日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia.

ENPP1抑制剂作为治疗迟发性低磷酸酶症的一种方法。

Narisawa Sonoko, Amadeu de Oliveira Flavia, Tokuhara Cintia Kazuko, Lira Dos Santos Elis J, Fonfria Elena, Batson Jennifer, Cheng Zhiliang, Houston Ann, Foster Brian L, Millán José Luis

Interaction between ENPP1 and homologous recombination deficiency defines distinct pan-cancer signatures: A retrospective observational study

ENPP1与同源重组缺陷的相互作用定义了不同的泛癌特征:一项回顾性观察研究

Kim, Yong Min; Lee, Sung Hak; Na, Woong; Lee, Il Ju; Kwon, Mihye; Jo, Oyeon; Song, Young Soo

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

ENPP1缓冲棕色脂肪组织中的细胞外cGAMP,从而限制胰岛素抵抗。

Wang, Songnan; Guo, Yingjie; An, Weidong; Lee, Michelle; Li, Yu; Sudaryo, Valentino; Grenot, Gabriel; Skariah, Gemini; Reghupaty, Saranya C; Young, Sonny; Bai, Xiaochen; Svensson, Katrin J; Li, Lingyin

Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer

ENPP1/ATM双重缺失会削弱DNA损伤修复,从而增强放射免疫疗法对三阴性乳腺癌的疗效。

Ruiz-Fernández de Córdoba, Borja; Valencia, Karmele; Welch, Connor; Moreno, Haritz; Martínez-Canarias, Susana; Zandueta, Carolina; Gómez, Eduardo; Calvo, Alfonso; Otegui, Nerea; Echepare, Mirari; Garzón, Ignacio; Ajona, Daniel; Lara-Astiaso, David; Guruceaga, Elisabeth; Guembe, Laura; Pío, Rubén; Melero, Ignacio; Vicent, Silve; Pastor, Fernando; Martínez-Monge, Rafael; Lecanda, Fernando

Genome-wide association study in chondrocalcinosis reveals ENPP1 as a candidate therapeutic target in calcium pyrophosphate deposition disease

全基因组关联研究揭示ENPP1是软骨钙质沉着症的潜在治疗靶点。

Takei, Riku; Rosenthal, Ann; Pascart, Tristan; Reynolds, Richard J; Neogi, Tuhina; Terkeltaub, Robert; Tedeschi, Sara K; Merriman, Tony R

ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in human epidermal growth factor receptor 2-positive breast cancer

ENPP1诱导血脑屏障功能障碍并促进人表皮生长因子受体2阳性乳腺癌脑转移的形成

Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R S; Almeida, Sara F F; Ciputra, Edward; Sereno, José; Almeida, Rui; Teixeira, Paulo; Ribeiro, Ana Sofia; Moreira, João N; Silva, Ana P; Ferreira, Lino; Abrunhosa, Antero J; Gomes, Célia M

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

ENPP1抑制剂具有超长的药物靶点停留时间,可作为一种先天免疫检查点阻断疗法用于癌症治疗。

Songnan Wang ,Randolph M Johnson ,Jacqueline A Carozza ,Daniel Fernandez ,Jan Scicinski ,Neil A Verity ,Rachel Mardjuki ,Xujun Cao ,Yingjie Guo ,Jacqueline Papkoff ,Nigel Ray ,Lingyin Li

JUN-ENPP1-cGAS-STING axis mediates immune evasion and tumor progression in bladder cancer

JUN-ENPP1-cGAS-STING轴介导膀胱癌的免疫逃逸和肿瘤进展

You, Chengyu; Fang, Qixiang; Qing, Liangliang; Xiao, Xi; Liu, Yang; Yang, Weiguang; Li, Qingchao; Li, Rongxin; Wang, Yanan; Dong, Zhilong

The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice.

ENPP1 缺乏症在患有 OPLL 的人类中的患病率以及 ENPP1 酶疗法在 OPLL 小鼠中的临床前疗效。

Srivastava Shivani, Kato Hajime, von Kroge Simon, Weise Keith, Stabach Paul, Lopez Sam G, O'Brien Kevin, Lester Ethan R, Kim Hana, Ishaq Tayyaba, Dammen-Brower Kris, Schinke Thorsten, Kimura Soichiro, Miyahara Junya, Doi Toru, Oshima Yasushi, Yarema Kevin J, Carpenter Thomas O, Sabbagh Yves, Tommasini Steven M, Ito Nobuaki, Oheim Ralf, Braddock Demetrios T

Improvements in hearing loss with bone-targeted enzyme replacement therapy are associated with corrected hypomineralization and osteocyte properties of auditory ossicles in Enpp1-deficient mice

在Enpp1缺陷小鼠中,通过骨靶向酶替代疗法改善听力损失与听小骨矿化不足和骨细胞特性的纠正有关。

Ana Ocokoljic ,Shivani Srivastava ,Simon von Kroge ,Paul R Stabach ,Björn Busse ,Keith Weise ,Ralf Oheim ,Tim Rolvien ,Demetrios T Braddock