日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.

胞质 DHODH 的异位表达使嘧啶从头合成与线粒体电子传递脱钩。

Curtabbi Andrea, Jaroszewicz Sara Natalia, Sanz-Cortés Rocío, Acín-Pérez Rebeca, Prymidis Dimitrios, Cherevatenko Maksym, Martínez-de-Mena Raquel, Esteban-Amo María Jesús, de la Fuente Miguel A, Frezza Christian, Enríquez José Antonio

DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.

DHODH 将线粒体生物能量学、一碳代谢和 DNA 修复联系起来,以维持侵袭性前列腺腺癌。

Rajaratnam Saiswaroop, Piyarathna Danthasinghe Waduge Badrajee, Mehta Ranjit K, Mekala Venugopalareddy, Park Jun Hyoung, Rasaily Uttam, Venkatappa Vani, Kami Reddy Karthik Reddy, Putluri Vasanta, Goel Kaveri, Grimm Sandra L, Thota Sai Manohar, Morrison Taylor, Coarfa Cristian, Kaipparettu Benny Abraham, Cheng Chao, Putluri Nagireddy, Jones Jeffrey A, Nyati Mukesh K, Ittmann Michael, Gassman Natalie R, Sreekumar Arun

Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cycles

靶向DHODH揭示了AR阳性和AR阴性前列腺癌细胞通过嘧啶合成以及与TCA循环和尿素循环的代谢串扰而存在的代谢脆弱性。

Labroy, Maxime; Paré, Marc-Oliver; Berthiaume, Line; Thomas, Mélissa; Jobin, Cynthia; Veilleux, Alain; Pelletier, Martin; Pouliot, Frédéric; Masson, Jean-Yves; Audet-Walsh, Étienne

Targeting the NSUN2-DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer.

靶向 NSUN2-DHODH 轴可逆转结直肠癌的铁死亡抵抗和奥沙利铂抵抗。

Zhang Junyi, Shen Junxiao, Zeng Tangye, Gao Chang, Sheng Biao, Li Junliang, Zeng Weiqi, Shen Jieyi, Shen Chong, Wang Jiaojiao, Wang Jianwei

Quinazolinones as Bioisosteres of Naphthoquinones: A Path to Potent HsDHODH Inhibitors with Optimized Properties

喹唑啉酮作为萘醌的生物等排体:获得具有优化性能的高效HsDHODH抑制剂的途径

Godoi, Bruna F; Bueno, Jéssica D; Silva, Wemenes J L; da Purificação, Aline D; Leite, Pedro I P; Dos Santos, Thiago; Freitas, Murillo; Silva, Daniel G; Silva, Tais C; de Moraes, Josué; Freitas, Caroline S; Mattos, Mayara; Souza, Thiago M L; Martin, Bianca A; Lopez, Renata F V; Nonato, M Cristina; Andrade, Carolina H; Emery, Flavio S

Development of DHODH inhibitors incorporating virtual screening, pharmacophore modeling, fragment-based optimization methods, ADMET, molecular docking, molecular dynamics, PCA analysis, and free energy landscape

结合虚拟筛选、药效团建模、基于片段的优化方法、ADMET、分子对接、分子动力学、PCA分析和自由能景观研究,开发DHODH抑制剂。

Wang, Qu; Xu, Yu Hao; Jiang, Heng; Deng, Biao; Liang, Zhu

BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia

BCOR 突变决定了急性髓系白血病对 DHODH 抑制剂的治疗敏感性。

Robert, Florian; Badja, Cherif; Boushaki, Soraya; Degasperi, Andrea; Memari, Yasin; Momen, Sophie; Roumeliotis, Theodoros I; Kozik, Zuza; Gozdecka, Malgorzata; Choudhary, Jyoti; Vassiliou, George; Koh, Gene Cc; Nik-Zainal, Serena

NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy.

NK-A 17E-233I:一种新型的人类二氢乳清酸脱氢酶 (DHODH) 竞争性抑制剂,用于癌症治疗。

DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target

DHODH介导的线粒体氧化还原稳态:一种新型铁死亡调节因子和有前景的治疗靶点

Cao, Jinghao; Chen, Xi; Chen, Lulu; Lu, Yajuan; Wu, Yunyi; Deng, Aoli; Pan, Feifan; Huang, Hangqi; Liu, Yingchao; Li, Yanchun; Tong, Xiangmin; Du, Jing

Fluorescent Isostere (Fluostere) of the Carboxylate: Design of hDHODH Fluorescent Inhibitors as Proof of Concept

羧酸盐的荧光等排体(Fluostere):hDHODH荧光抑制剂的设计及其概念验证

Sainas, Stefano; Martino, Elena; Garino, Claudio; Circosta, Paola; Luganini, Anna; Giorgis, Marta; Bavo, Francesco; Piccinini, Marco; Ramondetti, Cristina; Alberti, Marta; Miggiano, Riccardo; Gribaudo, Giorgio; Boschi, Donatella; Frølund, Bente; Lolli, Marco Lucio