Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR
髓系白血病细胞对氨基肽酶抑制剂前药 CHR2863 的多因素耐药性：羧酸酯酶 1 的下调、脂质滴中的药物封存以及促存活的 ERK/Akt/mTOR 激活
期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.6169
Sue Ellen Verbrugge, Marjon Al, Yehuda G Assaraf, Sarah Kammerer, Durga M S H Chandrupatla, Richard Honeywell, Rene P J Musters, Elisa Giovannetti, Tom O'Toole, George L Scheffer, David Krige, Tanja D de Gruijl, Hans W M Niessen, Willem F Lems, Pieternella A Kramer, Rik J Scheper, Jacqueline Cloos,
信号转导
肿瘤
白血病
其它细胞
MAPK/ERK
PI3K/Akt
mTOR
EST2
