Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1
Kit受体酪氨酸激酶的致癌突变会改变底物特异性,并诱导蛋白酪氨酸磷酸酶SHP-1的降解。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.93.25.14665
Piao, X; Paulson, R; van der Geer, P; Pawson, T; Bernstein, A