日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs

DNA-PKcs抑制剂AZD7648揭示了sgRNA交叉污染,并增强了造血干细胞中基因组工程脱靶活性的敏感性

White, Nathan; Hu, Yi-Ting; Chalk, John Alexander; Kurgan, Gavin; Naseem, Asma; Schmaljohn, Ellen; Sturgeon, Morgan; Cavazza, Alessia; Thrasher, Adrian James; Turchiano, Giandomenico

DNA-PKcs promotes therapy resistance and metastatic recurrence in neuroblastoma

DNA-PKcs促进神经母细胞瘤的治疗耐药性和转移复发

Norouzi, Mahnaz; Kim, Subin; Zhu, Beibei; Wang, Chi; Wu, Natalie; Somers, Katherine; Yang, Eddy Shih-Hsin; Mark Evers, B; Rellinger, Eric J; Rychahou, Piotr

DNA-PKcs orchestrates CTLA-4 depletion-induced senescence in cancer cells

DNA-PKcs 调控 CTLA-4 耗竭诱导的癌细胞衰老

Lee, Je-Jung; Rhee, Woo Joong; Kim, So Young; Lee, Jisun; Jung, Su Ful; Oh, Jooyeon; Park, In Ho; Shin, Jeon-Soo

DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling.

DNA-PKcs 通过调节 LAT 依赖性信号传导来控制细胞毒性 T 细胞对癌症和移植同种异体移植物的反应。

Rainwater Randall R, Azevedo-Pouly Ana C, Waldrip Zachary J, Hicks Belle H, Callais Nicholas A, Koss Brian, Storey Aaron J, Burdine Lyle, Burdine Marie Schluterman

Epigenetic silencing L3MBTL4 sensitizes esophageal cancer to DNA-PKcs inhibitor.

表观遗传沉默 L3MBTL4 使食管癌对 DNA-PKcs 抑制剂敏感。

Li Yuan, Gao Aiai, Yao Yuanxin, Zhang Meiying, Jin Lianlian, Tao Qian, Guo Mingzhou

Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.

使用 HDR 增强型 DNA-PKcs 抑制剂 AZD7648 进行基因组编辑会导致大规模基因组改变。

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.

53BP1-RIF1 和 DNA-PKcs 表现出不同的遗传相互作用,导致不同的染色体断裂修复结果。

Makins Kaela, Cisneros-Aguirre Metztli, Lopezcolorado Felicia Wednesday, Stark Jeremy M

Armadillo domain of ARID1A directly interacts with DNA-PKcs to couple chromatin remodeling with nonhomologous end joining (NHEJ) pathway.

ARID1A 的 Armadillo 结构域直接与 DNA-PKcs 相互作用,将染色质重塑与非同源末端连接 (NHEJ) 途径偶联起来

Kanno Shin-Ichiro, Kobayashi Takayasu, Watanabe Reiko, Kurimasa Akihiro, Tanaka Kozo, Yasui Akira, Ui Ayako

Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination

Senataxin 和 DNA-PKcs 在 V(D)J 重组过程中冗余地促进 DNA 双链断裂的非同源末端连接修复。

Bo-Ruei Chen ,Thu Pham ,Lance D Reynolds ,Nghi Dang ,Yanfeng Zhang ,Kimberly Manalang ,Gabriel Matos-Rodrigues ,Jason Romero Neidigk ,Andre Nussenzweig ,Jessica K Tyler ,Barry P Sleckman

DNA-PKcs, a player winding and dancing with RNA metabolism and diseases

DNA-PKcs,一个与RNA代谢和疾病密切相关的角色

Hou, Jiabao; Lu, Mingjun; Guo, Jingwei; Wu, Jinghong; Wang, Chenyang; Zhou, Ping-Kun; Ma, Teng