日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies

利福霉素 O 作为一种新型 CRBN 配体,用于靶向降解造血系统恶性肿瘤中的 IKZF1/3 蛋白

Liao, Liang; Wang, Qiang; Gao, Zhengyang; Liu, Jiayao; Tong, Yuxuan; Chen, Xin; Zhu, Jin; Li, Jian; Wei, Jinlian

Cereblon (CRBN) inhibits prostate cancer metastasis by negatively regulating 6-phosphogluconate dehydrogenase (6PGD).

Cereblon (CRBN) 通过负调控 6-磷酸葡萄糖酸脱氢酶 (6PGD) 来抑制前列腺癌转移。

Guchhait Koushik, Yoon Hyeon-Seung, An Hyun-Su, Shin Seungheon, Nam Hye Seung, Yanqui-Rivera Francisco D, Oña Samara M, Mendez Miguel Á, Hwang Jong Yeon, Park Daeho, Park Chul-Seung, Han Jee-Young, Chung Doo Yong, Park Seokjae, Kim Eun-Kyoung, Yang Su-Geun, Cho Steve K

Targeting CRBN With Thalidomide Suppresses Fibrosis After Glaucoma Drainage Surgery Through NF-κB Pathway Inhibition.

通过沙利度胺靶向 CRBN,抑制 NF-κB 通路,从而抑制青光眼引流手术后的纤维化。

Wang Lijun, Li Hongsong, Xiong Lei, Sun Chao, Wang Jianming

Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel cereblon E3 ligase modulators in myeloma

评估 CRBN 突变对骨髓瘤免疫调节药物和新型 cereblon E3 连接酶调节剂疗效的影响

Chrisochoidou, Yakinthi; Scarpino, Andrea; Morales, Salomon; Martin, Shannon; Bird, Sarah; Li, Yigen; Walker, Brian; Caldwell, John; Le Bihan, Yann-Vaï; Pawlyn, Charlotte

A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation.

类似降解子的分子胶驱动 CRBN 同源二聚化和降解。

Langousis Gerasimos, Gainza Pablo, Hunkeler Moritz, Kapsitidou Despoina, Donckele Etienne J, Annunziato Stefano, Wiedmer Lars, Jones Katherine F M, DeMarco Bradley, Quan Chao, Bunker Richard D, Lumb Kevin J, Fasching Bernhard, Castle John C, Townson Sharon A, Bonenfant Débora

A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase

一种鉴定易受 CRBN E3 连接酶泛素化作用影响的小分子/蛋白质对的方法

Cai, Pinwen; Disraeli, Chiara; Sauter, Basilius; Zhanybekova, Saule; Gillingham, Dennis

In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID

利用AirID技术对具有CRBN或VHL结合剂的异双功能分子进行细胞内邻近靶标验证。

Kohdai Yamada,Satoshi Yamanaka,Hiroyuki Yamakoshi,Aki Kohyama,Yoshiharu Iwabuchi,Hidetaka Kosako,Tatsuya Sawasaki

Serum Cereblon (CRBN) Levels Predict Long Term Post- Lenalidomide-Dexamethasone Survival in Multiple Myeloma (MM) Patients and Correlate with Disease Characteristics

血清 Cereblon (CRBN) 水平可预测多发性骨髓瘤 (MM) 患者接受来那度胺-地塞米松治疗后的长期生存率,并与疾病特征相关。

Gkioka, Annita-Ioanna; Gkiokas, Alexandros; Papadatou-Gigante, Mavra; Alexandropoulos, Alexandros; Tryfou, Thomai-Marina; Koudouna, Aspasia; Bartzi, Vasiliki; Kyrtsonis, Marie-Christine

Unraveling the Engagement of Kinases to CRBN Through a Shared Structural Motif to Optimize PROTACs Efficacy

通过共同的结构基序揭示激酶与 CRBN 的相互作用,以优化 PROTAC 的功效

Rosignoli, Serena; Giordani, Sara; Pacelli, Maddalena; Guarguaglini, Giulia; Paiardini, Alessandro

Differential substrate degradation by super-degron: EGFP in wild-type mouse cells, PD-1 requires CRBN humanization

超降解子介导的差异性底物降解:野生型小鼠细胞中的EGFP,PD-1需要CRBN人源化。

Chie Naruse ,Ojiro Ishibashi ,Masatoshi Ohgushi ,Hirohiko Imai ,Tomoko Matsuzaki ,Xuchi Pan ,Tatsuhiko Miyazaki ,Yuka Shidahara ,Yu Shirakawa ,Fumihiro Sugiyama ,Masahide Asano