日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

通过改造共信号受体来生成脱靶交叉反应性降低的T细胞

Cabezas-Caballero, Jose; Huhn, Anna; Kutuzov, Mikhail A; Andre, Violaine; Shomuradova, Alina; Peeters, Bas W A; Gillespie, Geraldine M; van der Merwe, P Anton; Dushek, Omer

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens.

小鼠 T 细胞受体 OT-I 对外来抗原和自身抗原的区分能力不完美。

Huhn Anna, Kutuzov Mikhail A, Maclean Keir, Uhl Lion F K, Mahale Jagdish M, Gérard Audrey, van der Merwe P Anton, Dushek Omer

Platforms for studying cell-cell recognition by immune cells

用于研究免疫细胞细胞间识别的平台

Kramer, Jordan; van der Merwe, P Anton; Dushek, Omer

Biomarkers of response to PD-1 pathway blockade

PD-1通路阻断反应的生物标志物

Li, Hanxiao; van der Merwe, P Anton; Sivakumar, Shivan

MHC binding affects the dynamics of different T-cell receptors in different ways

MHC结合以不同的方式影响不同T细胞受体的动态变化。

Knapp, Bernhard; van der Merwe, P Anton; Dushek, Omer; Deane, Charlotte M

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

多位点磷酸化调节T细胞受体ζ链的效力,但不调节开关样反应。

Mukhopadhyay, Himadri; de Wet, Ben; Clemens, Lara; Maini, Philip K; Allard, Jun; van der Merwe, P Anton; Dushek, Omer

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.

SpyAvidin 中心可实现精确且超稳定的正交纳米组装

Fairhead Michael, Veggiani Gianluca, Lever Melissa, Yan Jun, Mesner Dejan, Robinson Carol V, Dushek Omer, van der Merwe P Anton, Howarth Mark

An induced rebinding model of antigen discrimination

抗原识别的诱导重结合模型

Dushek, Omer; van der Merwe, P Anton

Mutant prolactin receptor and familial hyperprolactinemia

突变催乳素受体和家族性高催乳素血症

Newey, Paul J; Gorvin, Caroline M; Cleland, Stephen J; Willberg, Christian B; Bridge, Marcus; Azharuddin, Mohammed; Drummond, Russell S; van der Merwe, P Anton; Klenerman, Paul; Bountra, Chas; Thakker, Rajesh V

The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor

CD45 和 CD148 的大型胞外结构域调节它们与配体结合的 T 细胞受体的分离和抑制。

Cordoba, Shaun-Paul; Choudhuri, Kaushik; Zhang, Hao; Bridge, Marcus; Basat, Alp Bugra; Dustin, Michael L; van der Merwe, P Anton