日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma

突变的FGFR1是高危神经母细胞瘤的致癌驱动因素和治疗靶点。

Werr, Lisa; Boland, Jana; Petersen, Josephine; Iglesias, Fiorella; Höppner, Stefanie; Bartenhagen, Christoph; Rosswog, Carolina; Hellmann, Anna-Maria; Kahlert, Yvonne; Hemstedt, Nadine; Ibruli, Nadliv; Dammert, Marcel A; Decarolis, Boris; Werner, Jan-Michael; Malchers, Florian; Schramm, Kathrin; Witt, Olaf; Beiske, Klaus H; Rognlien, Anne Gro Wesenberg; Gunnes, Maria Winther; Langenberg, Karin P; Molenaar, Jan; Bernkopf, Marie; Taschner-Mandl, Sabine; Hughes, Debbie; George, Sally L; Chesler, Louis; Schulte, Johannes H; Barone, Giuseppe; Capasso, Mario; Surrey, Lea F; Bagatell, Rochelle; Masliah-Planchon, Julien; Schleiermacher, Gudrun; Grüll, Holger; Westermann, Frank; Schultheis, Anne M; Büttner, Reinhard; Henssen, Anton G; Eggert, Angelika; Peifer, Martin; Shukla, Neerav N; Simon, Thorsten; Hero, Barbara; Reinhardt, H Christian; Thomas, Roman K; Fischer, Matthias

The FGFR1 N546K mutation confers resistance to pemigatinib in MLN-ZMYM2::FGFR1

FGFR1 N546K 突变赋予 MLN-ZMYM2::FGFR1 对 pemigatinib 的耐药性

Shoumariyeh, Khalid; Haug, Stefan; Schwaab, Juliana; Pfeil, Julie K; Stappenbeck, Jannis; Schmitt-Graeff, Annette; Naumann, Nicole; Waltemode, Greta; Zeiser, Robert; Miething, Cornelius; Hofmann, Wolf-Karsten; Meggendorfer, Manja; Diederichs, Sven; Duyster, Justus; Reiter, Andreas

FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.

FGF4 激活 FGFR1 - PI3K/AKT 信号通路,增强 Clec10a 介导的细胞内髓鞘碎片处理,促进脊髓修复。

Lu Wenjie, Jiang Minghao, Zhuang Junyu, Song Jiahui, Zhou Cheng, Zhou Yangbo, Zhu Zhongwei, Wu Aimin, Sheng Sunren, Zhu Sipin, Wang Zhouguang

HMGA1 Activates FGFBP1 Transcription to Enhance Angiogenesis Induction and Tumor Progression via FGF2/FGFR1 Pathway

HMGA1通过FGF2/FGFR1通路激活FGFBP1转录,从而增强血管生成诱导和肿瘤进展。

Zhang, Zhe; Xiong, Yili; Li, Mingyang; Wang, Shengyao; Liu, Zhenxing; Wang, Guanduo; Zhang, Huanqing; Yang, Xiaojuan; Liu, Gangli; Zhang, Dongsheng; Wu, Haiwei; Huang, Shengyun

Selective deletion of FGFR1 in AgRP neurons impairs energy homeostasis under high-fat diet in mice

选择性敲除AgRP神经元中的FGFR1会损害小鼠在高脂饮食下的能量稳态。

Shookster, Daniel; O'Connell, Shea; Darshan, Patel; Landry, Taylor; Bunner, Wyatt; Jiang, Zhiying; Tong, Qingchun; Huang, Hu

FGFR1/YAP1 signaling in endothelial cells drives renal fibrosis and offers a therapeutic target

内皮细胞中的FGFR1/YAP1信号通路驱动肾纤维化,并可作为治疗靶点。

Jiang, Xin; Ren, Yafeng; Yan, Mengli; Li, Mingjing; Cao, Huixia; Shao, Fengmin

Olfactory Mucosa Mesenchymal Stem Cell-Derived Exosomes Enhance Microglia M2 Polarization via the FGFR1/PLCγ1 Axis to Alleviate Alzheimer's Disease.

嗅黏膜间充质干细胞衍生的外泌体通过 FGFR1/PLCγ1 轴增强小胶质细胞 M2 极化,从而缓解阿尔茨海默病。

Ma Ya-Nan, Wang Zijie, Liang Yuchang, Tan Guoao, Hu Xiqi, Xia Ying

Establishment and characterization of preclinical models of human gynecologic tract carcinosarcomas demonstrates targetable FGFR1 alterations

人类妇科癌肉瘤临床前模型的建立和表征表明,FGFR1 改变是可靶向的。

Wong, Nelson K Y; Fernandez, Marta Llaurado; Kim, Hannah; Praveen Kumar, Pooja; Smith, DuPreez; Key, James; Lin, Yen-Yi; Volik, Stanislav; Tong, An Nhien; Le Bihan, Stephane; Collins, Colin C; Fu, Yangxin; Xue, Hui; Wang, Y Z; Köbel, Martin; Carey, Mark S; Lee, Cheng-Han

FGF21 Exacerbates Obesity-Induced Airway Hyperresponsiveness and FGFR1-Dependent Mast Cell Activation in Mice.

FGF21 加剧肥胖诱导的小鼠气道高反应性和 FGFR1 依赖性肥大细胞活化。

Ren Lulu, Xuan Lingling, Zhang Jie, Zhang Wen, An Zhuoling

PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants

PTPN11相关的努南综合征易导致携带FGFR1变异的多灶性低级别中枢神经系统肿瘤。

Kohanbash, Gary; Ryall, Scott; Gary, Sam E; Hoffman, Lindsey M; Siddaway, Robert; Bendel, Anne E; Gripp, Karen W; Walter, Andrew W; Hansford, Jordan R; Smith, Amy A; Wang, Hong; Skaugen, John M; Tabori, Uri; Hawkins, Cynthia E; Broniscer, Alberto