日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Crypt density and recruited enhancers underlie intestinal tumour initiation.

隐窝密度和募集的增强子是肠道肿瘤发生的基础

Gaynor Liam, Singh Harshabad, Tie Guodong, Badarinath Krithika, Madha Shariq, Mancini Andrew, Bhattacharya Swarnabh, Hoshino Mikio, de Sauvage Frederic J, Murata Kazutaka, Jadhav Unmesh, Shivdasani Ramesh A

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

干细胞微环境特异性R-spondin 3表达的破坏会导致造血功能受损

Kurtova, Antonina V; Heinlein, Melanie; Haas, Simon; Velten, Lars; Dijkgraaf, Gerrit J P; Storm, Elaine E; Kljavin, Noelyn M; Boumahdi, Soufiane; Himmels, Patricia; Herault, Aurelie; Mancini, Andrew; Koeppen, Hartmut; Dail, Monique; Yan, Qingxiang; Zhang, Jianhuan; Koch, Ute; Radtke, Freddy; Modrusan, Zora; Metcalfe, Ciara; Piskol, Robert; de Sauvage, Frederic J

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

吉西他滨联合安慰剂或维莫德吉(一种 Hedgehog 通路抑制剂)治疗转移性胰腺癌患者的随机 Ib/II 期研究

Catenacci, Daniel V T; Junttila, Melissa R; Karrison, Theodore; Bahary, Nathan; Horiba, Margit N; Nattam, Sreenivasa R; Marsh, Robert; Wallace, James; Kozloff, Mark; Rajdev, Lakshmi; Cohen, Deirdre; Wade, James; Sleckman, Bethany; Lenz, Heinz-Josef; Stiff, Patrick; Kumar, Pankaj; Xu, Peng; Henderson, Les; Takebe, Naoko; Salgia, Ravi; Wang, Xi; Stadler, Walter M; de Sauvage, Frederic J; Kindler, Hedy L

Recurrent R-spondin fusions in colon cancer.

结肠癌中复发的R-spondin融合

Seshagiri Somasekar, Stawiski Eric W, Durinck Steffen, Modrusan Zora, Storm Elaine E, Conboy Caitlin B, Chaudhuri Subhra, Guan Yinghui, Janakiraman Vasantharajan, Jaiswal Bijay S, Guillory Joseph, Ha Connie, Dijkgraaf Gerrit J P, Stinson Jeremy, Gnad Florian, Huntley Melanie A, Degenhardt Jeremiah D, Haverty Peter M, Bourgon Richard, Wang Weiru, Koeppen Hartmut, Gentleman Robert, Starr Timothy K, Zhang Zemin, Largaespada David A, Wu Thomas D, de Sauvage Frederic J

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

小肠中储备干细胞群的存在使得Lgr5阳性细胞变得可有可无。

Tian, Hua; Biehs, Brian; Warming, Søren; Leong, Kevin G; Rangell, Linda; Klein, Ophir D; de Sauvage, Frederic J

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

经典的 Hedgehog 信号通路通过诱导基质血管周围细胞中 VEGF-A 的表达来增强肿瘤血管生成。

Chen, Weiwei; Tang, Tracy; Eastham-Anderson, Jeff; Dunlap, Debra; Alicke, Bruno; Nannini, Michelle; Gould, Stephen; Yauch, Robert; Modrusan, Zora; DuPree, Kelly J; Darbonne, Walter C; Plowman, Greg; de Sauvage, Frederic J; Callahan, Christopher A

Vive la science! Vive le hérisson!

科学万岁!赫里森万岁!

Reiter, Jeremy F; de Sauvage, Frederic J

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.

刺猬依赖性全长 Gli3 在初级纤毛中的积累及其后续降解的动力学

Wen Xiaohui, Lai Cary K, Evangelista Marie, Hongo Jo-Anne, de Sauvage Frederic J, Scales Suzie J

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

Hedgehog信号通路对于成年小鼠造血干细胞功能和造血作用并非必需。

Hofmann, Inga; Stover, Elizabeth H; Cullen, Dana E; Mao, Junhao; Morgan, Kelly J; Lee, Benjamin H; Kharas, Michael G; Miller, Peter G; Cornejo, Melanie G; Okabe, Rachel; Armstrong, Scott A; Ghilardi, Nico; Gould, Stephen; de Sauvage, Frederic J; McMahon, Andrew P; Gilliland, D Gary

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung

IL-31-IL-31R相互作用负向调节肺部2型炎症。

Perrigoue, Jacqueline G; Li, Ji; Zaph, Colby; Goldschmidt, Michael; Scott, Phillip; de Sauvage, Frederic J; Pearce, Edward J; Ghilardi, Nico; Artis, David