Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA
通过P450氧化还原伴侣优化和DoxA结构分析对阿霉素生物合成进行代谢工程改造
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69194-6
Koroleva, Arina; Artukka, Erika; Yamada, Keith; Newmister, Sean A; Harte, Ralph J; Boesger, Hannah; Londen, Mikael; Sanders, Jacob N; Tirkkonen, Heli; Kannisto, Matti; Kuin, Rosan C M; Hulst, Mandy; Wang, Rongbin; Leskinen, Ester; Barillec, Morgane; Niemi, Jarmo; van Wezel, Gilles P; Neefjes, Jacques; Nybo, S Eric; Houk, Kendall N; Sherman, David H; Kim, Robbert Q; Metsä-Ketelä, Mikko