van Hoolwerff相关文献与解析，生知库 | 链接生命科学的每一步

Isolation and tracing of matrix-producing notochordal and chondrocyte cells using ACAN-2A-mScarlet reporter human iPSC lines

使用 ACAN-2A-mScarlet 报告人类 iPSC 系分离和追踪产生基质的脊索细胞和软骨细胞

Xiaole Tong, Deepani W Poramba-Liyanage, Marcella van Hoolwerff, Frank M Riemers, Joaquin Montilla-Rojo, Julie Warin, Daniela Salvatori, Anne Camus, Ingrid Meulenbelt, Yolande F M Ramos, Niels Geijsen, Marianna A Tryfonidou, Peng Shang

免疫

Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants

不平衡骨关节炎相关纤连蛋白剪接变体的鉴定和功能表征

期刊:Rheumatology

影响因子:

doi:10.1093/rheumatology/keac272

Marcella van Hoolwerff, Margo Tuerlings, Imke J L Wijnen, H Eka D Suchiman, Davy Cats, Hailiang Mei, Rob G H H Nelissen, Henrike M J van der Linden-van der Zwaag, Yolande F M Ramos, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt

A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress

利用体外3D人源软骨新生模型，探索骨关节炎风险基因对超生理机械应力的反应

期刊:Osteoarthritis and Cartilage Open

影响因子:2.8

doi:10.1016/j.ocarto.2021.100231

Timmermans, Ritchie G M; Bloks, Niek G C; Tuerlings, Margo; van Hoolwerff, Marcella; Nelissen, Rob G H H; van der Wal, Robert J P; van der Kraan, Peter M; Blom, Arjen B; van den Bosch, Martijn H J; Ramos, Yolande F M; Meulenbelt, Ingrid

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

CCAL1 基因座突变导致人类软骨下骨转换和软骨矿化的双向过程

期刊:Rheumatology

影响因子:

doi:10.1093/rheumatology/keac232

Alejandro Rodríguez Ruiz, Marcella van Hoolwerff, Sara Sprangers, Eka Suchiman, Ton Schoenmaker, Petra Dibbets-Schneider, Johan L Bloem, Rob G H H Nelissen, Christian Freund, Christine Mummery, Vincent Everts, Teun J de Vries, Yolande F M Ramos, Ingrid Meulenbelt

发表日期：2022

文献求助收藏

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

高影响的 FN1 突变会降低软骨形成潜力，并通过降低与 II 型胶原蛋白的结合来影响软骨沉积

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.abg8583

Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma, H Eka D Suchiman, Roman I Koning, Carolina R Jost, Aat A Mulder, Christian Freund, Farshid Guilak, Yolande F M Ramos, Ingrid Meulenbelt

信号转导

发表日期：2021

文献求助收藏

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets

RNA测序揭示了作用于软骨下骨和关节软骨的骨关节炎相互作用的关键决定因素：IL11和CHADL被确定为有吸引力的治疗靶点

期刊:Arthritis & Rheumatology

影响因子:10.9

doi:10.1002/art.41600

Tuerlings, Margo; van Hoolwerff, Marcella; Houtman, Evelyn; Suchiman, Eka H E D; Lakenberg, Nico; Mei, Hailiang; van der Linden, Enrike H M J; Nelissen, Rob R G H H; Ramos, Yolande Y F M; Coutinho de Almeida, Rodrigo; Meulenbelt, Ingrid

关节炎

发表日期：2021

文献求助收藏

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

人类骨软骨外植体：用于研究疾病机制和开发个性化骨关节炎治疗方法的可靠仿生模型

期刊:Rheumatology and Therapy

影响因子:2.9

doi:10.1007/s40744-021-00287-y

Evelyn Houtman, Marcella van Hoolwerff, Nico Lakenberg, Eka H D Suchiman, Enrike van der Linden-van der Zwaag, Rob G H H Nelissen, Yolande F M Ramos, Ingrid Meulenbelt

Elucidating Epigenetic Regulation by Identifying Functional cis-Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

通过鉴定骨关节炎关节软骨中功能性顺式作用长链非编码RNA及其靶标来阐明表观遗传调控

期刊:Arthritis & Rheumatology

影响因子:10.9

doi:10.1002/art.41396

van Hoolwerff, Marcella; Metselaar, Paula I; Tuerlings, Margo; Suchiman, H Eka D; Lakenberg, Nico; Ramos, Yolande F M; Cats, Davy; Nelissen, Rob G H H; Broekhuis, Demiën; Mei, Hailiang; de Almeida, Rodrigo Coutinho; Meulenbelt, Ingrid

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

RNA测序数据整合揭示了骨关节炎软骨的miRNA相互作用组

期刊:Annals of the Rheumatic Diseases

影响因子:20.6

doi:10.1136/annrheumdis-2018-213882

Coutinho de Almeida, Rodrigo; Ramos, Yolande F M; Mahfouz, Ahmed; den Hollander, Wouter; Lakenberg, Nico; Houtman, Evelyn; van Hoolwerff, Marcella; Suchiman, H Eka D; Rodríguez Ruiz, Alejandro; Slagboom, P Eline; Mei, Hailiang; Kiełbasa, Szymon M; Nelissen, Rob G H H; Reinders, Marcel; Meulenbelt, Ingrid

The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells

生长激素（GH）对免疫衰老的影响：探索B细胞和T细胞的作用

Isolation and tracing of matrix-producing notochordal and chondrocyte cells using ACAN-2A-mScarlet reporter human iPSC lines

使用 ACAN-2A-mScarlet 报告人类 iPSC 系分离和追踪产生基质的脊索细胞和软骨细胞

Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants

不平衡骨关节炎相关纤连蛋白剪接变体的鉴定和功能表征

A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress

利用体外3D人源软骨新生模型，探索骨关节炎风险基因对超生理机械应力的反应

Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

CCAL1 基因座突变导致人类软骨下骨转换和软骨矿化的双向过程

High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

高影响的 FN1 突变会降低软骨形成潜力，并通过降低与 II 型胶原蛋白的结合来影响软骨沉积

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets

RNA测序揭示了作用于软骨下骨和关节软骨的骨关节炎相互作用的关键决定因素：IL11和CHADL被确定为有吸引力的治疗靶点

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis

人类骨软骨外植体：用于研究疾病机制和开发个性化骨关节炎治疗方法的可靠仿生模型

Elucidating Epigenetic Regulation by Identifying Functional cis-Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

通过鉴定骨关节炎关节软骨中功能性顺式作用长链非编码RNA及其靶标来阐明表观遗传调控

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

RNA测序数据整合揭示了骨关节炎软骨的miRNA相互作用组