EPAS1相关文献与解析，生知库 | 链接生命科学的每一步

Naas Stephanie, KrÃ¼ger RenÃ©, Grampp Steffen, Lauer Victoria, Kraus Andre, Naas Julia, MÃ¼ller Fabian, Gsottberger Franziska, Schiffer Mario, Wullich Bernd, Hartmann Arndt, Stemmler Marc P, SchÃ¶del Johannes

肿瘤

表观遗传

肿瘤免疫

Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis.

通过抑制 TNF/CELSR2/p65/Kla-HDAC1/EPAS1 轴，靶向间充质单核细胞衍生的巨噬细胞，以增强胶质母细胞瘤对替莫唑胺的敏感性。

期刊:Journal of Advanced Research

影响因子:13

doi:10.1016/j.jare.2025.05.032

Validation of ITPR2, DPF3, EPAS1, and PVT1-associated SNPs as biomarkers for RCC in an independent case-control cohort

在独立的病例对照队列中验证 ITPR2、DPF3、EPAS1 和 PVT1 相关 SNP 作为 RCC 生物标志物的价值

期刊:Frontiers in Medicine

影响因子:3

doi:10.3389/fmed.2026.1734511

Morales-Álvarez, C M; Jiménez-Domínguez, A C; Rios-Pelegrina, R M; Arance, E; Marín-Benesiu, F; Vázquez-Alonso, F; Martínez-González, L J; Álvarez-Cubero, M J

A novel activating somatic mutation in EPAS1, coding for HIF-2α, in a patient with a paraganglioma and sickle cell disease

在一名患有副神经节瘤和镰状细胞病的患者中，EPAS1基因（编码HIF-2α）存在一种新的激活性体细胞突变。

期刊:Archives of Endocrinology Metabolism

影响因子:2.3

doi:10.20945/2359-4292-2026-0027

Shekhda, Kalyan Mansukhbhai; Iyer, Rishi; Robledo, Mercedes; Nara, Viktorija; Luong, Tu Vinh; Caplin, Martyn; Grossman, Ashley B

HIF1A, EPAS1, and VEGFA: angiogenesis and hypoxia-related gene expression in endometrium and endometrial epithelial tumors

HIF1A、EPAS1 和 VEGFA：子宫内膜和子宫内膜上皮肿瘤中的血管生成和缺氧相关基因表达

期刊:Journal of Applied Genetics

影响因子:1.9

doi:10.1007/s13353-025-00939-7

Englert-Golon, Monika; Tokłowicz, Małgorzata; Żbikowska, Aleksandra; Sajdak, Stefan; Kotwicka, Małgorzata; Jagodziński, Paweł; Pławski, Andrzej; Andrusiewicz, Mirosław

Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High-Altitude Adaptive Genetic Variants in Sherpa Highlanders

夏尔巴高地居民中与高海拔适应性遗传变异相关的EPAS1和EGLN1 mRNA表达下调

期刊:Annals of Human Genetics

影响因子:1.2

doi:10.1111/ahg.70034

Droma, Yunden; Yue, Fengming; Ota, Masao; Kobayashi, Nobumitsu; Kitaguchi, Yoshiaki; Hanaoka, Masayuki

Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice

慢性脑低灌注通过EPAS1调控诱导小鼠静脉功能障碍

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-61614-3

Vanessa Kristina Wazny ,Aparna Mahadevan ,Nhi Nguyen ,Hannah Wee ,Ashwati Vipin ,Tammy Lam ,Kai Yi Tay ,Jia-Xiang See ,Gurveen Sandhu ,Yi Jin Leow ,Giuseppe D'Agostino ,Martin Graf ,Aravind Sivakumar ,Sichen Lin ,Nguyen Cao Thien Phuc ,James Xiao Yuan Chen ,Sarah R Langley ,Lay Teng Ang ,Kyle M Loh ,Nagaendran Kandiah ,George J Augustine ,Christine Cheung

HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY

HIF-2α/LPCAT1 通过调节 FBXW7 介导的 ACLY 泛素化来协调 ccRCC 中脂质代谢的重编程

期刊:International Journal of Biological Sciences

影响因子:8.2

doi:10.7150/ijbs.103032

Mintian Fei, Yi Zhang, Haolin Li, Qili Xu, Yu Gao, Cheng Yang, Weiyi Li, Chaozhao Liang, Baojun Wang, Haibing Xiao

EPAS1 increases SDHA to inhibit proliferation of multiple myeloma cells by restoring TCA Cycle.

EPAS1 通过恢复 TCA 循环来增加 SDHA，从而抑制多发性骨髓瘤细胞的增殖。

期刊:npj Precision Oncology

影响因子:8

doi:10.1038/s41698-025-01194-z

[Retracted] PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo

【已撤稿】负载EPAS1 siRNA的PLGA/泊洛沙姆纳米颗粒用于体外和体内治疗胰腺癌

期刊:International Journal of Molecular Medicine

影响因子:5.8

doi:10.3892/ijmm.2024.5459

Pan, Xinting; Zhu, Qingyun; Sun, Yunbo; Li, Liandi; Zhu, Yunpeng; Zhao, Zhihui; Zuo, Jianxin; Fang, Wei; Li, Kun

HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.

HIF 维持肾透明细胞癌中 EPAS1 表达的转录调控回路。

Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis.

通过抑制 TNF/CELSR2/p65/Kla-HDAC1/EPAS1 轴，靶向间充质单核细胞衍生的巨噬细胞，以增强胶质母细胞瘤对替莫唑胺的敏感性。

Validation of ITPR2, DPF3, EPAS1, and PVT1-associated SNPs as biomarkers for RCC in an independent case-control cohort

在独立的病例对照队列中验证 ITPR2、DPF3、EPAS1 和 PVT1 相关 SNP 作为 RCC 生物标志物的价值

A novel activating somatic mutation in EPAS1, coding for HIF-2α, in a patient with a paraganglioma and sickle cell disease

在一名患有副神经节瘤和镰状细胞病的患者中，EPAS1基因（编码HIF-2α）存在一种新的激活性体细胞突变。

HIF1A, EPAS1, and VEGFA: angiogenesis and hypoxia-related gene expression in endometrium and endometrial epithelial tumors

HIF1A、EPAS1 和 VEGFA：子宫内膜和子宫内膜上皮肿瘤中的血管生成和缺氧相关基因表达

Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High-Altitude Adaptive Genetic Variants in Sherpa Highlanders

夏尔巴高地居民中与高海拔适应性遗传变异相关的EPAS1和EGLN1 mRNA表达下调

Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice

慢性脑低灌注通过EPAS1调控诱导小鼠静脉功能障碍

HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY

HIF-2α/LPCAT1 通过调节 FBXW7 介导的 ACLY 泛素化来协调 ccRCC 中脂质代谢的重编程

EPAS1 increases SDHA to inhibit proliferation of multiple myeloma cells by restoring TCA Cycle.

EPAS1 通过恢复 TCA 循环来增加 SDHA，从而抑制多发性骨髓瘤细胞的增殖。

[Retracted] PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo

【已撤稿】负载EPAS1 siRNA的PLGA/泊洛沙姆纳米颗粒用于体外和体内治疗胰腺癌