日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-EM structures of UBA6 reveal mechanisms of E1-E2 specificity and dual FAT10/ubiquitin thioester transfer

UBA6 的冷冻电镜结构揭示了 E1-E2 特异性和双重 FAT10/泛素硫酯转移的机制

Nayak, Digant; Jia, Lijia; Dos Santos Bury, Priscila; Ruben, Eliza A; Shukla, Ankita; Nayak, Anindita; Stratton, Caleb M; Ebadi, Pirouz; Cho, Hee; Tumanova, Anna A; Varughese, Joyce T; Yuan, Lingmin; Gao, Fei; Cano, Kristin E; Davies, Christopher; Sung, Patrick; Gack, Michaela U; Wasmuth, Elizabeth V; Olsen, Shaun K

FOXC2 represses NFAT1-dependent transcription through a DNA-facilitated protein-protein interaction

FOXC2通过DNA介导的蛋白质-蛋白质相互作用抑制NFAT1依赖性转录。

Chen, Xiaojuan; Wu, Sipeng; Yue, Sitong; Zhang, Lin; Liu, Xueru; Dai, Shuyan; Li, Jun; Zhang, Huajun; Wei, Hudie; Guo, Ming; Qu, Lingzhi; Chen, Lin; Deng, Yalan; Chen, Yongheng

Loss of FAT1 drives cyclophosphamide resistance in breast cancer via the Wnt/β-Catenin pathway

FAT1 的缺失通过 Wnt/β-catenin 通路驱动乳腺癌细胞对环磷酰胺产生耐药性。

Lijing Zhong ,Dongyan Cao ,Chen Zheng ,Liyi Zhang ,Yuxuan Xu ,Shasha Zhao ,Xiao Liu ,Guiying Wei ,Gengming Niu ,Heming Xu ,Xuan Tang ,Jingyuan Wen ,Paul W R Harris ,Jian Zhang ,Aina He ,Dongxi Xiang

TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.

TGF-β1/SMAD 信号通过直接转录抑制和 FAT10 介导的蛋白酶体降解来下调肝细胞癌中的 KLF4 表达。

Protocadherin FAT1-associated membranous nephropathy after hematopoietic stem cell transplantation-a cohort study with clinico-pathological correlations

造血干细胞移植后原钙黏蛋白FAT1相关膜性肾病——一项临床病理相关性队列研究

Nackenhorst, Maja C; Milovanovic, Daniela; Schmidt, Alice; Mongera, Nicola; Köller, Maximilian; Passler, Werner; Cejka, Daniel; Kozakowski, Nicolas

LncRNA TLR8-AS1 Restricts HIV-1 Infection and Inflammation in Macrophages by Suppressing Arachidonic Acid Metabolism Through NFAT1.

LncRNA TLR8-AS1 通过 NFAT1 抑制花生四烯酸代谢,从而限制巨噬细胞中的 HIV-1 感染和炎症。

Wang Fengyi, Luo Shengrui, Zhang Junhan, Zhang Yukai, Wei Hailun, Liu Jie, Mo Chuye, Jiang Junjun, Ye Li, Yuan Zongxiang

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A-Dependent Fatty Acid Oxidation.

抑制 FAT1 可阻断代谢旁路,通过抑制 CPT1A 依赖性脂肪酸氧化来增强 TCA 循环抑制剂的抗肿瘤功效

Chen Fanghui, Yang Jianqiang, Popoola David O, Yang Fan, Liu Yajie, Wang Dongsheng, Qin Zhaohui S, Chen Zhengjia, Saba Nabil F, Chen Zhuo G, Li Yamin, Teng Yong

Redirecting microglia phenotype via inhibition of NFAT1 ameliorates deficits in mouse model of synucleinopathies

通过抑制NFAT1来改变小胶质细胞表型可以改善突触核蛋白病小鼠模型的缺陷

Iba, Michiyo; Lee, Yeon-Joo; Kwon, Somin; Horan-Portelance, Liam; Chang, Katherine; Kim, Minhyung; Landeck, Natalie; Rissman, Robert A; Lee, Seung-Jae; You, Sungyong; Kim, Changyoun

Immune factors and their role in tumor aggressiveness in glioblastoma: Atypical cadherin FAT1 as a promising target for combating immune evasion

免疫因子及其在胶质母细胞瘤侵袭性中的作用:非典型钙黏蛋白FAT1作为对抗免疫逃逸的潜在靶点

Arora, Manvi; Kundu, Archismita; Sinha, Subrata; Chosdol, Kunzang

FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway

FAT1敲低通过p-CaMKII介导的IFN通路失活增强头颈部鳞状细胞癌(HNSCC)的癌症干细胞(CSC)特性。

Wang, Jingjing; Chen, Yang; Sun, Yunqing; Liu, Hanzhe; Du, Ruixue; Wang, Xuewen; Shao, Zhe; Liu, Ke; Shang, Zhengjun