EXO1相关文献与解析，生知库 | 链接生命科学的每一步

Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.

全基因组 CRISPR 筛选发现 EXO1-CAF-1 通路可抑制 R 环相关的 DNA 损伤。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkag226

Nusawardhana Alexandra, Hale Anastasia, Straka Joshua, Nicolae Claudia M, Moldovan George-Lucian

Strand-independent degradation of uncoupled forks by EXO1 activates ATR and restrains synthesis

EXO1 对未偶联的复制叉进行链非依赖性降解，激活 ATR 并抑制合成。

期刊:

影响因子:

doi:10.64898/2026.03.22.666038

Grogan, Emma J; Ozua, Obehi E; Kavlashvili, Tamar; Conwell, Sara C; Dewar, James M

EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers

EXO1作为范可尼贫血症、ZRSR2和BRCA1-A复合物缺陷型癌症的治疗靶点

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-63349-7.

Marija Maric,Sandra Segura-Bayona,Raviprasad Kuthethur,Tohru Takaki,Valerie Borel,Tyler H Stanage,Miroslav P Ivanov,Nishita Parnandi,Graeme Hewitt,Rhona Millar,Carmen S Fonseca,Harshil Patel,Miriam Llorian,Scott Warchal,Michael Howell,Arnab Ray Chaudhuri,Panagiotis Kotsantis,Simon J Boulton

Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation

长吻杆菌来源的细胞外囊泡通过BRCA1/EXO1/TP53BP1调控增强口腔鳞状细胞癌的恶性程度

期刊:International Journal of Nanomedicine

影响因子:6.5

doi:10.2147/IJN.S491473

Yan, Lingjian; Wu, Fan; Jiao, Jiuyang; Maimaiti, Abudusaimi; Li, Yachong; Shao, Libin; Liang, Qixiang; Xiong, Xinxin; Qin, Zeman

Deciphering the multifaceted role of EXO1 in female-related cancers: implications for prognosis and therapeutic responsiveness

揭示EXO1在女性相关癌症中的多重作用：对预后和治疗反应的影响

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2025.1591505

Yu, Cong; Wu, Guoying

Targeting FEN1/EXO1 to enhance efficacy of PARP inhibition in triple-negative breast cancer

靶向FEN1/EXO1以增强PARP抑制剂在三阴性乳腺癌中的疗效

期刊:Translational Oncology

影响因子:4.5

doi:10.1016/j.tranon.2025.102337

Mallory I Frederick ,Elicia Fyle ,Anna Clouvel ,Djihane Abdesselam ,Saima Hassan

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration

EXO1 过表达诱导同源重组缺陷并增强 ER 阳性乳腺癌对 PARP 抑制剂的敏感性：N4BP2L2 介导的恢复调节

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2025.1695627

Sugiyama, Runa; Sedukhina, Anna S; Sato, Eri; Yamaura, Ayako; Minagawa, Kimino; Pae, Sookhee; Imai, Ena; Chawla, Ankita; Xu, Ziran; Chakraborty, Mihika; Gonoi, Satori; Yamaoka, Jotaro; Yudo, Kazuo; Tsugawa, Koichiro; Sato, Ko

EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma

EXO1是肺部驻留记忆T细胞的关键基因，对肺腺癌具有诊断和预测价值。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-88126-w

Li, Zhuoqi; Lin, Xiaoyan; Yang, Yuanhui; Tian, Mei; Zhang, Lu; Huang, Fujing; Wen, Xiao; Wei, Zhigang; Tian, Yuan

EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics

EXO1在多种癌症中的作用：通过生物信息学进行诊断、预后和免疫学分析

期刊:Discover Oncology

影响因子:2.9

doi:10.1007/s12672-025-02045-w

Liu, Zheng; Huang, Shu; Luo, Rui; Shi, Xiaomin; Xiu, Mingzhu; Wang, Yizhou; Wang, Ruiyu; Zhang, Wei; Lv, Muhan; Tang, Xiaowei

The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells.

核酸酶 EXO1 通过降解 BRCA 功能正常细胞中的新生 DNA 来促进基因组不稳定。

Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.

全基因组 CRISPR 筛选发现 EXO1-CAF-1 通路可抑制 R 环相关的 DNA 损伤。

Strand-independent degradation of uncoupled forks by EXO1 activates ATR and restrains synthesis

EXO1 对未偶联的复制叉进行链非依赖性降解，激活 ATR 并抑制合成。

EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers

EXO1作为范可尼贫血症、ZRSR2和BRCA1-A复合物缺陷型癌症的治疗靶点

Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation

长吻杆菌来源的细胞外囊泡通过BRCA1/EXO1/TP53BP1调控增强口腔鳞状细胞癌的恶性程度

Deciphering the multifaceted role of EXO1 in female-related cancers: implications for prognosis and therapeutic responsiveness

揭示EXO1在女性相关癌症中的多重作用：对预后和治疗反应的影响

Targeting FEN1/EXO1 to enhance efficacy of PARP inhibition in triple-negative breast cancer

靶向FEN1/EXO1以增强PARP抑制剂在三阴性乳腺癌中的疗效

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration

EXO1 过表达诱导同源重组缺陷并增强 ER 阳性乳腺癌对 PARP 抑制剂的敏感性：N4BP2L2 介导的恢复调节

EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma

EXO1是肺部驻留记忆T细胞的关键基因，对肺腺癌具有诊断和预测价值。

EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics

EXO1在多种癌症中的作用：通过生物信息学进行诊断、预后和免疫学分析