日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

大环分子胶用于 14-3-3/ChREBP 相互作用：亲和力和协同性呈反比关系

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202521678
Pennings, Marloes A M; van den Bosch, Merel A W; Oberheide, Ansgar; Verhoef, Carlo J A; Ottmann, Christian; Markvoort, Albert J; Miley, Galen P; Brunsveld, Luc
EBP
ChREBP
发表日期：2026
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PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response.

PGC-1α 受 ChREBP 转录调控，通过促进小胶质细胞脂肪酸氧化和抗炎反应来减轻神经性疼痛。

期刊:CNS Neuroscience & Therapeutics
影响因子:5
doi:10.1002/cns.70744
Hu Ziwei, Pang Jiahui, Liu Xinli, Zhao Yun, Lu Yi, Chen Hui, Zeng Hui, Yu Youxin, Zhao Yubai, Gao Lijie, Zhang Xuefei, Jin Jian, Wang Kangling, Shi Yu, Zhan Hongrui, Wu Wen
胶质细胞
ChREBP
表观遗传
信号转导
EBP
代谢
细胞生物学
转录调控
发表日期：2026
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Integrated causal inference, kidney transcriptomics, and experimental validation identify ChREBP (MLXIPL) as a driver of maladaptive metabolic remodeling in diabetic kidney disease

综合因果推断、肾脏转录组学和实验验证，确定 ChREBP (MLXIPL) 是糖尿病肾病中代谢重塑异常的驱动因素。

期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2026.1809567
Liu, Mingliang; Chen, Shihang; Wu, Shi; Sun, Bei; Chen, Liming
糖尿病肾病
糖尿病
代谢
MLXIP
EBP
ChREBP
发表日期：2026
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Retinol saturase promotes tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ChREBP ubiquitination via Smurf2 suppression

视黄醇饱和酶通过抑制Smurf2进而抑制ChREBP泛素化，从而促进糖尿病肾病中的肾小管间质纤维化。

期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2026.1759785
Huang, Heming; Xu, Wei; Wang, Yang; Shi, Yanjia; Tang, Sijing; Fang, Ping; Pan, Lingling; Ye, Zhengqin; Zhou, Yun; Huang, Jieli; Xue, Ying
ChREBP
表观遗传
EBP
泛素化
代谢
糖尿病
糖尿病肾病
发表日期：2026
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The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress Response

E3连接酶RNF8在肝脏应激反应期间促进ChREBPα的泛素化和降解

期刊:FASEB Journal
影响因子:4.2
doi:10.1096/fj.202600106R
Zhao, Yuee; Wang, Sujuan; Zhang, Jian; Cooke, Sarah; Zhang, Gary; Zhao, Zifeng; Oh, Joon; Tong, Xin; Yin, Lei
表观遗传
RNF8
泛素化
EBP
ChREBP
发表日期：2026
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ChREBP-β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4.

ChREBP-β 通过 ATF4 加剧果糖引起的肾小管疾病。

期刊:FASEB Journal
影响因子:4.2
doi:10.1096/fj.202600490R
Fang Ting, Yang Xinyu, Deng Xiaoqing, Wang Jingyi, Li Ting, Guo Hang, Sun Bei, Chen Liming
EBP
ATF4
ChREBP
发表日期：2026
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Deficiency of glycogen synthase promotes lipid accumulation through ChREBP and AKT-mTOR1-SREBP1 axis activation in mice.

糖原合成酶缺乏通过激活 ChREBP 和 AKT-mTOR1-SREBP1 轴促进小鼠体内脂质积累。

期刊:Journal of Lipid Research
影响因子:4.1
doi:10.1016/j.jlr.2025.100962
Li Liangkui, Lang Jianan, Yang Longyan, Zhao Dong
AKT
EBP
MTOR
EBP1
ChREBP
mTOR
发表日期：2026
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Unraveling the role of ChREBP in lung adenocarcinoma: Expression, regulatory networks, and potential functional impact

揭示 ChREBP 在肺腺癌中的作用：表达、调控网络和潜在功能影响

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0347907
Ruangpracha, Athisake; Sae-Lee, Chanachai; Chitta, Pitaksin; Grove, Harald; Jamjuntra, Pranisa; Amornrit, Warisa; Suriyaphol, Prapat; Thuwajit, Chanitra; Poungvarin, Naravat
信号转导
EBP
ChREBP
肿瘤
肿瘤免疫
发表日期：2026
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

甘油-3-磷酸在瓜氨酸缺乏症中激活ChREBP、FGF21转录和脂肪生成

期刊:Nature Metabolism
影响因子:20.8
doi:10.1038/s42255-025-01399-3
Tiwari, Vinod; Jin, Byungchang; Sun, Olivia; Lopez Gonzalez, Edwin D J; Chen, Min-Hsuan; Wu, Xiwei; Shah, Hardik; Zhang, Andrew; Herman, Mark A; Spracklen, Cassandra N; Goodman, Russell P; Brenner, Charles
FGF2
EBP
FGF21
ChREBP
发表日期：2025
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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

调节性ChREBP/14-3-3复合物的分子粘合剂保护β细胞免受糖脂毒性损伤

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-57241-7
Katz, Liora S; Visser, Emira J; Plitzko, Kathrin F; Pennings, Marloes A M; Cossar, Peter J; Tse, Isabelle L; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K
ChREBP
细胞生物学
毒理研究
EBP
发表日期：2025
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