日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6.

DCLK1 通过去泛素化 HDAC6 来驱动膀胱癌的恶性进展和化疗耐药性。

Du Ashuai, Zhou Yuzheng, Deng Xinpei, Yuan Dongbo, Li Kai, Luo Yuanyuan, Tan Songsong, Dai Xuchao, Yu Bo, Jiang Kehua, Tan Xingliang, Zhu Jianguo

Matrix stiffness induces Ca(2+)-DCLK1-PIP5K1A mechanotransduction as a context-specific amplifier in pancreatic cancer progression and chemotherapy resistance

基质刚度诱导Ca(2+)-DCLK1-PIP5K1A机械转导,在胰腺癌进展和化疗耐药中发挥特异性放大作用。

Zhang, Haoxiang; Zhao, Chuanbing; Chen, Jiaoshun; Hu, Xiaoqing; Bai, Jianwei; He, Long; Deng, Zanglong; Yin, Tao

Genome-wide CRISPR-Cas9 screening identifies CLK1 inhibition as a strategy to restore PARP inhibitor sensitivity via ERCC1 isoform switching

全基因组 CRISPR-Cas9 筛选发现,抑制 CLK1 可通过 ERCC1 亚型转换恢复 PARP 抑制剂敏感性。

Liu, Chaohua; Xu, Fei; Wu, Yutuan; Li, Jiana; Ni, Mengdong; Xia, Siyu; Chen, Lihua; Zhao, Haiyun; Yu, Min; Zhou, Yuqi; Zhang, Meiqin; Li, Jiajia; Wu, Xiaohua; Huang, Yan; Zhu, Tao; Chen, Xiaojun

CLK1 is a potential tumor suppressor for NSCLC by regulating cell proliferation and immune infiltration

CLK1通过调节细胞增殖和免疫浸润,可能成为非小细胞肺癌的肿瘤抑制因子。

Ma, Rui; Zhang, Xiaoyan; Wang, Yunlong; Ma, Jia

Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4

儿童中枢神经系统肿瘤中的选择性剪接凸显了癌胚候选基因 CLK1 外显子 4

Naqvi, Ammar S; Sullivan, Patricia J; Corbett, Ryan J; Sehgal, Priyanka; Conkrite, Karina L; Rathi, Komal S; Ennis, Brian M; Hayer, Katharina E; Zhang, Bo; Brown, Miguel A; Miller, Daniel P; Sickler, Alex; Kraya, Adam A; Coleman, Kaleem L; Dybas, Joseph M; Geng, Zhuangzhuang; Blackden, Christopher; Arif, Shehbeel; Chroni, Antonia; Lahiri, Aditya; Hollawell, Madison L; Storm, Phillip B; Haydar, Dalia; Foster, Jessica B; Koptyra, Mateusz; Madsen, Peter J; Diskin, Sharon J; Thomas-Tikhonenko, Andrei; Resnick, Adam C; Rokita, Jo Lynne

Hypoxic stimulation of DCLK1 transcription and alternative-promoter switching fuels tumor malignancy in clear cell renal cell carcinoma

缺氧刺激DCLK1转录和启动子替代转换促进透明细胞肾细胞癌的肿瘤恶性进展

Yao, Jiannan; Huang, Xuying; Sun, Qianqian; Zhao, Wenjing; Weygant, Nathaniel; Fan, Xiaona; Liu, Heshu; Xiao, Zeru; Yan, Rui; Ge, Yang; An, Guangyu; Liu, Jian

Regulation of CLK1 Isoform Expression by Alternative Splicing in Activated Human Monocytes Contributes to Activation-Associated TNF Production

活化的人类单核细胞中通过选择性剪接调控CLK1亚型表达,从而促进活化相关的TNF产生。

van Haaren, Maurice J H; Bodelón, Alejandra; Sijbers, Lyanne J P M; Scholman, Rianne; Picavet, Lucas W; Calis, Jorg J A; Vastert, Sebastiaan J; van Loosdregt, Jorg

Balancing Regeneration and Resistance: Targeting DCLK1 to Mitigate Gastrointestinal Radiation Injury and Oncogenesis

平衡再生与抵抗:靶向DCLK1以减轻胃肠道放射损伤和肿瘤发生

Moore, Landon L; Jaboin, Jerry; Brown, Milton L; Houchen, Courtney W

Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective

稳定的氢键网络对于选择性抑制CLK1至关重要:计算视角

Huang, Yuzhou; Hu, Baichun; Liu, Haihan; Wang, Jian; Duan, Na

Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1

结构导向筛选鉴定出生物活性植物成分 Hernandonine 和 Anolobin,它们是双特异性蛋白激酶 CLK1 的潜在抑制剂。

Khan, Sumaiya; Choudhury, Arunabh; Mohammad, Taj; Shamsi, Anas; Hassan, Md Imtaiyaz; Islam, Asimul