AF9相关文献与解析，生知库 | 链接生命科学的每一步

Barta, Paige A; Garnar-Wortzel, Leopold; Bishop, Timothy R; Hayward, Rachel E; Hargis, Lauren M; Shaum, James B; Kwok, Hui Si; Liau, Brian B; Cravatt, Benjamin F; Erb, Michael A

ENL

AF9

PAF1

发表日期：2026

文献求助收藏

H2-K1 protects murine MLL-AF9 leukemia stem cells from natural killer cell-mediated immune surveillance

H2-K1保护小鼠MLL-AF9白血病干细胞免受自然杀伤细胞介导的免疫监视

期刊:Haematologica

影响因子:7.9

doi:10.3324/haematol.2024.286468

Ghosh, Somadri; Rodriguez-Zabala, Maria; Dushime, Gladys Telliam; Reinbach, Katrin; Ramakrishnan, Ramprasad; Sitnicka, Ewa; Järås, Marcus

Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4

喹啉类抑制剂对转录共激活因子AF9/ENL和DOT1L/AF4之间蛋白质-蛋白质相互作用的合成、构效关系及抗肿瘤活性研究

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c01587

Mishra, Chandra Bhushan; Li, Xin; Moku, Bala Krishna; Kwak, Sehun; Garad, Dnyaneshwar N; Song, Yongcheng

Chinese sacbrood virus mediates m6A modification to target and suppress the expression of hemolymph maintenance gene AF9, exacerbating bee infections

中国囊状幼虫病病毒通过介导m6A修饰来靶向并抑制血淋巴维持基因AF9的表达，从而加剧蜜蜂感染。

期刊:Journal of Virology

影响因子:4

doi:10.1128/jvi.02117-24.

Hua Bai #,Yueyu Ma #,Huitong Qiu,Yang Qi,Yingshuo Huang,Yaxi Guo, Li Sun,Ming Li,Dongliang Fei,Mingxiao Ma,Yuming Liu

Molecular insights into chemotherapy resistance mediated by MLL-AF9 fusion gene in pediatric B-cell acute lymphoblastic leukemia

儿童B细胞急性淋巴细胞白血病中MLL-AF9融合基因介导的化疗耐药性的分子机制研究

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2025.110321

Xu Sang ，Yanchun Guan ，Mengying Jiang ，Xin Chen ，Zhen Zhang ，Wansheng Peng ，Yumeng Wu

Discovery of Pre-Clinical Candidate VU6008055/AF98943: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy.

临床前候选药物 VU6008055/AF98943 的发现：一种具有高度选择性、口服生物利用度高、结构独特的 M(4) 毒蕈碱乙酰胆碱受体正变构调节剂 (PAM)，具有强大的体内疗效。

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.5c00277

Twist family BHLH transcription factor 1 is required for the maintenance of leukemia stem cell in MLL-AF9(+) acute myeloid leukemia

Twist家族BHLH转录因子1是MLL-AF9(+)急性髓系白血病中白血病干细胞维持所必需的。

期刊:Haematologica

影响因子:7.9

doi:10.3324/haematol.2023.282748

Wang, Nan; Yin, Jing; You, Na; Zhu, Wenqi; Guo, Nini; Liu, Xiaoyan; Zhang, Peiwen; Huang, Wanling; Xie, Yueqiao; Ren, Qian; Ma, Xiaotong

Evaluation of acyllysine isostere interactions with the aromatic pocket of the AF9 YEATS domain

评估酰基赖氨酸等排体与AF9 YEATS结构域芳香口袋的相互作用

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.4533

Travis, Christopher R; Francis, Denver Y; Williams, David C Jr; Waters, Marcey L

AF9

发表日期：2023

文献求助收藏

Magnetoelectric nanoparticles drive TAF9B(+) T(H)2 cell expansion to alleviate inflammation.

磁电纳米粒子驱动 TAF9B(+) T(H)2 细胞扩增以减轻炎症。

Mechanism of AF9 (MLLT3)-Partner Dissociation in Mixed-Lineage Leukemia-Rearranged Leukemia

混合谱系白血病重排白血病中AF9（MLLT3）-伴侣解离的机制

A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition

PAF1与ENL/AF9 YEATS抑制之间的化学遗传相互作用

H2-K1 protects murine MLL-AF9 leukemia stem cells from natural killer cell-mediated immune surveillance

H2-K1保护小鼠MLL-AF9白血病干细胞免受自然杀伤细胞介导的免疫监视

Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4

喹啉类抑制剂对转录共激活因子AF9/ENL和DOT1L/AF4之间蛋白质-蛋白质相互作用的合成、构效关系及抗肿瘤活性研究

Chinese sacbrood virus mediates m6A modification to target and suppress the expression of hemolymph maintenance gene AF9, exacerbating bee infections

中国囊状幼虫病病毒通过介导m6A修饰来靶向并抑制血淋巴维持基因AF9的表达，从而加剧蜜蜂感染。

Molecular insights into chemotherapy resistance mediated by MLL-AF9 fusion gene in pediatric B-cell acute lymphoblastic leukemia

儿童B细胞急性淋巴细胞白血病中MLL-AF9融合基因介导的化疗耐药性的分子机制研究

Discovery of Pre-Clinical Candidate VU6008055/AF98943: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy.

临床前候选药物 VU6008055/AF98943 的发现：一种具有高度选择性、口服生物利用度高、结构独特的 M(4) 毒蕈碱乙酰胆碱受体正变构调节剂 (PAM)，具有强大的体内疗效。

Twist family BHLH transcription factor 1 is required for the maintenance of leukemia stem cell in MLL-AF9(+) acute myeloid leukemia

Twist家族BHLH转录因子1是MLL-AF9(+)急性髓系白血病中白血病干细胞维持所必需的。

Evaluation of acyllysine isostere interactions with the aromatic pocket of the AF9 YEATS domain

评估酰基赖氨酸等排体与AF9 YEATS结构域芳香口袋的相互作用