5-HT相关文献与解析，生知库 | 链接生命科学的每一步

Gai, Siyu; Lin, Li; Meng, Jiyong; Wu, Yichen; Xue, Li; Xu, Chanjuan; Sun, Qian; Ricarte, Adrià; Dalton, James; Renault, Pedro; Giraldo, Jesús; Pin, Jean-Philippe; Rondard, Philippe; Liu, Jianfeng

信号转导

5-HT

发表日期：2026

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Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities

MDMA使用者的记忆缺陷与皮质变薄有关，而皮质变薄又与5-HT受体密度有关。

期刊:Brain

影响因子:11.7

doi:10.1093/brain/awaf391

Coray, Rebecca C; Beliveau, Vincent; Zimmermann, Josua; Preller, Katrin H; Wunderli, Michael; Baumgartner, Markus R; Seifritz, Erich; Stock, Ann-Kathrin; Beste, Christian; Cole, David M; Quednow, Boris B

5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.

5-HT 再摄取阻断通过重塑组蛋白血清素化诱导 BRAF(V600E) 突变黑色素瘤细胞焦亡。

期刊:Cell Reports Medicine

影响因子:10.6

doi:10.1016/j.xcrm.2025.102537

The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents

迷幻苯乙胺类化合物 25C-NBF 是一种选择性 5-HT2A 激动剂，在雄性啮齿动物中表现出精神可塑性特性和快速抗抑郁作用。

期刊:Molecular Psychiatry

影响因子:10.1

doi:10.1038/s41380-025-03341-1

Nadal-Gratacós, Núria; Puigseslloses, Pol; Guzmán, Laura; Weiss, Nicola; Pottie, Eline; Riera-Colomer, Clara; Lardeux, Virginie; Thiriet, Nathalie; Wang, Fu-Hua; Källsten, Liselott; Pérez-Esteban, Irene; Ketsela, Gabriel; Margall, Joel; Berzosa, Xavier; Pubill, David; Rodríguez-Arias, Marta; Ettcheto, Miren; Kehr, Jan; Stove, Christophe; Solinas, Marcello; Sitte, Harald H; Escubedo, Elena; López-Arnau, Raul

Targeting the 5-HT(1B)-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice

靶向 5-HT(1B)-YAP 正反馈环路可保护小鼠免受紊乱血流诱导的动脉粥样硬化。

期刊:Acta Pharmacologica Sinica

影响因子:8.4

doi:10.1038/s41401-025-01672-x

Jiang, Min-Chun; Ding, Huan-Yu; Cheng, Chak Kwong; Cai, Dong-Qin; Guan, Hai-Xia; Kuang, Jian; Ma, Ronald Ching Wan; Xia, Yin; Yao, Xiao-Qiang; Wang, Li; Huang, Yu

5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice.

小鼠背缝核谷氨酸能神经元中的 5-HT2C 受体协调疼痛和焦虑的共病。

期刊:BMC Medicine

影响因子:8.3

doi:10.1186/s12916-026-04620-6

Zhang Qi, Xie Li, Zhu Changmao, Yang Siqi, Zhang Xinying, Huang Jingyao, Wang Yuanyuan, Ji Yawei, Wu Zifeng, Huang Chaoli, Wang Di, Yang Ling, Yang Chun, Hu Suwan, Jiang Riyue

Stereoselective, sex-dependent 5-HT(2A) receptor modulation of cortical plasticity by MDMA in mice

MDMA对小鼠皮层可塑性的立体选择性、性别依赖性5-HT(2A)受体调节作用

期刊:Neuropsychopharmacology

影响因子:7.1

doi:10.1038/s41386-025-02313-x

Gaines-Smith, Maya C; Silverman, Justin M; Fiorillo, Michael; Younkin, Jason; Moore, Karah N; Maltman, Jessica L; de la Fuente Revenga, Mario; Wolstenholme, Jennifer T; Glennon, Richard A; Dukat, Małgorzata; González-Maeso, Javier

Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice

通过化学遗传学方法调控终纹床核（BNST）中的促肾上腺皮质激素释放因子（CRF）神经元，可以补偿5-HT2C受体突变小鼠在恐惧消退学习中的表型行为差异。

期刊:Translational Psychiatry

影响因子:6.2

doi:10.1038/s41398-025-03799-1

Schulte, Hannah; Böke, Hanna; Lössl, Patricia; Worm, Maria; Siveke, Ida; Herlitze, Stefan; Spoida, Katharina

Binding pose depth modulates photoswitchable ligands' efficacy at the 5-HT(2A) receptor

结合姿势深度调节光敏配体在 5-HT(2A) 受体上的效力

期刊:Communications Chemistry

影响因子:6.2

doi:10.1038/s42004-026-01936-5

Weber, Verena; Salvadori, Giacomo; Natale, Federico; Gerwe, Hubert; Decker, Michael; Carloni, Paolo; Rossetti, Giulia

Fine-tuning 5-HT(7) receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties

通过微调新型（芳氧基）乙基哌啶类化合物的5-HT(7)受体选择性、反向激动作用和代谢稳定性，探索其抗抑郁和促认知特性。

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2025.118369

Canale, Vittorio; Blicharz-Futera, Klaudia; Bijata, