FGF21相关文献与解析，生知库 | 链接生命科学的每一步

Late-life methionine restriction attenuates neuroinflammation in Alzheimer's disease mice via FGF21 activation in a metabolism-independent manner.

晚年限制蛋氨酸摄入可通过激活 FGF21 以代谢非依赖的方式减轻阿尔茨海默病小鼠的神经炎症。

期刊:Alzheimers & Dementia

影响因子:11.1

doi:10.1002/alz.71287

Zhang Yuyu, Li Yiju, Wang Qianxu, Pang Jingxi, Wang Da, Yuan Tian, Liu Zhigang

Immunology/Inflammation

炎症

发表日期：2026

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Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system

FGF21-PVH催产素-VTA多巴胺系统对酒精摄入的负反馈调节

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2525172122

Matsui, Sho; Takahashi, Yuma; Morioka, Shuhei; Ozawa, Takaaki; Kanayama, Sachiho; Iwama, Hiroki; Geng, Lan; Umemoto, Kazuhiro; Oguri, Yasuo; Tsuzuki, Satoshi; Li, Yulong; Hikida, Takatoshi; Sasaki, Tsutomu

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours

强有力的人类遗传学证据支持FGF21对减少饮酒行为的因果作用

期刊:BMC Medicine

影响因子:8.3

doi:10.1186/s12916-026-04807-x

Cronjé, Héléne T; Hu, Sile; Gurrell, Rachel; Vujkovic, Marijana; Larsson, Susanna C; Mason, Richard; Butt, Richard; Gill, Dipender

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

FGF21介导的SIRT1上调通过FOXO3去乙酰化促进PINK1/Parkin依赖性线粒体自噬，从而延缓椎间盘退变。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70449

Wu, Zuo-Long; Ran, Rui; Xie, Qi-Qi; Zhang, Cong; Chen, Ya-Jun; Cheng, Peng; Wang, Ke-Ping; Zhang, Hai-Hong

FGF21 analogue PF-05231023 on alcohol consumption and neuronal activity in the nucleus accumbens

FGF21类似物PF-05231023对酒精摄入和伏隔核神经元活动的影响

期刊:Neuropsychopharmacology

影响因子:7.1

doi:10.1038/s41386-025-02133-z

Cooley, Bart J; Occelli Hanbury-Brown, Cassandra V; Choi, Eun A; Heller, Willow A; Lim, Alyssa W; Lawrence, Andrew J; Haber, Paul S; McNally, Gavan P; Millan, E Zayra

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.

乳酸吸收和利用的加速有助于FGF21在自然衰老小鼠中发挥神经保护作用。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70423

Ji Keru, Wei Hongde, Wang Ruguang, Wu Yutong, Li Chen, Gao Hongchang, Zhao Liangcai

Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity

GDF15 和 FGF21 与肥胖背景下的血糖状态和衰老存在不同的关联

期刊:Geroscience

影响因子:5.4

doi:10.1007/s11357-025-01830-3

Salmón-Gómez, Laura; Catalán, Victoria; Ramírez, Beatriz; Aguas-Ayesa, Maite; Rodríguez, Amaia; Becerril, Sara; Baixauli, Jorge; Gutiérrez-Medina, Sonsoles; Mugueta, Carmen; Colina, Inmaculada; Perdomo, Carolina M; Silva, Camilo; Escalada, Javier; Frühbeck, Gema; Gómez-Ambrosi, Javier

Osthole Activates FGF21 Expression by Mediating Activation of ATF4 in Human Hepatocyte HepG2 Cells

欧芹酚通过介导人肝细胞HepG2细胞中ATF4的激活来激活FGF21的表达

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms27021003

Taguchi, Akishi; Araki, Masaya; Yamashita, Tomoya; Kanazawa, Ryo; Terao, Itsuki; Suzuki, Kyohei; Tsuchimoto, Yuhei; Matsuzaka, Takashi; Sone, Hirohito; Shimano, Hitoshi; Nakagawa, Yoshimi

Lycium barbarum polysaccharides as prebiotics prevent colorectal cancer liver metastasis in non-alcoholic fatty liver disease by modulating gut microbiota-FGF21-PI3K-AKT axis.

枸杞多糖作为益生元，通过调节肠道菌群-FGF21-PI3K-AKT轴，预防非酒精性脂肪肝疾病中的结直肠癌肝转移。

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2026.1735434

Zhao Shuai, Tan Zhenyao, Suo Jiaxin, Bu Yang

Functions of FGF21 and its role in cardiac hypertrophy

FGF21的功能及其在心脏肥大中的作用

Late-life methionine restriction attenuates neuroinflammation in Alzheimer's disease mice via FGF21 activation in a metabolism-independent manner.

晚年限制蛋氨酸摄入可通过激活 FGF21 以代谢非依赖的方式减轻阿尔茨海默病小鼠的神经炎症。

Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system

FGF21-PVH催产素-VTA多巴胺系统对酒精摄入的负反馈调节

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours

强有力的人类遗传学证据支持FGF21对减少饮酒行为的因果作用

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

FGF21介导的SIRT1上调通过FOXO3去乙酰化促进PINK1/Parkin依赖性线粒体自噬，从而延缓椎间盘退变。

FGF21 analogue PF-05231023 on alcohol consumption and neuronal activity in the nucleus accumbens

FGF21类似物PF-05231023对酒精摄入和伏隔核神经元活动的影响

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.

乳酸吸收和利用的加速有助于FGF21在自然衰老小鼠中发挥神经保护作用。

Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity

GDF15 和 FGF21 与肥胖背景下的血糖状态和衰老存在不同的关联

Osthole Activates FGF21 Expression by Mediating Activation of ATF4 in Human Hepatocyte HepG2 Cells

欧芹酚通过介导人肝细胞HepG2细胞中ATF4的激活来激活FGF21的表达

Lycium barbarum polysaccharides as prebiotics prevent colorectal cancer liver metastasis in non-alcoholic fatty liver disease by modulating gut microbiota-FGF21-PI3K-AKT axis.

枸杞多糖作为益生元，通过调节肠道菌群-FGF21-PI3K-AKT轴，预防非酒精性脂肪肝疾病中的结直肠癌肝转移。