ECHA相关文献与解析，生知库 | 链接生命科学的每一步

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA's RAAF, and good read-across practice

机制性交叉参照日趋成熟：对 EFSA 2025 指南、ECHA 的 RAAF 和良好交叉参照实践的比较评估

期刊:Frontiers in Toxicology

影响因子:4.6

doi:10.3389/ftox.2025.1690491

Hartung, Thomas; Rovida, Costanza

ECHA

发表日期：2025

文献求助收藏

Modulators of Energy Expenditure Accuracy in Adults with Overweight or Obesity: E-MECHANIC Secondary Analyses

超重或肥胖成年人能量消耗准确性的调节因素：E-MECHANIC 二次分析

期刊:Medicine and Science in Sports and Exercise

影响因子:3.9

doi:10.1249/MSS.0000000000003583

Matthews, Rachel; Höchsmann, Christoph; Erickson, Melissa L; Dorling, James L; Spielmann, Guillaume; Johannsen, Neil M; Church, Timothy S; Martin, Corby K

Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy

肝细胞内在 SMN 缺乏导致脊髓性肌萎缩症中的代谢功能障碍和肝脏脂肪变性

期刊:Journal of Clinical Investigation

影响因子:13.3

doi:10.1172/JCI173702

Damien Meng-Kiat Leow, Yang Kai Ng, Loo Chien Wang, Hiromi Wl Koh, Tianyun Zhao, Zi Jian Khong, Tommaso Tabaglio, Gunaseelan Narayanan, Richard M Giadone, Radoslaw M Sobota, Shi-Yan Ng, Adrian Kk Teo, Simon H Parson, Lee L Rubin, Wei-Yi Ong, Basil T Darras, Crystal Jj Yeo

ECHA ARN documents: chemical grouping without a toxicological rationale

ECHA ARN 文件：缺乏毒理学依据的化学品分组

期刊:Archives of Toxicology

影响因子:6.9

doi:10.1007/s00204-023-03479-3

Natsch, Andreas; Adamsson, Greg; Rocha, Vanessa

ECHA

发表日期：2023

文献求助收藏

Can regulatory T cells improve outcomes of sensitised patients after HLA-Ab incompatible renal transplantation: study protocol for the Phase IIa GAMECHANgER-1 trial

调节性T细胞能否改善HLA-Ab不相容肾移植后致敏患者的预后：IIa期GAMECHANgER-1试验的研究方案

期刊:BMC Nephrology

影响因子:2.4

doi:10.1186/s12882-023-03157-7

Dudreuilh, C; Jarvis, P; Beadle, N; Pilecka, I; Shaw, O; Gardner, L; Scottà, C; Mamode, N; Game, D S; Sanchez-Fueyo, A; Lombardi, G; Learoyd, A; Douiri, A; Dorling, A

A serial optical frequency-domain imaging study of early and late vascular responses to bioresorbable-polymer sirolimus-eluting stents for the treatment of acute myocardial infarction and stable coronary artery disease patients: results of the MECHANISM-ULTIMASTER study

一项针对急性心肌梗死和稳定性冠状动脉疾病患者，采用生物可吸收聚合物西罗莫司洗脱支架治疗后早期和晚期血管反应的系列光学频域成像研究：MECHANISM-ULTIMASTER 研究结果

期刊:Cardiovascular Intervention and Therapeutics

影响因子:5.8

doi:10.1007/s12928-021-00777-4

Itoh, Tomonori; Otake, Hiromasa; Kimura, Takumi; Tsukiyama, Yoshiro; Kikuchi, Tatsuo; Okubo, Munenori; Hayashi, Takatoshi; Okamura, Takayuki; Kuramitsu, Shoichi; Morita, Takashi; Sonoda, Shinjo; Ishihara, Shozo; Kuriyama, Nehiro; Isshiki, Takaaki; Soeda, Tsunenari; Hibi, Kiyoshi; Shinke, Toshiro; Morino, Yoshihiro

