DCLK1相关文献与解析，生知库 | 链接生命科学的每一步

Matrix stiffness induces Ca(2+)-DCLK1-PIP5K1A mechanotransduction as a context-specific amplifier in pancreatic cancer progression and chemotherapy resistance

基质刚度诱导Ca(2+)-DCLK1-PIP5K1A机械转导，在胰腺癌进展和化疗耐药中发挥特异性放大作用。

期刊:Experimental Hematology & Oncology

影响因子:13.5

doi:10.1186/s40164-026-00756-6

Zhang, Haoxiang; Zhao, Chuanbing; Chen, Jiaoshun; Hu, Xiaoqing; Bai, Jianwei; He, Long; Deng, Zanglong; Yin, Tao

Hypoxic stimulation of DCLK1 transcription and alternative-promoter switching fuels tumor malignancy in clear cell renal cell carcinoma

缺氧刺激DCLK1转录和启动子替代转换促进透明细胞肾细胞癌的肿瘤恶性进展

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-07916-2

Yao, Jiannan; Huang, Xuying; Sun, Qianqian; Zhao, Wenjing; Weygant, Nathaniel; Fan, Xiaona; Liu, Heshu; Xiao, Zeru; Yan, Rui; Ge, Yang; An, Guangyu; Liu, Jian

Balancing Regeneration and Resistance: Targeting DCLK1 to Mitigate Gastrointestinal Radiation Injury and Oncogenesis

平衡再生与抵抗：靶向DCLK1以减轻胃肠道放射损伤和肿瘤发生

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers17122050

Moore, Landon L; Jaboin, Jerry; Brown, Milton L; Houchen, Courtney W

A novel D-peptide modulates DCLK1 gelsolin interactions, reducing PDAC tumor growth.

一种新型 D 肽调节 DCLK1 凝溶胶蛋白相互作用，从而减少 PDAC 肿瘤生长。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-19722-z

Moore Landon L, Qu Dongfeng, Chandrekesan Parthasarathy, Pitts Kamille, May Randal, Anderson Byron E, Brown Milton L, Houchen Courtney W

Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody

利用新制备的单克隆抗体研究DCLK1“S”亚型在不同胃癌亚型中的临床意义

期刊:Cancer Biomarkers

影响因子:1.9

doi:10.1177/18758592241301691

Razmi, Mahdieh; Bayat, Ali-Ahmad; Mortazavi, Nafiseh; Kalantari, Elham; Saeednejad Zanjani, Leili; Saki, Sima; Ghods, Roya; Madjd, Zahra

Highlighting the Role of DCLK1 in Tumor Invasion and Potential for Therapeutic Intervention

强调DCLK1在肿瘤侵袭中的作用及其潜在的治疗干预价值

期刊:

影响因子:

doi:10.33696/cancerimmunol.7.116

Muehlebach, Molly E; Thomas, Sufi Mary

DCLK1 mediated cooperative acceleration of EMT by avian leukosis virus subgroup J and Marek's disease virus via the Wnt/β-catenin pathway promotes tumor metastasis

DCLK1介导的禽白血病病毒J亚群和马立克氏病病毒通过Wnt/β-catenin通路协同加速EMT，促进肿瘤转移。

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/jvi.01112-24

Zhou, Jing; Zhou, Defang; Zhang, Qian; Zhang, Xinyue; Liu, Xiaoyang; Ding, Longying; Wen, Jing; Xu, Xiaoyu; Cheng, Ziqiang

The doublecortin-family kinase ZYG-8DCLK1 regulates microtubule dynamics and motor-driven forces to promote the stability of C. elegans acentrosomal spindles

双皮质素家族激酶ZYG-8DCLK1调节微管动力学和马达驱动力，从而促进秀丽隐杆线虫无中心体纺锤体的稳定性。

期刊:PLoS Genetics

影响因子:3.7

doi:10.1371/journal.pgen.1011373

Czajkowski, Emily R; Zou, Yuntong; Divekar, Nikita S; Wignall, Sarah M

Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses

巨噬细胞DCLK1通过与IKKβ结合并诱导炎症反应来促进动脉粥样硬化。

期刊:EMBO Molecular Medicine

影响因子:9

doi:10.15252/emmm.202217198

Zhuqi Huang,Sirui Shen,Xue Han,Weixin Li,Wu Luo,Liming Lin,Mingjiang Xu,Yi Wang,Weijian Huang,Gaojun Wu,Guang Liang

DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6.

DCLK1 通过去泛素化 HDAC6 来驱动膀胱癌的恶性进展和化疗耐药性。

Matrix stiffness induces Ca(2+)-DCLK1-PIP5K1A mechanotransduction as a context-specific amplifier in pancreatic cancer progression and chemotherapy resistance

基质刚度诱导Ca(2+)-DCLK1-PIP5K1A机械转导，在胰腺癌进展和化疗耐药中发挥特异性放大作用。

Hypoxic stimulation of DCLK1 transcription and alternative-promoter switching fuels tumor malignancy in clear cell renal cell carcinoma

缺氧刺激DCLK1转录和启动子替代转换促进透明细胞肾细胞癌的肿瘤恶性进展

Balancing Regeneration and Resistance: Targeting DCLK1 to Mitigate Gastrointestinal Radiation Injury and Oncogenesis

平衡再生与抵抗：靶向DCLK1以减轻胃肠道放射损伤和肿瘤发生

A novel D-peptide modulates DCLK1 gelsolin interactions, reducing PDAC tumor growth.

一种新型 D 肽调节 DCLK1 凝溶胶蛋白相互作用，从而减少 PDAC 肿瘤生长。

Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody

利用新制备的单克隆抗体研究DCLK1“S”亚型在不同胃癌亚型中的临床意义

Highlighting the Role of DCLK1 in Tumor Invasion and Potential for Therapeutic Intervention

强调DCLK1在肿瘤侵袭中的作用及其潜在的治疗干预价值

DCLK1 mediated cooperative acceleration of EMT by avian leukosis virus subgroup J and Marek's disease virus via the Wnt/β-catenin pathway promotes tumor metastasis

DCLK1介导的禽白血病病毒J亚群和马立克氏病病毒通过Wnt/β-catenin通路协同加速EMT，促进肿瘤转移。

The doublecortin-family kinase ZYG-8DCLK1 regulates microtubule dynamics and motor-driven forces to promote the stability of C. elegans acentrosomal spindles

双皮质素家族激酶ZYG-8DCLK1调节微管动力学和马达驱动力，从而促进秀丽隐杆线虫无中心体纺锤体的稳定性。

Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses

巨噬细胞DCLK1通过与IKKβ结合并诱导炎症反应来促进动脉粥样硬化。