日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial

在英格兰和威尔士的急诊科,一项多中心、随机、对照、开放标签的3期临床试验比较了降钙素原检测联合NEWS2评分与基于NEWS2评分的常规治疗在识别脓毒症和启动抗生素治疗方面的效果(PRONTO):

Todd, Stacy; Euden, Joanne; Condie, Jennifer; Aston, Stephen; Barlow, Gavin; Brookes-Howell, Lucy; Carman, Julie; Carrol, Enitan D; Gilbert, Stephanie; Howard, Philip; Hood, Kerenza; Inada-Kim, Matthew; Llewelyn, Martin J; Maboshe, Wakunyambo; McGill, Fiona; Milosevic, Sarah; Nsutebu, Emmanuel; Schmidt, Paul; Tabner, Andrew; Taylor-Robinson, David; Thomas, Abin; Thomas-Jones, Emma; Welters, Ingeborg D; Pallmann, Philip; French, Neil

Mithramycin alters EWS::FLI1 DNA binding and RNA polymerase II processivity to inhibit nascent transcription

米索霉素通过改变 EWS::FLI1 与 DNA 的结合以及 RNA 聚合酶 II 的加工能力来抑制新生转录。

Kaufman, Rebecca; Flores, Guillermo; Boguslawski, Elissa A; Kinn-Gurzo, Seneca; Chassé, Maggie; Beddows, Ian; Adams, Marie; Stout, Matthew C; Gaetano, Lauren; Lopez, Raphael; Veluvolu, Sridhar; Fuller, Andrew; Kitchen-Goosen, Susan M; Tolstyka, Zachary P; Gedminas, Jenna M; Grohar, Patrick J

Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer.

青蒿素通过破坏结直肠癌中的 LSH-EWSR1 相互作用来触发钙依赖性铁死亡。

Zhu Ling, Tan Qimei, Wang Yuxia, Hong Lihong, Chen Chen, Kong Lingyi, Luo Jianguang

STAG2 loss amplifies EWS-FLI1-driven microsatellite enhancer activity promoting Ewing sarcoma aggressiveness.

STAG2 缺失会增强 EWS-FLI1 驱动的微卫星增强子活性,从而促进尤文氏肉瘤的侵袭性。

Eyunni Sanjana, Chu Shih-Chun, Guan Mary L, Louw Michaela, Young Eleanor, Carson Sandra E, Gong Jianhui, Cieslik Marcin, Chinnaiyan Arul M, Parolia Abhijit

Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma

通过对 EWS::FLI1 蛋白波动进行建模,揭示了尤文氏肉瘤肿瘤可塑性的决定因素

Veveeyan Suresh #,Christoph Hafemeister #,Andri Konstantinou,Sarah Grissenberger,Caterina Sturtzel,Martha M Zylka,Florencia Cidre-Aranaz,Andrea Wenninger-Weinzierl,Karla Queiroz,Dorota Kurek,Martin Distel,Anna Obenauf,Thomas G P Grünewald,Florian Halbritter,Heinrich Kovar,Valerie Fock

Expanding the Clinicopathologic Spectrum of EWSR1::SSX-Rearranged Sarcomas: Series of 11 Cases Including Osteosarcomas and a Novel EWSR1::SSX4 Fusion

扩展 EWSR1::SSX 重排肉瘤的临床病理谱:包括骨肉瘤和一种新型 EWSR1::SSX4 融合在内的 11 例病例系列

Gross, John M; Suster, David I; Zou, Ying; Mata, Douglas A; Amary, Fernanda; De Noon, Solange; Flanagan, Adrienne M; Wakeman, Kristina M; Wangsiricharoen, Sintawat; Dong, Fei; Lam, Suk Wai; Bovée, Judith V M G; Baltres, Aline; Pissaloux, Daniel; Pasmant, Eric; Larousserie, Frédérique; Miettinen, Markku; Hameed, Meera; Charville, Gregory W

Tissue-Specific Expression of the EWSR1::FLI1 Fusion Protein Identifies col2a1a-Positive Cells as a Source of Ewing Sarcoma-like Tumors in Zebrafish.

EWSR1::FLI1融合蛋白的组织特异性表达表明col2a1a阳性细胞是斑马鱼中尤文氏肉瘤样肿瘤的来源。

Anderson Rebecca A, Chen Xin, Oyarbide Usua, Alvarez Nicolas J, Sievers Aidan, Schwartz Gary K, Corey Seth J

Does the use of National Early Warning Scores (NEWS or NEWS2) in healthcare settings improve patient outcomes: a systematic review

在医疗保健机构中使用国家早期预警评分(NEWS 或 NEWS2)是否能改善患者预后:一项系统评价

Scott, Lauren J; Jackson, Joni; Dawson, Sarah; Knight, Thomas; Savović, Jelena

Suppressing the Aberrant Transcriptional Functionality of EWS::FLI1 Oncoprotein by Designer polyQ Fusions with Its Homologous Peptides

通过设计与同源肽融合的polyQ来抑制EWS::FLI1癌蛋白的异常转录功能

Duan, Heng-Tong; Zhang, Xiang-Le; Jiang, Lei-Lei; Hu, Hong-Yu

Circuitous Ways of EWS::FLI1 Using Circular RNA ZNF609 to Evade Translational Repression by miR-145 in Ewing's Sarcoma.

EWS::FLI1 利用环状 RNA ZNF609 绕过 miR-145 在尤文氏肉瘤中的翻译抑制的迂回方式。

Koppula Aakash, Abdelgawad Ahmed, Romero Brigette, Beringer Victoria, Parashar Vijay, Batish Mona