Assessment of endocrine disruptive properties of PFOS: EFSA/ECHA guidance case study utilising AOP networks and alternative methods

PFOS内分泌干扰特性评估：EFSA/ECHA指南案例研究，采用AOP网络和替代方法

期刊:EFSA Journal

影响因子:3.3

doi:10.2903/j.efsa.2022.e200418

Pípal, Marek; Wiklund, Linus; Caccia, Sara; Beronius, Anna

LIVECHART Patient-Reported Outcome Tool for Botulinum Toxin Treatment in Cervical Dystonia

用于评估肉毒杆菌毒素治疗颈肌张力障碍的 LIVECHART 患者报告结局工具

期刊:Movement Disorders Clinical Practice

影响因子:2.7

doi:10.1002/mdc3.13401

Chueluecha, Chuenchom; Moore, Austen Peter

ECHA

发表日期：2022

文献求助收藏

Biosynthesis of a sulfated exopolysaccharide, synechan, and bloom formation in the model cyanobacterium Synechocystis sp. strain PCC 6803

模式蓝藻集胞藻（Synechocystis sp.）PCC 6803菌株中硫酸化胞外多糖、聚球藻多糖（synechan）的生物合成及水华形成

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.66538.

Kaisei Maeda,Yukiko Okuda,Gen Enomoto,Satoru Watanabe,Masahiko Ikeuchi

ECHA

发表日期：2021

文献求助收藏

Regulation of Myogenesis by MechanomiR-200c/FoxO3 Axis.

MechanomiR-200c/FoxO3轴对肌生成的调控。

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA's RAAF, and good read-across practice

机制性交叉参照日趋成熟：对 EFSA 2025 指南、ECHA 的 RAAF 和良好交叉参照实践的比较评估

Modulators of Energy Expenditure Accuracy in Adults with Overweight or Obesity: E-MECHANIC Secondary Analyses

超重或肥胖成年人能量消耗准确性的调节因素：E-MECHANIC 二次分析

Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy

肝细胞内在 SMN 缺乏导致脊髓性肌萎缩症中的代谢功能障碍和肝脏脂肪变性

ECHA ARN documents: chemical grouping without a toxicological rationale

ECHA ARN 文件：缺乏毒理学依据的化学品分组

Can regulatory T cells improve outcomes of sensitised patients after HLA-Ab incompatible renal transplantation: study protocol for the Phase IIa GAMECHANgER-1 trial

调节性T细胞能否改善HLA-Ab不相容肾移植后致敏患者的预后：IIa期GAMECHANgER-1试验的研究方案

A serial optical frequency-domain imaging study of early and late vascular responses to bioresorbable-polymer sirolimus-eluting stents for the treatment of acute myocardial infarction and stable coronary artery disease patients: results of the MECHANISM-ULTIMASTER study

一项针对急性心肌梗死和稳定性冠状动脉疾病患者，采用生物可吸收聚合物西罗莫司洗脱支架治疗后早期和晚期血管反应的系列光学频域成像研究：MECHANISM-ULTIMASTER 研究结果

Assessment of endocrine disruptive properties of PFOS: EFSA/ECHA guidance case study utilising AOP networks and alternative methods

PFOS内分泌干扰特性评估：EFSA/ECHA指南案例研究，采用AOP网络和替代方法

LIVECHART Patient-Reported Outcome Tool for Botulinum Toxin Treatment in Cervical Dystonia

用于评估肉毒杆菌毒素治疗颈肌张力障碍的 LIVECHART 患者报告结局工具

Biosynthesis of a sulfated exopolysaccharide, synechan, and bloom formation in the model cyanobacterium Synechocystis sp. strain PCC 6803

模式蓝藻集胞藻（Synechocystis sp.）PCC 6803菌株中硫酸化胞外多糖、聚球藻多糖（synechan）的生物合成及水华形成