日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Nav1.7 作为软骨细胞调节剂和骨关节炎的治疗靶点

Wenyu Fu, Dmytro Vasylyev, Yufei Bi, Mingshuang Zhang, Guodong Sun, Asya Khleborodova, Guiwu Huang, Libo Zhao, Renpeng Zhou, Yonggang Li, Shujun Liu, Xianyi Cai, Wenjun He, Min Cui, Xiangli Zhao, Aubryanna Hettinghouse, Julia Good, Ellen Kim, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Edward X G

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer

癌症相关成纤维细胞表型与非小细胞肺癌患者的预后相关

Lena Cords ,Stefanie Engler ,Martina Haberecker ,Jan Hendrik Rüschoff ,Holger Moch ,Natalie de Souza ,Bernd Bodenmiller

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

表观遗传读取器 ZMYND11 的非规范功能限制了 HNRNPA1 介导的应激颗粒形成和致癌活性

Cheng Lian #, Chunyi Zhang #, Pan Tian, Qilong Tan, Yu Wei, Zixian Wang, Qin Zhang, Qixiang Zhang, Mengjie Zhong, Li-Quan Zhou, Xisong Ke, Huabing Zhang, Yao Zhu, Zhenfei Li, Jingdong Cheng, Gong-Hong Wei

Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion

大规模评估 RNA 结合蛋白激活外显子纳入的能力

Jonathan C Schmok, Manya Jain, Lena A Street, Alex T Tankka, Danielle Schafer, Hsuan-Lin Her, Sara Elmsaouri, Maya L Gosztyla, Evan A Boyle, Pratibha Jagannatha, En-Ching Luo, Ester J Kwon, Marko Jovanovic, Gene W Yeo

A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice

脑桥中脑 PACAPergic 通路是小鼠恐慌样行为和躯体症状的基础

Sukjae J Kang #, Jong-Hyun Kim #, Dong-Il Kim, Benjamin Z Roberts, Sung Han

EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells

EXO1 和 DNA2 介导的 ssDNA 间隙扩展对于 ATR 激活和维持 BRCA1 缺陷细胞的活力至关重要

Néstor García-Rodríguez, Iria Domínguez-García, María Del Carmen Domínguez-Pérez, Pablo Huertas

Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts

DNA双链断裂的切除激活了Mre11-Rad50-Nbs1-和Rad9-Hus1-Rad1依赖性机制,这些机制冗余地促进了非洲爪蟾卵提取物中ATR检查点的激活和末端加工。

Kensuke Tatsukawa ,Reihi Sakamoto ,Yoshitaka Kawasoe ,Yumiko Kubota ,Toshiki Tsurimoto ,Tatsuro S Takahashi ,Eiji Ohashi

USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress

在复制压力下,USP1 依赖的 PRIMPOL 产生的新生 DNA 链不连续性的核溶解扩增

Alexandra Nusawardhana, Lindsey M Pale, Claudia M Nicolae, George-Lucian Moldovan

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

通过跨谱系免疫库挖掘快速优化抗TREM2临床先导抗体的亲和力

Yi-Chun Hsiao ,Heidi Ackerly Wallweber ,Robert G Alberstein ,Zhonghua Lin ,Changchun Du ,Ainhoa Etxeberria ,Theint Aung ,Yonglei Shang ,Dhaya Seshasayee ,Franziska Seeger ,Andrew M Watkins ,David V Hansen ,Christopher J Bohlen ,Peter L Hsu ,Isidro Hötzel

Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM

冷冻电镜揭示Polθ解旋酶小分子抑制剂的结构基础

Fumiaki Ito # ,Ziyuan Li # ,Leonid Minakhin ,Gurushankar Chandramouly ,Mrityunjay Tyagi ,Robert Betsch ,John J Krais ,Bernadette Taberi ,Umeshkumar Vekariya ,Marissa Calbert ,Tomasz Skorski ,Neil Johnson ,Xiaojiang S Chen ,Richard T Pomerantz