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Targeting CPSF73, the mRNA 3' End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal State

靶向 CPSF73（mRNA 3' 末端加工内切酶）可使癌细胞远离间质状态

期刊:

影响因子:

doi:10.64898/2026.03.01.708894

Naseri, Marzieh; Liu, Huiyun; Wang, Luyang; Mostafa, Salwa Mohd; Pirmardan, Ehsan Ranaei; Tian, Bin; Moore, Claire L

An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11

对人类核酸内切酶CPSF73和INTS11活性位点中金属离子含量的检测

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2023.103047

Huang, Ji; Liu, Xiangyang; Sun, Yadong; Li, Zhuang; Lin, Min-Han; Hamilton, Keith; Mandel, Corey R; Sandmeir, Felix; Conti, Elena; Oyala, Paul H; Tong, Liang

CPSF7

发表日期：2023

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Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

HIV-1 进入细胞核后，形成核 CPSF6/CPSF5 生物分子凝聚物对于有效感染至关重要

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-023-37364-x

Charlotte Luchsinger, KyeongEun Lee, Gonzalo A Mardones, Vineet N KewalRamani, Felipe Diaz-Griffero

Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin

CPSF73-CPSF100 C端异二聚体的分子细节及其与Symplekin的相互作用

期刊:Open Biology

影响因子:3.6

doi:10.1098/rsob.230221

Thore, Stéphane; Raoelijaona, Finaritra; Talenton, Vincent; Fribourg, Sébastien; Mackereth, Cameron D

Silencing of CPSF7 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells by blocking the AKT/mTOR signaling pathway

CPSF7 的沉默通过阻断 AKT/mTOR 信号通路抑制肺腺癌细胞的增殖、迁移和侵袭。

期刊:Open Medicine

影响因子:1.6

doi:10.1515/med-2022-0570

An, Weishao; Yu, Fang

FttA is a CPSF73 homologue that terminates transcription in Archaea

FttA是CPSF73的同源物，在古细菌中终止转录。

期刊:Nature Microbiology

影响因子:20.5

doi:10.1038/s41564-020-0667-3

Travis J Sanders ，Breanna R Wenck ，Jocelyn N Selan ，Mathew P Barker ，Stavros A Trimmer ，Julie E Walker ，Thomas J Santangelo

Association of Common Genetic Variants in the CPSF7 and SDHAF2 Genes with Canine Idiopathic Pulmonary Fibrosis in the West Highland White Terrier

西高地白梗犬CPSF7和SDHAF2基因常见遗传变异与犬特发性肺纤维化的关联

期刊:Genes

影响因子:2.8

doi:10.3390/genes11060609

Piras, Ignazio S; Bleul, Christiane; Siniard, Ashley; Wolfe, Amanda J; De Both, Matthew D; Hernandez, Alvaro G; Huentelman, Matthew J

snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis

拟南芥发育过程中，含CPSF73的复合物对snRNA 3'末端进行加工至关重要

期刊:PLoS Biology

影响因子:7.2

doi:10.1371/journal.pbio.1002571

Liu, Yunfeng; Li, Shengjun; Chen, Yuan; Kimberlin, Athen N; Cahoon, Edgar B; Yu, Bin

Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription

单纯疱疹病毒 ICP4 与 PolII 转录中多个步骤中起作用的细胞复合物的时间关联

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0078242

Lauren M Wagner, Neal A DeLuca

An N-terminal helix of Lsm11 stabilizes CPSF73 in U7 snRNP for histone pre-mRNA 3'-end processing

Lsm11 的 N 端螺旋可稳定 U7 snRNP 中的 CPSF73，从而促进组蛋白前体 mRNA 3' 端加工。

Targeting CPSF73, the mRNA 3' End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal State

靶向 CPSF73（mRNA 3' 末端加工内切酶）可使癌细胞远离间质状态

An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11

对人类核酸内切酶CPSF73和INTS11活性位点中金属离子含量的检测

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

HIV-1 进入细胞核后，形成核 CPSF6/CPSF5 生物分子凝聚物对于有效感染至关重要

Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin

CPSF73-CPSF100 C端异二聚体的分子细节及其与Symplekin的相互作用

Silencing of CPSF7 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells by blocking the AKT/mTOR signaling pathway

CPSF7 的沉默通过阻断 AKT/mTOR 信号通路抑制肺腺癌细胞的增殖、迁移和侵袭。

FttA is a CPSF73 homologue that terminates transcription in Archaea

FttA是CPSF73的同源物，在古细菌中终止转录。

Association of Common Genetic Variants in the CPSF7 and SDHAF2 Genes with Canine Idiopathic Pulmonary Fibrosis in the West Highland White Terrier

西高地白梗犬CPSF7和SDHAF2基因常见遗传变异与犬特发性肺纤维化的关联

snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis

拟南芥发育过程中，含CPSF73的复合物对snRNA 3'末端进行加工至关重要

Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription

单纯疱疹病毒 ICP4 与 PolII 转录中多个步骤中起作用的细胞复合物的时间关联