日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
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2026
影响因子:
–

5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

对 CRISPR-Cas9 gRNA 的 5' 端进行修饰可以改变 R 环的动力学和大小，并抑制 DNA 切割。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaa477
Mullally, Grace; van Aelst, Kara; Naqvi, Mohsin M; Diffin, Fiona M; Karvelis, Tautvydas; Gasiunas, Giedrius; Siksnys, Virginijus; Szczelkun, Mark D
发表日期：2020
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Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes.

ISP 型限制修饰酶对 DNA 序列识别的结构性见解

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkw154
Kulkarni Manasi, Nirwan Neha, van Aelst Kara, Szczelkun Mark D, Saikrishnan Kayarat
免疫/内分泌
发表日期：2016
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Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes

ISP型限制修饰酶介导的易位偶联DNA切割

期刊:Nature Chemical Biology
影响因子:13.7
doi:10.1038/nchembio.1926
Chand, Mahesh K; Nirwan, Neha; Diffin, Fiona M; van Aelst, Kara; Kulkarni, Manasi; Pernstich, Christian; Szczelkun, Mark D; Saikrishnan, Kayarat
发表日期：2015
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Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations

通过不同方向DNA位点间的长程通讯，绘制ISP型限制修饰酶对DNA的切割图谱

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkv1129
van Aelst, Kara; Saikrishnan, Kayarat; Szczelkun, Mark D
发表日期：2015
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DNA cleavage by Type ISP Restriction-Modification enzymes is initially targeted to the 3'-5' strand

ISP型限制修饰酶对DNA的切割最初靶向3'-5'链。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gks1210
van Aelst, Kara; Šišáková, Eva; Szczelkun, Mark D
发表日期：2013
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Dissociation from DNA of Type III Restriction-Modification enzymes during helicase-dependent motion and following endonuclease activity

III型限制修饰酶在解旋酶依赖性运动过程中以及内切酶活性之后从DNA上解离

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gks328
Tóth, Júlia; van Aelst, Kara; Salmons, Hannah; Szczelkun, Mark D
发表日期：2012
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Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat

III型限制性内切酶通过反向重复序列中头对头和尾对尾位点之间的长程相互作用切割DNA。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1001637107
van Aelst, Kara; Tóth, Júlia; Ramanathan, Subramanian P; Schwarz, Friedrich W; Seidel, Ralf; Szczelkun, Mark D
发表日期：2010
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