骨质疏松相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial

罗莫索珠单抗治疗绝经后骨质疏松症3个月与12个月的疗效比较（LIDA）：一项开放标签、非劣效性、随机对照试验

期刊:Lancet Diabetes & Endocrinology

影响因子:41.8

doi:10.1016/S2213-8587(25)00319-5

Leder, Benjamin Z; Ramchand, Sabashini K; Jordan, Mackenzie; Ryan, Savannah; Patnaik, Aparna; Lee, Hang; Tsai, Joy N

发表日期：2026

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A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration.

一种基于拟贻贝足蛋白的水凝胶粘合剂，具有骨血管免疫耦合效应，可用于骨质疏松骨-植入物整合。

期刊:Advanced Materials

影响因子:26.8

doi:10.1002/adma.202511840

免疫/内分泌

发表日期：2026

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Corrigendum to "Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures" [Bioactive materials 54 (2025) 631-647]

对“通过双载药预混镁三磷酸镁骨水泥调节骨稳态治疗骨质疏松性椎体压缩性骨折”的更正[生物活性材料54（2025）631-647]

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2025.10.005

Liu, Jiawei; Zhu, Jinjin; Goto, Takashi; Yang, Shuhui; Kang, Honglei; Wang, Xiumei; Dai, Honglian

发表日期：2026

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Spatiotemporally adaptive metal-gas nanotherapy: Acid-triggered cascade release for osteoporosis treatment

时空自适应金属-气体纳米疗法：酸触发级联释放治疗骨质疏松症

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2026.04.018

Xiong, Wei; Hu, Yiming; Cai, Changxiong; Fang, Xingyun; Liu, Ye; Tian, Xiangyu; Ye, Qingsong; Cheng, Xigao; Ye, Jing

发表日期：2026

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Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis

为绝经后骨质疏松症设计了一种靶向骨骼的ROS响应纳米平台，用于精准抑制糖酵解。

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2025.11.032

Wu, Qihang; Miao, Jiansen; Chen, Yu; Yang, Yayun; Liang, Haibo; Yu, Chenxin; Wang, Chenyu; Tu, Yiting; Wu, Yinuo; Xu, Yining; Yang, Xiao; Kwan, Kenny Yat Hong; Shi, Changcan; Wang, Xiangyang; Xu, Jiake; Jin, Haiming

发表日期：2026

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Lymphatic incorporated biomimetic scaffold enhances Osteoangio-lymphogenic coupling via HIF-1α mediated mitochondrial reprogramming for osteoporotic bone repair

淋巴管整合的仿生支架通过HIF-1α介导的线粒体重编程增强骨血管-淋巴生成耦合，从而促进骨质疏松症的修复。

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2025.10.041

Sun, Weipeng; Lin, Qing; Zhao, Biyi; Li, Minying; Xiao, Jiacong; Jin, Xueshan; Liu, Jinfu; Wang, Yifei; Zhang, Ronghua; Li, Xiaoyun; Jiang, Ziwei

发表日期：2026

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Age-related GSS promoter methylation in BMSCs drives osteoporosis and the reversal by targeted GSH delivery

骨髓间充质干细胞中与年龄相关的GSS启动子甲基化驱动骨质疏松症，而靶向递送GSH可逆转骨质疏松症。

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2025.12.048

Li, Pan; Liang, Zhuowen; Zeng, Xianyan; Lei, Runbo; Guo, Shuo; Zhang, Zhao; Zhang, Guangwei; Li, Jianxiong; Qin, Anhui; Qu, Mi; Su, Kangkang; Yu, Dechen; Liu, Wenwen; Luo, Zhuojing

发育与干细胞

细胞生物学

发表日期：2026

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Targeting the osteoporotic bone microenvironment: Mechanistic insight and therapeutic biomaterials for accelerating bone regeneration

靶向骨质疏松骨微环境：加速骨再生的机制研究和治疗性生物材料

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2026.02.024

Lu, Xinya; Zhang, Anbiao; Zhang, Chengyun; Guo, Dong; Li, Zhong Alan; Xie, Denghui

发表日期：2026

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Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis.

对醌类化合物库的筛选发现癸基泛醌是一种抗氧化剂和抗凋亡剂，可通过 CD39/CD73/腺苷轴对抗糖皮质激素诱导的骨质疏松症。

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2026.03.062

Xu Yu, Xu Wenpeng, Zhang Wencan, Li Shangzhi, Zhang Dingxin, Lin Xiangyu, Sun Qian, Wang Yanguo, Hu Peijie, Si Haipeng

发表日期：2026

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Hierarchical micro-/nanostructured hydroxyapatite scaffolds promote osteoporotic bone regeneration via activation of hedgehog and HIF-1Î± signaling.

分级微/纳米结构羟基磷灰石支架通过激活 hedgehog 和 HIF-1α 信号通路促进骨质疏松骨再生。

期刊:Bioactive Materials

影响因子:20.3

doi:10.1016/j.bioactmat.2026.01.049

发表日期：2026

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