EP300相关文献与解析，生知库 | 链接生命科学的每一步

EP300 promotes hepatocellular carcinoma proliferation, migration and in vivo tumorigenicity revealed by integrated experimental and bioinformatic analyses

综合实验和生物信息学分析揭示EP300促进肝细胞癌的增殖、迁移和体内致瘤性

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-026-07768-0

Liu, Zhipeng; Wang, Junbin; Wu, Xia; Shi, Hong; Ding, Youming; Liu, Xuejian

EP300/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia.

EP300/YAP1-SERPINE1 信号通路调节胆道闭锁中的胆管反应和肝纤维化。

期刊:Cellular and Molecular Gastroenterology and Hepatology

影响因子:7.4

doi:10.1016/j.jcmgh.2025.101640

Zhu Zhongxian, Lu Changgui, Lv Xiaofeng, Lu Yao, Zhu Wei, Zhu Yufei, Zhang Ruyi, Ding Zequan, Xie Hua, Tang Weibing

Curcumin inhibits glycolysis via EP300 in oral squamous cell carcinoma

姜黄素通过EP300抑制口腔鳞状细胞癌中的糖酵解

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-44496-3

Tan, Wanrong; Zhang, Chao; Han, Li; Fu, Haoxuan; Mao, Zhouhong; Zhang, Yongheng; Liu, Ying; Li, Lihua; Yu, Jie

EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis

EP300 通过 YY1/GPX4 轴减弱铁死亡，并刺激瘢痕疙瘩成纤维细胞的增殖、迁移和纤维化。

期刊:Cell Cycle

影响因子:3.4

doi:10.1080/15384101.2026.2627885

Jin, Jun; Wang, Kai; Lu, Chenxi; Yao, Chenghao; Xie, Feng

EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection.

EP300 缺陷会导致慢性复制压力，这是由于复制叉保护缺陷所致。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-67171-z

Barreto-Galvez Angelica, Niljikar Mrunmai, Gagliardi Julia Elizabeth, Guzman Carolina Plasencia, Zhang Ranran, Kumar Vasudha, Juwarwala Aastha, Pradeep Archana, Saxena Ankit, Montagna Cristina, Mittal Priya, Gerhardt Jeannine, Xia Bing, Cao Jian, Kataoka Keisuke, Durbin Adam David, Qi Jun, Ye B Hilda, Madireddy Advaitha

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A-Driven EP300 Expression

H3K27ac对于人类原始多能性至关重要，而这种多能性受m6A驱动的EP300表达调控。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202507549

An, Chenrui; Zhong, Ke; Kang, Xiangjin; Zhang, Yingying; Shang, Yudan; Liu, Hao; Ji, Yushan; Zeng, Jinbei; Lin, Jiajin; Jin, Long; Lin, Zelong; Yu, Yang; Shi, Xuetao; Fan, Yong

EP300 compromises antitumor immunity by increasing SOCS1 expression

EP300 通过增加 SOCS1 表达来削弱抗肿瘤免疫力。

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.3

doi:10.1136/jitc-2025-011488

Yanqiong Zeng,Ying Zhou,Jiayin Ruan,Wancheng Liu,Huimin Fan,Na Liu,Lili Li,Jiayuan Ma,Xiaoxia Jin,Lihua Duan,Youguo Chen,Genhong Cheng,Heng Yang

EP300 confers protection against acute pancreatitis via acetylating HSF1 and promoting PRKN-mediated mitophagy in pancreatic acinar cells.

EP300 通过乙酰化 HSF1 和促进胰腺腺泡细胞中 PRKN 介导的线粒体自噬，从而对急性胰腺炎起到保护作用。

期刊:Cell Communication and Signaling

影响因子:8.9

doi:10.1186/s12964-025-02604-2

Selective CBP/EP300 Bromodomain Inhibitors: Novel Epigenetic Tools to Counter TNF-α-Driven Inflammation

选择性CBP/EP300溴结构域抑制剂：对抗TNF-α驱动炎症的新型表观遗传学工具

期刊:JACS Au

影响因子:8.7

doi:10.1021/jacsau.5c00085

Gosselé, Katherine A; Latino, Irene; Laul, Eleen; Kirillova, Mariia S; Pascanu, Vlad; Carloni, Emanuele; Bedi, Rajiv K; Pizzichetti, Chiara; Caflisch, Amedeo; F González, Santiago; Nevado, Cristina

Immunology/Inflammation

Genetically predicted expression of EP300, LDHC, and TKT and risk of neurodegenerative diseases

EP300、LDHC 和 TKT 的基因预测表达与神经退行性疾病风险的关系

EP300 promotes hepatocellular carcinoma proliferation, migration and in vivo tumorigenicity revealed by integrated experimental and bioinformatic analyses

综合实验和生物信息学分析揭示EP300促进肝细胞癌的增殖、迁移和体内致瘤性

EP300/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia.

EP300/YAP1-SERPINE1 信号通路调节胆道闭锁中的胆管反应和肝纤维化。

Curcumin inhibits glycolysis via EP300 in oral squamous cell carcinoma

姜黄素通过EP300抑制口腔鳞状细胞癌中的糖酵解

EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis

EP300 通过 YY1/GPX4 轴减弱铁死亡，并刺激瘢痕疙瘩成纤维细胞的增殖、迁移和纤维化。

EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection.

EP300 缺陷会导致慢性复制压力，这是由于复制叉保护缺陷所致。

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A-Driven EP300 Expression

H3K27ac对于人类原始多能性至关重要，而这种多能性受m6A驱动的EP300表达调控。

EP300 compromises antitumor immunity by increasing SOCS1 expression

EP300 通过增加 SOCS1 表达来削弱抗肿瘤免疫力。

EP300 confers protection against acute pancreatitis via acetylating HSF1 and promoting PRKN-mediated mitophagy in pancreatic acinar cells.

EP300 通过乙酰化 HSF1 和促进胰腺腺泡细胞中 PRKN 介导的线粒体自噬，从而对急性胰腺炎起到保护作用。

Selective CBP/EP300 Bromodomain Inhibitors: Novel Epigenetic Tools to Counter TNF-α-Driven Inflammation

选择性CBP/EP300溴结构域抑制剂：对抗TNF-α驱动炎症的新型表观遗传学工具