日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.

靶向 NAT10 可破坏 DYRK1A 的 N4-乙酰化,从而缓解结肠衰老和老年性结肠炎。

Chen Jingyu, Xue Meng, Mi Shuyi, Fu Anbo, Chen Wenwen, Sun Yuhao, Xia Shenglong, Ge Qiwei, Luo Jiakai, Yu Qiao, Wang Liangjing, Chen Shujie

Induction of cellular senescence by androgen receptor agonist or antagonist is mediated via two novel common DYRK1A-DREAM and cyclin G2 signaling pathways in castration-resistant prostate cancer

在去势抵抗性前列腺癌中,雄激素受体激动剂或拮抗剂诱导细胞衰老是通过两条新的共同信号通路介导的,这两条通路分别是DYRK1A-DREAM和细胞周期蛋白G2信号通路。

Atri Roozbahani, Golnaz; Heidari Horestani, Mehdi; Schindler, Katrin; Kallenbach, Julia; Baniahmad, Aria

Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in a Drosophila model of fragile X syndrome

在脆性X综合征的果蝇模型中,Minibrain/DYRK1A的上调导致巨头畸形和脑过度生长。

Colt, Mark; Gordon, Alicia; Peng, Yi-Jheng; Wu, Ying; Martin, Katherine; Chang, Karen T

ZRMQ-22, a novel DYRK1A inhibitor, attenuates neuroinflammation and cognitive impairments in LPS-induced mice: a potential strategy for Alzheimer's disease

ZRMQ-22 是一种新型 DYRK1A 抑制剂,可减轻 LPS 诱导小鼠的神经炎症和认知障碍:一种潜在的阿尔茨海默病治疗策略。

Mengyu Ren,Huanhua Chen,Zhenshu Li,Jiacheng Zhuang,Aizhu Yang,Xiangdong Li,Xinyu Li,Xinpeng Wang,Zonghe Xu,Xianghuan Liu,Jiawen Song,Tianhao Jiang,Zihua Xu,Xudong Gao,Qingchun Zhao

Serial PNA-Transformer-Based Virtual Screening Identifies Nanomolar DYRK1A Inhibitors for Pancreatic Ductal Adenocarcinoma

基于PNA-Transformer的串行虚拟筛选鉴定出用于治疗胰腺导管腺癌的纳摩尔级DYRK1A抑制剂

Zhang, Hongyu; Wang, Ke; Wu, Xiaochuan; Zhou, Rui; Li, Chaofeng; Cai, Xiuyu; Zhuang, Yanyan

Correction: DYRK1A roles in human neural progenitors

更正:DYRK1A 在人类神经祖细胞中的作用

Courraud, Jeremie; Quartier, Angélique; Drouot, Nathalie; Zapata-Bodalo, Irene; Gilet, Johan; Benchoua, Alexandra; Mandel, Jean-Louis; Piton, Amélie

Editorial: Advances in DYRK1A syndrome: underlying mechanisms, disease models, and novel therapeutic approaches

社论:DYRK1A综合征研究进展:潜在机制、疾病模型和新型治疗方法

Glass, Oliver K; Piton, Amelie; Pfalzer, Anna

Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells

Leucettinib-21 可降低 DYRK1A 在人类 21 三体 iPSC 衍生神经细胞中的剂量效应

West, Nicole R; Lindberg, Mattias F; Dairou, Julien; MacGregor, Shawn; Puthireddy, Sahith; Meijer, Laurent; Bhattacharyya, Anita

Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A

染色体碎裂相关21号染色体扩增通过DYRK1A的靶向过表达调控MPN向急变期转化

Charlotte K Brierley #,Bon Ham Yip #,Giulia Orlando #,Jeremy Wen,Sean Wen,Harsh Goyal,Max Levine,G Maria Jakobsdottir,Avraam Tapinos,Alex J Cornish,Antonio Rodriguez-Romera,Alba Rodriguez-Meira,Matthew Bashton,Angela Hamblin,Sally Ann Clark,Joseph C Hamley,Olivia Fox,Madalina Giurgiu,Jennifer O'Sullivan,Lauren Murphy,Assunta Adamo,Aude Anais Olijnik,Anitria Cotton,Emily Hendrix,Shilpa Narina,Shondra M Pruett-Miller,Amir Enshaei,Claire Harrison,Mark Drummond,Steven Knapper,Ayalew Tefferi,Iléana Antony-Debré,James Davies,Anton G Henssen,Supat Thongjuea,David C Wedge,Stefan N Constantinescu,Elli Papaemmanuil,Bethan Psaila,John D Crispino,Adam J Mead

DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition

DYRK1A抑制导致MYC和ERK激活,使KMT2A-R急性淋巴细胞白血病细胞对BCL2抑制敏感。

Ayyadevara, V S S Abhinav; Wertheim, Gerald; Gaur, Shikha; Chukinas, John A; Loftus, Joseph P; Lee, Sung June; Kumar, Anil; Swaminathan, Srividya; Bhansali, Rahul S; Childers, Wayne; Geng, Huimin; Milne, Thomas A; Hua, Xianxin; Bernt, Kathrin M; Besson, Thierry; Shi, Junwei; Crispino, John D; Carroll, Martin; Tasian, Sarah K; Hurtz, Christian