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Feasibility of Intratumoral Administration With EPHB4-CAR-T Cells for the Treatment of Oral Squamous Cell Carcinoma

EPHB4-CAR-T细胞瘤内注射治疗口腔鳞状细胞癌的可行性研究

Ito, Yusuke; Suzuki, Toshihiro; Shimomura, Manami; Takenouchi, Kazumasa; Ohnuki, Kazunobu; Shoda, Kayoko; Kenmochi, Yuka; Yagyu, Shigeki; Matsuura, Kazuto; Hayashi, Ryuichi; Nakatsura, Tetsuya

EPHB4

Design and Evaluation of Eb(4)Mab-7-mG(2a): A Dual-Action Anti-EphB4 Monoclonal Antibody for Targeted Breast Cancer Therapy.

Eb(4)Mab-7-mG(2a) 的设计和评价：一种用于靶向乳腺癌治疗的双效抗 EphB4 单克隆抗体。

期刊:Cancer Science

影响因子:4.3

doi:10.1111/cas.70198

Ohishi Tomokazu, Suzuki Hiroyuki, Kaneko Mika K, Tanaka Tomohiro, Harakawa Akiko, Yoshida Junjiro, Tatsuda Daisuke, Kato Yukinari, Kawada Manabu

Hypoxia-driven circ-TBC1D1/miR-520h/EPHB4 impairs trophoblast function in unexplained recurrent spontaneous abortion

缺氧驱动的 circ-TBC1D1/miR-520h/EPHB4 会损害不明原因复发性自然流产中的滋养层功能

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-19797-8

Hua, Rong; Xie, Qinshan; Li, Jiaxu; Mo, Yi; Lin, Xiu; Huang, Chun; He, Min; Liu, Fengqiong; Huang, Yujie; Wan, Jiangfan; Sun, Yan

Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr)

正在进行的试验：针对表达EPHB4受体的恶性实体瘤的非病毒基因修饰CAR-T细胞疗法的I期研究（CARTiEr）

期刊:Frontiers in Oncology

影响因子:3.3

doi:10.3389/fonc.2025.1633324

Funasaka, Chikako; Naito, Yoichi; Kubota, Hitomi; Ishiguro, Yukiko; Fuse, Nozomu; Wakabayashi, Masashi; Sato, Akihiro; Yuda, Junichiro; Ishii, Genichiro; Suzuki, Toshihiro; Takenouchi, Kazumasa; Nakatsura, Tetsuya; Morita, Konomi; Inada, Yoichi; Tanaka, Miyuki; Nakazawa, Yozo; Yagyu, Shigeki; Doi, Toshihiko

Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization

利用孟德尔随机化方法鉴定EPHB4为子宫内膜异位症的潜在致病基因和治疗靶点

期刊:Hereditas

影响因子:2.5

doi:10.1186/s41065-025-00457-w

Ling, Shaohua; Xie, Delong; Huang, Lifang; Huang, Siqi; Tian, Chun; Huang, Liying; Chen, Rong; Qin, Li; Qin, Xiao

EPHB4

发表日期：2025

文献求助收藏

Double Genetic Diagnosis Involving MECP2 and EPHB4 in a Child with Neurodevelopmental Delay and Vascular Anomalies: A Case Report

一例伴有神经发育迟缓和血管畸形的儿童，其MECP2和EPHB4双重基因诊断：病例报告

期刊:Molecular Syndromology

影响因子:0.9

doi:10.1159/000549131

Sanri, Aslihan; Mutlu, Mehmet Burak

Refractory Diarrhea Related to EPHB4 Mutation in a Patient With Capillary Malformation-Arteriovenous Type 2 Syndrome

毛细血管畸形-动静脉2型综合征患者EPHB4基因突变引起的难治性腹泻

期刊:

影响因子:

doi:10.14309/crj.0000000000001707

McNally, Bridgette B; Liu, Margaret C; Lunsford, Tisha; Horsley-Silva, Jennifer; Swanson, Karen; Byrne, Thomas; Salomao, Marcela; Smith, Maxwell; Frazier, Rosita

EPHB4

发表日期：2025

文献求助收藏

[circ_EPHB4 synergizes with YTHDF3 to promote glioma progression via m(6)A-dependent stabilization of Wnt3]

[circ_EPHB4 与 YTHDF3 协同作用，通过 m(6)A 依赖性 Wnt3 稳定作用促进胶质瘤进展]

期刊:Nan fang yi ke da xue xue bao = Journal of Southern Medical University

影响因子:

doi:10.12122/j.issn.1673-4254.2025.11.04

Jin, Chen; Liu, Jingping; Liu, Bo; Fei, Xiyun; Liao, Yuxiang

EPHB4-RASA1 Inhibition of PIEZO1 Ras Activation Drives Lymphatic Valvulogenesis

EPHB4-RASA1抑制PIEZO1 Ras激活驱动淋巴管瓣膜形成

期刊:Circulation Research

影响因子:16.2

doi:10.1161/CIRCRESAHA.124.325383

Chen, Di; Tang, Yipei; Lapinski, Philip E; Wiggins, David; Sevick, Eva M; Davis, Michael J; King, Philip D

CircEPHB4 binds to YBX1 to upregulate MRPS16 and promotes glioma progression.

CircEPHB4 与 YBX1 结合，上调 MRPS16，促进胶质瘤进展。

Feasibility of Intratumoral Administration With EPHB4-CAR-T Cells for the Treatment of Oral Squamous Cell Carcinoma

EPHB4-CAR-T细胞瘤内注射治疗口腔鳞状细胞癌的可行性研究

Design and Evaluation of Eb(4)Mab-7-mG(2a): A Dual-Action Anti-EphB4 Monoclonal Antibody for Targeted Breast Cancer Therapy.

Eb(4)Mab-7-mG(2a) 的设计和评价：一种用于靶向乳腺癌治疗的双效抗 EphB4 单克隆抗体。

Hypoxia-driven circ-TBC1D1/miR-520h/EPHB4 impairs trophoblast function in unexplained recurrent spontaneous abortion

缺氧驱动的 circ-TBC1D1/miR-520h/EPHB4 会损害不明原因复发性自然流产中的滋养层功能

Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr)

正在进行的试验：针对表达EPHB4受体的恶性实体瘤的非病毒基因修饰CAR-T细胞疗法的I期研究（CARTiEr）

Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization

利用孟德尔随机化方法鉴定EPHB4为子宫内膜异位症的潜在致病基因和治疗靶点

Double Genetic Diagnosis Involving MECP2 and EPHB4 in a Child with Neurodevelopmental Delay and Vascular Anomalies: A Case Report

一例伴有神经发育迟缓和血管畸形的儿童，其MECP2和EPHB4双重基因诊断：病例报告

Refractory Diarrhea Related to EPHB4 Mutation in a Patient With Capillary Malformation-Arteriovenous Type 2 Syndrome

毛细血管畸形-动静脉2型综合征患者EPHB4基因突变引起的难治性腹泻

[circ_EPHB4 synergizes with YTHDF3 to promote glioma progression via m(6)A-dependent stabilization of Wnt3]

[circ_EPHB4 与 YTHDF3 协同作用，通过 m(6)A 依赖性 Wnt3 稳定作用促进胶质瘤进展]

EPHB4-RASA1 Inhibition of PIEZO1 Ras Activation Drives Lymphatic Valvulogenesis

EPHB4-RASA1抑制PIEZO1 Ras激活驱动淋巴管瓣膜形成