p38 MAPK相关文献与解析，生知库 | 链接生命科学的每一步

Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia

双靶向混合纳米囊泡通过调节DUSP4/p38 MAPK通路协调骨骼肌肉再生，从而逆转骨质疏松症。

Che, Benchi; Cui, Yongzhi; Chen, Zhengsheng; Gao, Yanchun; Luo, Lei; Zheng, Kaiwen; Liu, Jiashuo; Xiang, Yu; Cheng, Jiaqi; Guo, Yuanyuan; Li, Qing; Fu, Dehao

p38 MAPK

UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte.

UBQLN1 抑制通过下调肝细胞中的 SIKE/p38 MAPK 通路来减少 MASH 的进展。

期刊:Journal of Nanobiotechnology

影响因子:12.6

doi:10.1186/s12951-026-04202-x

Chen Yifei, Yang Fuji, Zheng Guojun, Wang Yanjin, Liu Likang, Yan Yongmin

Blastocystis sp. induces neurocognitive deficits in mice via p38 MAPK-mediated downregulation of NR4A1

Blastocystis sp. 通过 p38 MAPK 介导的 NR4A1 下调诱导小鼠神经认知缺陷

期刊:Gut Microbes

影响因子:11

doi:10.1080/19490976.2026.2659393

Yang, Xin; Nan, Huizhu; Zhao, Yan; Li, Huan; Zhang, Xiangyun; He, Mu; Ma, Lei

Role of p38 MAPK in the cytokine reprogramming of a human leukemic cell line with a drug-resistant phenotype

p38 MAPK在具有耐药表型的人类白血病细胞系的细胞因子重编程中的作用

期刊:Cell Communication and Signaling

影响因子:8.9

doi:10.1186/s12964-026-02653-1

Cadenas-Garrido, Paula; García-Serna, Azahara M; Parrado, Antonio; Martínez-García, Javier; Herrera-Suarez, Marcela; Cánovas, Manuel; de Diego Puente, Teresa; Saceda, Miguel; Pelegrin, Pablo; Díaz-Carrasco, María Sacramento; Martín-Orozco, Elena

Magnetic chitosan nanoparticle-exosome hydrogel enhances bladder function in diabetic bladder dysfunction via activating the FAK-p38 MAPK-GATA4 axis in adipose-derived mesenchymal stromal cells

磁性壳聚糖纳米颗粒-外泌体水凝胶通过激活脂肪间充质干细胞中的FAK-p38 MAPK-GATA4通路，增强糖尿病膀胱功能障碍患者的膀胱功能。

期刊:Regenerative Biomaterials

影响因子:8.1

doi:10.1093/rb/rbag007

Zheng, Junhao; Zhang, Daofeng; Li, Haorui; Jin, Rongyang; Chen, Hao; Sun, Xiaoliang; Zhang, Haiyang

2'-Fucosyllactose and its metabolites propionate/butyrate suppress inflammation through a shared TLR4/p38 MAPK-dependent pathway in vitro and in vivo.

2'-岩藻糖基乳糖及其代谢产物丙酸/丁酸通过共同的 TLR4/p38 MAPK 依赖性通路在体外和体内抑制炎症。

期刊:Current Research in Food Science

影响因子:7

doi:10.1016/j.crfs.2026.101352

Na Kai, Chao Cheng, Yu Tianfei, Wang Liqun, Liu Xiaotong, Zhang Li, Feng Kejue, Lei Junhua, Xiong Yu, Guo Xiaohua

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis.

TRPC6 通过 BMPR2-p38 MAPK 信号轴控制棕色脂肪组织产热。

期刊:Molecular Metabolism

影响因子:6.6

doi:10.1016/j.molmet.2026.102341

Xie Danyingzhu, Peng Ying, Zhang Susu, Mai Xudong, Wen Weiheng, Wang Ming, Wang Qiao-Ping, Sun Jia

Targeting p38 MAPK signaling pathway:Â Quercetin as a novel therapy for TMJ synovitis.

靶向 p38 MAPK 信号通路：槲皮素作为治疗颞下颌关节滑膜炎的新疗法。

期刊:International Journal of Molecular Medicine

影响因子:5.8

doi:10.3892/ijmm.2025.5692

Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits

反复轻度创伤性脑损伤后抑制p38 MAPK可改善免疫信号传导和功能缺陷

期刊:Acta Neuropathologica Communications

影响因子:5.7

doi:10.1186/s40478-026-02226-w

Li, Chenxing; Griffin, Martin N; Triplett, Sydney E; Silverio, Anna E; Pettit, Elizabeth; Rohrer, Alivia M; Callaway, Jacob P; Munagapati, Pranavvarma V; Saah, Paul F Jr; Sanz, Paul I; Rivera Moctezuma, Felix G; Holberton, Abigail; Gomez, Angela; Buckley, Erin M; Wood, Levi B

p38 MAPK orchestrates cross-tissue potassium homeostasis for survival

p38 MAPK 协调跨组织钾稳态以维持生存

Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia

双靶向混合纳米囊泡通过调节DUSP4/p38 MAPK通路协调骨骼肌肉再生，从而逆转骨质疏松症。

UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte.

UBQLN1 抑制通过下调肝细胞中的 SIKE/p38 MAPK 通路来减少 MASH 的进展。

Blastocystis sp. induces neurocognitive deficits in mice via p38 MAPK-mediated downregulation of NR4A1

Blastocystis sp. 通过 p38 MAPK 介导的 NR4A1 下调诱导小鼠神经认知缺陷

Role of p38 MAPK in the cytokine reprogramming of a human leukemic cell line with a drug-resistant phenotype

p38 MAPK在具有耐药表型的人类白血病细胞系的细胞因子重编程中的作用

Magnetic chitosan nanoparticle-exosome hydrogel enhances bladder function in diabetic bladder dysfunction via activating the FAK-p38 MAPK-GATA4 axis in adipose-derived mesenchymal stromal cells

磁性壳聚糖纳米颗粒-外泌体水凝胶通过激活脂肪间充质干细胞中的FAK-p38 MAPK-GATA4通路，增强糖尿病膀胱功能障碍患者的膀胱功能。

2'-Fucosyllactose and its metabolites propionate/butyrate suppress inflammation through a shared TLR4/p38 MAPK-dependent pathway in vitro and in vivo.

2'-岩藻糖基乳糖及其代谢产物丙酸/丁酸通过共同的 TLR4/p38 MAPK 依赖性通路在体外和体内抑制炎症。

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis.

TRPC6 通过 BMPR2-p38 MAPK 信号轴控制棕色脂肪组织产热。

Targeting p38 MAPK signaling pathway:Â Quercetin as a novel therapy for TMJ synovitis.

靶向 p38 MAPK 信号通路：槲皮素作为治疗颞下颌关节滑膜炎的新疗法。

Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits

反复轻度创伤性脑损伤后抑制p38 MAPK可改善免疫信号传导和功能缺陷