日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity

EZH1抑制可产生具有增强抗肿瘤活性的成熟iPSC衍生CAR T细胞

Jing, Ran; Scarfo, Irene; Najia, Mohamad Ali; Lummertz da Rocha, Edroaldo; Han, Areum; Sanborn, Michael; Bingham, Trevor; Kubaczka, Caroline; Jha, Deepak K; Falchetti, Marcelo; Schlaeger, Thorsten M; North, Trista E; Maus, Marcela V; Daley, George Q

Dual targeting of EZH2 and EZH1 drives exit of leukemia stem cells from quiescence and potentiates chemotherapy in acute myeloid leukemia

双重靶向 EZH2 和 EZH1 可促使白血病干细胞退出静止状态,并增强急性髓系白血病的化疗效果。

Akiyama, Hiroki; Nishida, Yuki; Chang, Kyung Hee; Bedoy, Andrea D; Muftuoglu, Muharrem; Ma, Wencai; Basyal, Mahesh; Hirschi, Zoe; Honma, Daisuke; Tsutsumi, Shinji; Wang, Jing; Zhang, Weiguo; Huang, Xuelin; Rampal, Raajit K; Oluwole, Olalekan O; Bixby, Dale Lee; Daver, Naval G; Andreeff, Michael

Targeting EZH1/2: tackling epigenetic resistance advances cancer therapy

靶向 EZH1/2:克服表观遗传耐药性,推进癌症治疗

Zaki, Ram Abou; El-Osta, Assam

Safety and efficacy of HH2853, a novel EZH1/2 dual inhibitor, in patients with refractory solid tumours or non-Hodgkin lymphomas: a phase I study

新型 EZH1/2 双重抑制剂 HH2853 在难治性实体瘤或非霍奇金淋巴瘤患者中的安全性和有效性:一项 I 期研究

Fan, Zhengfu; Wang, Jin; Liu, Dan; Shen, Lin; Fang, Meiyu; Johnson, Patrick; Tun, Han; Sommerhalder, David; Yang, Jilong; Yang, Yun; Munozi, Javier; Zhu, Jun; Gao, Tian; Li, Zhiming; Li, Xian'an; Ma, Qiuying; Lv, Chao; Yu, Songda; Li, Fugen; Song, Yuqin; Gong, Jifang

EZH1 Inhibition attenuates apoptosis and promotes regeneration for liver repair in acute liver failure.

EZH1抑制剂可减轻细胞凋亡,促进肝脏再生,从而修复急性肝衰竭。

You Ying, Gu Feng, Mei Meihua, Tan Ningxin, Cong Xiao, Chi Peidong, Chen Yili, Huang Junqi

A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer

Valemetostat (DS-3201b)(一种 EZH1/2 抑制剂)联合伊立替康治疗复发性小细胞肺癌患者的 I/II 期研究

Choudhury, Noura J; Lai, W Victoria; Makhnin, Alex; Heller, Glenn; Eng, Juliana; Li, Bob; Preeshagul, Isabel; Santini, Fernando C; Offin, Michael; Ng, Kenneth; Paik, Paul; Larsen, Christina; Ginsberg, Michelle S; Lau, Yvonne; Zhang, Xinyuan; Baine, Marina K; Rekhtman, Natasha; Rudin, Charles M

EZH1/2 plays critical roles in oocyte meiosis prophase I in mice

EZH1/2在小鼠卵母细胞减数分裂前期I中发挥关键作用。

Ting Jiang ,Chengxiu Zhang ,Xinjing Cao ,Yingpu Tian ,Han Cai ,Shuangbo Kong ,Jinhua Lu ,Haibin Wang ,Zhongxian Lu

CircRBM33 competitively binds miR-15a-5p to mediate EZH1 expression to ameliorate sepsis-induced acute lung injury

CircRBM33 竞争性结合 miR-15a-5p 介导 EZH1 表达以改善脓毒症引起的急性肺损伤

Jinquan Lin, Qiongying Wei, Zhipeng Fang

Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders

EZH1基因的功能获得性变异和功能丧失性变异会破坏神经发生,并导致显性和隐性神经发育障碍。

Carolina Gracia-Diaz,Yijing Zhou,Qian Yang #,Reza Maroofian #,Paula Espana-Bonilla #,Chul-Hwan Lee,Shuo Zhang,Natàlia Padilla,Raquel Fueyo,Elisa A Waxman,Sunyimeng Lei,Garrett Otrimski,Dong Li,Sarah E Sheppard,Paul Mark,Margaret H Harr,Hakon Hakonarson,Lance Rodan ,Adam Jackson ,Pradeep Vasudevan,Corrina Powel,Shehla Mohammed,Sateesh Maddirevula,Hamad Alzaidan,Eissa A Faqeih,Stephanie Efthymiou,Valentina Turchetti,Fatima Rahman , Shazia Maqbool , Vincenzo Salpietro,Shahnaz H Ibrahim , Gabriella di Rosa , Henry Houlden,Maha Nasser Alharbi , Nouriya Abbas Al-Sannaa , Peter Bauer , Giovanni Zifarelli , Conchi Estaras , Anna C E Hurst , Michelle L Thompson , Anna Chassevent , Constance L Smith-Hicks  ,Xavier de la Cruz  ,Alexander M Holtz,Houda Zghal Elloumi , M J Hajianpour , Claudine Rieubland , Dominique Braun , Siddharth Banka    ; Genomic England Research Consortium; Deborah L French,Elizabeth A Heller,Murielle Saade,Hongjun Song,Guo-Li Ming,Fowzan S Alkuraya  ,Pankaj B Agrawal  ,Danny Reinberg , Elizabeth J Bhoj,Marian A Martínez-Balbás,Naiara Akizu

EZH1/2 alteration as a potential biomarker for immune checkpoint inhibitors across multiple cancer types

EZH1/2 改变可作为多种癌症类型免疫检查点抑制剂的潜在生物标志物

Huang, Huageng; Deng, Xinyi; Yu, Le; Huang, He; Wang, Zhao; Hong, Huangming; Lin, Tongyu