日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DOT1L provides transcriptional memory through PRC1.1 antagonism.

DOT1L 通过 PRC1.1 拮抗作用提供转录记忆。

DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID

DOT1L活性限制转录延伸速度,并促进RNAPII暂停,从而促进AID介导的诱变。

Subramani, Poorani Ganesh; Seija, Noé; Ridani, Jana; Boulais, Jonathan; Donnelly, Paul A; Provencher, Mélanie; Bagci, Halil; Poitras, Christian; Côté, Jean-François; Robert, François; Di Noia, Javier M

Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder

DOT1L 的缺失会扰乱神经元转录,并导致神经发育障碍。

Maroni, Marissa J; Barton, Melissa; Lynch, Katherine; Deshwar, Ashish R; Campbell, Philip D; Millard, Josephine; Lee, Rachel; Cohen, Annastelle; Ahmad, Rili; Paranjapye, Alekh; Faundes, Víctor; Repetto, Gabriela M; McKenna, Caoimhe; Shillington, Amelle L; Phornphutkul, Chanika; Hove, Hanne B; Mancini, Grazia M S; Schot, Rachel; Barakat, Tahsin Stefan; Richmond, Christopher M; Lauzon, Julie; Ibrahim, Ahmed Ibrahim Elsayed; Nava, Caroline; Héron, Delphine; van Aalst, Minke M A; Atemin, Slavena; Sleptsova, Mila; Aleksandrova, Iliyana; Todorova, Albena; Watkins, Debra L; Kozenko, Mariya A; Natera-de Benito, Daniel; Ortez, Carlos; Estevez-Arias, Berta; Lecoquierre, François; Cassinari, Kévin; Guerrot, Anne-Marie; Levy, Jonathan; Latypova, Xenia; Verloes, Alain; Innes, A Micheil; Yang, Xiao-Ru; Banka, Siddharth; Vill, Katharina; Jacob, Maureen; Kruer, Michael; Skidmore, Peter; Galaz-Montoya, Carolina I; Bakhtiari, Somayeh; Mester, Jessica L; Granato, Michael; Armache, Karim-Jean; Costain, Gregory; Korb, Erica

Identification of LncRNAs scaffolding a chromatin-associated gene regulatory complex in breast cancer cells comprising ERα, DOT1L and menin.

鉴定乳腺癌细胞中由 ERα、DOT1L 和 menin 组成的染色质相关基因调控复合物的支架 LncRNA。

Melone Viola, Salvati Annamaria, Palo Luigi, Palumbo Domenico, Memoli Domenico, Ianniello Maria, Nikzaban Mehrnoush, Casaburi Aurora, Lamberti Jessica, Rizzo Francesca, Weisz Alessandro, Nassa Giovanni, Tarallo Roberta

DOT1L promotes immune evasion in lung adenocarcinoma through H3K79me2-mediated epigenetic activation of immune checkpoints.

DOT1L 通过 H3K79me2 介导的免疫检查点表观遗传激活促进肺腺癌的免疫逃逸。

The role of DOT1L in the proliferation and prognosis of gastric cancer

DOT1L在胃癌增殖和预后中的作用

Qian, Jun; Song, Zaozhi; Wei, Zhuoli; Wang, Qingkang; Zhang, Xinxin; Tao, Xiaoying; Wu, Nan; Liu, Xue

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

组蛋白甲基转移酶DOT1L对树突状细胞亚群的发育具有差异性影响

Bouma, Rianne G; de Leeuw, Willem-Jan; Wang, Aru Z; Malik, Muddassir; Stolwijk, Joeke Gc; Konijn, Veronique Al; Mensink, Anne; Proost, Natalie; Nijen Twilhaar, Maarten K; van Welsem, Tibor; Seyed Toutounchi, Negisa; Affandi, Alsya J; van Dinter, Jip T; van Leeuwen, Fred; den Haan, Joke Mm

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

ERG驱动的前列腺癌起始依赖于细胞环境,并且需要KMT2A和DOT1L。

Weiran Feng # ,Erik Ladewig # ,Matthew Lange ,Nazifa Salsabeel ,Huiyong Zhao ,Young Sun Lee ,Anuradha Gopalan ,Hanzhi Luo ,Wenfei Kang ,Ning Fan ,Eric Rosiek ,Elisa de Stanchina ,Yu Chen ,Brett S Carver ,Christina S Leslie ,Charles L Sawyers

DOT1L Mediates Stem Cell Maintenance and Represents a Therapeutic Vulnerability in Cancer

DOT1L介导干细胞维持,并代表癌症治疗中的一个薄弱环节。

Kurani, Hetakshi; Slingerland, Joyce M

Inhibition of EYA family tyrosine phosphatase activity reveals a therapeutic vulnerability and enhances Menin and DOT1L inhibitor efficacy in KMT2A-rearranged leukemia

抑制EYA家族酪氨酸磷酸酶活性揭示了KMT2A重排白血病的治疗弱点,并增强了Menin和DOT1L抑制剂的疗效。

Badmus, Lola; Achille, Nicholas J; Zhang, Shubin; Ding, Xianzhong; Zeleznik-Le, Nancy J