日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy

FEN1抑制剂在癌症治疗中单药治疗和联合治疗潜力的机制研究

Eeson Rajendra,Claudio A Lademann,Bethany Mason,Balca R Mardin,Lucy Armstrong,Silvia Peripolli,Julian Kreis,Timothea Konstantinou,Ulrich Pehl,Joerg Bomke,Stefanie Scharrelmann,David Perera,Birgitta Leuthner,Maria Filipa Pinto,Owen A Davis,Alessandro Galbiati,Ana Toste Rêgo,Claire L McWhirter,Elias Elinati,Ada Sala-Hojman,Julien Lefranc,Sam E Mann,Robert A Heald,Frank T Zenke,Graeme C M Smith,Helen M R Robinson,Lars T Burgdorf

Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2

PCNA 结合 FEN1 和 RNaseH2 介导的冈崎片段成熟的结构洞察

Yuhui Tian, Ningning Li, Qing Li, Ning Gao

Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels

抑制FEN1-PBX1轴可通过增加细胞内活性氧水平诱导乳腺癌细胞衰老。

Wu, Min; Wu, Benmeng; Huang, Xiaoshan; Wang, Zirui; Zhu, Miaolin; Zhu, Yaqin; Yu, Lin; Liu, Jingjing

Biological activity of Arabidopsis flap endonuclease 1 (FEN1) is modulated by nuclear factors that inhibit its aggregation

拟南芥瓣状核酸内切酶1 (FEN1) 的生物活性受核因子调控,这些核因子抑制其聚集。

Borek, Arkadiusz; Bonarek, Piotr; Kowalska, Ewa; Banaś, Agnieszka Katarzyna; Strzałka, Wojciech

Targeting FEN1/EXO1 to enhance efficacy of PARP inhibition in triple-negative breast cancer

靶向FEN1/EXO1以增强PARP抑制剂在三阴性乳腺癌中的疗效

Mallory I Frederick ,Elicia Fyle ,Anna Clouvel ,Djihane Abdesselam ,Saima Hassan

Correction: Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix

更正:蛋白质组学分析表明,FEN1 是治疗宫颈小细胞神经内分泌癌的一个有前景的靶点。

Liu, Jianbing; Zhong, Meiying; Yang, Kai; Wang, Jinjuan; Ma, Haixia; Wang, Wei; Sun, Lin; Liu, Lingling; Xu, Jing; Cui, Xiaohua; Hao, Jianqing; Li, Li

FEN1 plays a key role in the transition from HSIL to CSCC.

FEN1 在 HSIL 向 CSCC 的转变过程中起着关键作用

Zhang Fengxian, Chen Xiaomei, Chu Chenyang, Chen Meilin, Yang Ying, You Yanting, Zhou Jie, Jiang Pingping, Song Ni, Yu Yunhong, Liu Yanyan

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

Rad27/FEN1可防止冈崎片段的积累和核糖体DNA拷贝数的变化

Yamaji, Tsugumi; Katayama, Yuko; Arata, Nanase; Sasaki, Mariko

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation

XPF介导3'瓣加工,实现FEN1非依赖性的冈崎片段成熟

Li, Kejiao; Yang, Feng; Wang, Yingying; Shi, Guojun; Yan, Yao; Lei, Yi; Wang, Yixing; Zhou, Main; Sun, Haitao; Zheng, Li; Shen, Binghui

JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3

JMJD1B介导的FEN1去甲基化可使冈崎片段成熟核心酶及时切换,从而避免PARP1-LIG3介导的诱变性瓣状结构连接。

Yan, Yao; Shi, Guojun; Li, Kejiao; Lei, Yi; Wang, Yixing; Wang, Yingying; Liu, Songbai; Fernandez, Anthony; Zhou, Tingting; Wang, Evan; Zhou, Mian; Hang, Yuan; Li, Zhuo; Guo, Zhigang; Zheng, Li; Shen, Binghui