer-Aided Molecular Design
影响因子:3.1
doi:10.1007/s10822-026-00794-6
Ragno, Rino; Zwergel, Clemens; Valente, Sergio; Astolfi, Roberta; Lambona, Chiara; Proia, Eleonora; Giuliani, Lidia; Franzblau, Scott G; Fioravanti, Rossella; Mai, Antonello
发表日期：2026
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Long noncoding RNA H19 promotes the acquisition of a mesenchymal-like invasive phenotype in mesothelial primary cells through an HDAC1-mediated WT1/Sp1 switch.

长链非编码 RNA H19 通过 HDAC1 介导的 WT1/Sp1 转换促进间皮原代细胞获得间充质样侵袭表型

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07956-8
Bontempi Giulio, Michetti Federica, Terri Michela, Battistelli Cecilia, Conigliaro Alice, Garbo Sabrina, Montaldo Claudia, Valente Sergio, Zwergel Clemens, Mai Antonello, Nahavandi Araghi Azadeh, Domenici Alessandro, Menè Paolo, Tripodi Marco, Strippoli Raffaele
细胞生物学
HDAC1
发表日期：2025
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A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties

一种具有新型热休克蛋白90-α抑制和衰老细胞清除特性的黄嘌呤衍生物

期刊:Aging Cell
影响因子:7.1
doi:10.1111/acel.70047
Atlante, Sandra; Cis, Luca; Pirolli, Davide; Gottardi Zamperla, Michela; Barbi, Veronica; Mai, Antonello; Zwergel, Clemens; Marcozzi, Serena; Giuliani, Maria Elisa; Bigossi, Giorgia; Lai, Giovanni; Orlando, Fiorenza; Giacconi, Robertina; Lattanzio, Fabrizia; Matacchione, Giulia; Giordani, Chiara; Bracci, Massimo; Olivieri, Fabiola; Boschi, Federico; Tabarelli De Fatis, Paola; Ivaldi, Giovanni Battista; Malavolta, Marco; Farsetti, Antonella; De Rosa, Maria Cristina; Gaetano, Carlo
细胞生物学
衰老
发表日期：2025
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Discovery of First-in-Class Carbonic Anhydrase/Histone Deacetylase Dual Inhibitors with Antiproliferative Activity in Cancer Cells

发现具有抗癌细胞增殖活性的首创碳酸酐酶/组蛋白去乙酰化酶双重抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01788
Bozdag, Murat; Mroweh, Nabil; Raucci, Alessia; Angeli, Andrea; Peppicelli, Silvia; Biagioni, Alessio; Calorini, Lido; Trisciuoglio, Daniela; Ragno, Rino; Astolfi, Roberta; Giuliani, Lidia; Zwergel, Clemens; Valente, Sergio; Andreucci, Elena; Carta, Fabrizio; Mai, Antonello; Supuran, Claudiu T
肿瘤
表观遗传
肿瘤免疫
乙酰化
细胞生物学
发表日期：2025
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Advancements in Hydrazide-Based HDAC Inhibitors: A Review of Recent Developments and Therapeutic Potential

基于酰肼的HDAC抑制剂的研究进展：近期进展及治疗潜力综述

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01677
Raucci, Alessia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
发表日期：2025
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Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties

具有碱性侧链的喹啉类DNA甲基转移酶抑制剂：设计、合成及其生化和抗癌细胞特性研究

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01029
Zwergel, Clemens; Lambona, Chiara; Fioravanti, Rossella; Raucci, Alessia; Fiorentino, Francesco; Nchugoua Tchieh, Guilaine; Jallet, Corinne; Lacroix, Laurent; Pierrettori, Michela; Pellegrini, Francesca Romana; Xiong, Yan; Jin, Jian; Arimondo, Paola; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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Cardioprotection Through Pharmacological Activation of Sirtuin 5 in a Murine Model of Acute Myocardial Infarction

在急性心肌梗死小鼠模型中，通过药物激活Sirtuin 5发挥心脏保护作用

期刊:Drug Design Development and Therapy
影响因子:5.1
doi:10.2147/DDDT.S509337
Castiello, Carola; Efentakis, Panagiotis; Nikolaou, Panagiota-Efstathia; Symeonidi, Lydia; Chania, Christina; Barla, Ioanna; Akrani, Ifigeneia; Kostomitsopoulos, Nikolaos; Gikas, Evangelos; Thomaidis, Nikolaos S; Mikros, Emmanuel; Kleinbongard, Petra; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Andreadou, Ioanna
心肌梗塞
心血管
发表日期：2025
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Procognitive Potential of Neuroprotective Triazine 5-HT(6) Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile.

在大鼠体内慢性活动中测试神经保护性三嗪 5-HT(6) 受体拮抗剂的促认知潜力：计算机辅助深入了解硫族元素差异对药理学特征的作用

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.4c00873
Jastrzębska-Więsek Magdalena, Garbo Sabrina, Cios Agnieszka, Wilczyńska-Zawal Natalia, Partyka Anna, Honkisz-Orzechowska Ewelina, Å»esławska Ewa, Handzlik Jarosław, Mordyl Barbara, Głuch-Lutwin Monika, Raucci Alessia, Hittinger Marius, Starek Małgorzata, DÄ browska Monika, Nitek Wojciech, Karcz Tadeusz, Skórkowska Alicja, Gdula-Argasińska Joanna, Czarnota-Łydka Kinga, Pyka Patryk, Szymańska Ewa, Kucwaj-Brysz Katarzyna, Zwergel Clemens, Wesołowska Anna, Battistelli Cecilia, Handzlik Jadwiga
神经科学
Rat
发表日期：2025
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Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

基于反式环丙胺的LSD1抑制剂可有效降低曼氏血吸虫的存活率

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.5c00224
Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Ganesan, A; Fioravanti, Rossella; Zwergel, Clemens; Lambona, Chiara; Valente, Sergio; Fianco, Giulia; Iuzzolino, Angela; Trisciuoglio, Daniela; Caroli, Jonatan; Mattevi, Andrea; Häberli, Cécile; Keiser, Jennifer; Rotili, Dante; Mai, Antonello
LSD1
发表日期：2025
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HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling

HDAC1/2 控制间皮/卵巢癌粘附相互作用影响 Talin-1-α5β1-整合素介导的肌动蛋白细胞骨架和细胞外基质蛋白重塑

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-023-02930-8
Michela Terri #, Pilar Sandoval #, Giulio Bontempi #, Claudia Montaldo, Henar Tomero-Sanz, Valeria de Turris, Flavia Trionfetti, Lucía Pascual-Antón, Irene Clares-Pedrero, Cecilia Battistelli, Sergio Valente, Clemens Zwergel, Antonello Mai, Laura Rosanò, Miguel Ángel Del Pozo, Miguel Sánchez-Álvarez
信号转导
肿瘤
卵巢癌
其它细胞
IHC
Donkey
IgG
发表日期：2024
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