FANCD2相关文献与解析，生知库 | 链接生命科学的每一步

Badra-Fajardo Nibal, Karydi Elena, Bayona-Feliu Aleix, GÃ³mez-GonzÃ¡lez BelÃ©n, Preza Ourania, Arbi Marina, Kalogeropoulou Argyro, Rantala Juha K, Taraviras Stavros, Aguilera AndrÃ©s, Lygerou Zoi

CD2

FANCD2

发表日期：2026

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The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways

DNA解旋酶HELQ与BRCA2和FANCD2介导的修复途径协同作用，促进复制叉逆转。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkag332

Dunbayev, Yerkin; Chen, Yen-Ju; Sassi, Lorenzo; Lee, Eun A; Ra, Jae Sun; Choi, Moonjung; Mukherjee, Anirban; Vasquez, Karen M; Costanzo, Vincenzo; Chi, Peter; Takata, Kei-Ichi

SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma.

SLC1A5 介导的犬尿氨酸代谢驱动 AHR-FANCD2 轴重塑染色质并诱导肺腺癌中的 T 细胞耗竭。

期刊:Cell Communication and Signaling

影响因子:8.9

doi:10.1186/s12964-026-02732-3

Zhu Yifei, Wang Haoji, Yao Yanxi, Ding Hongdou, Xu Li, Xu Xinnan

The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair.

FANCD2-FANCI 异二聚体在 DNA 双链断裂修复过程中协调染色质开放和细胞周期进程。

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2025.116830

Joyce Christine M, Bacal Julien, Chowdhury Soham P, Brown Andrew N, Wang Amy K, Cruz Carmen, Bains Kameron, Rodriguez Zachary N, McCormick Nathan J, Tzadikario Yaara, Tavasoli Katherine U, Gardner Brooke M, Richardson Chris D

Targeting FANCD2 to overcome enzalutamide resistance in prostate cancer

靶向FANCD2以克服前列腺癌中的恩扎卢胺耐药性

期刊:Cancer & Metabolism

影响因子:5.3

doi:10.1186/s40170-026-00419-4

Shi, Wenzhen; Yang, Juliang; Xu, Yue; Yang, Huijie; Hu, Junquan; Huang, Shang

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma.

白桦脂酸通过抑制 MAPK/ERK 来抑制 UBE2T 表达，从而阻断胶质母细胞瘤中 FANCI 和 FANCD2 的单泛素化。

期刊:Journal of Cellular and Molecular Medicine

影响因子:4.2

doi:10.1111/jcmm.71000

Author Correction: FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions

作者更正：FANCD2-FANCI 可检测 DNA 并识别双链与单链连接处。

期刊:Nature

影响因子:48.5

doi:10.1038/s41586-025-08763-z

Alcón, Pablo; Kaczmarczyk, Artur P; Ray, Korak Kumar; Liolios, Themistoklis; Guilbaud, Guillaume; Sijacki, Tamara; Shen, Yichao; McLaughlin, Stephen H; Sale, Julian E; Knipscheer, Puck; Rueda, David S; Passmore, Lori A

FAM111B and FANCD2, a dual expression signature, defines a distinct phenotype of pancreatic cancer

FAM111B 和 FANCD2 的双重表达特征定义了胰腺癌的一种独特表型。

期刊:Cancer Cell International

影响因子:6

doi:10.1186/s12935-025-03819-6

Wei, Fang; Li, Wanying; Zhou, Ting; Feng, Lijuan; Yuan, Xianglin; Zhang, Lihong

Correction to "Celastrol Induces Proteasomal Degradation of FANCD2 to Sensitize Lung Cancer Cells to DNA Crosslinking Agents"

更正“雷公藤内酯醇诱导FANCD2蛋白酶体降解，从而使肺癌细胞对DNA交联剂敏感”

期刊:Cancer Science

影响因子:4.3

doi:10.1111/cas.70066

Association of FANCD2, TFPI, and CD33 genes with prognosis of lung adenocarcinoma: a bioinformatics study

FANCD2、TFPI 和 CD33 基因与肺腺癌预后的相关性：一项生物信息学研究

期刊:Discover Oncology

影响因子:2.9

doi:10.1007/s12672-025-03616-7

He, Guixin; Ge, Ting; Ji, Lijiang; Guo, Yaoyao; Zhao, Ping

FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication.

FANCD2 抑制复制叉的延伸，防止在重新复制时早期复制起点出现脆弱性。

The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways

DNA解旋酶HELQ与BRCA2和FANCD2介导的修复途径协同作用，促进复制叉逆转。

SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma.

SLC1A5 介导的犬尿氨酸代谢驱动 AHR-FANCD2 轴重塑染色质并诱导肺腺癌中的 T 细胞耗竭。

The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair.

FANCD2-FANCI 异二聚体在 DNA 双链断裂修复过程中协调染色质开放和细胞周期进程。

Targeting FANCD2 to overcome enzalutamide resistance in prostate cancer

靶向FANCD2以克服前列腺癌中的恩扎卢胺耐药性

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma.

白桦脂酸通过抑制 MAPK/ERK 来抑制 UBE2T 表达，从而阻断胶质母细胞瘤中 FANCI 和 FANCD2 的单泛素化。

Author Correction: FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions

作者更正：FANCD2-FANCI 可检测 DNA 并识别双链与单链连接处。

FAM111B and FANCD2, a dual expression signature, defines a distinct phenotype of pancreatic cancer

FAM111B 和 FANCD2 的双重表达特征定义了胰腺癌的一种独特表型。

Correction to "Celastrol Induces Proteasomal Degradation of FANCD2 to Sensitize Lung Cancer Cells to DNA Crosslinking Agents"

更正“雷公藤内酯醇诱导FANCD2蛋白酶体降解，从而使肺癌细胞对DNA交联剂敏感”

Association of FANCD2, TFPI, and CD33 genes with prognosis of lung adenocarcinoma: a bioinformatics study

FANCD2、TFPI 和 CD33 基因与肺腺癌预后的相关性：一项生物信息学研究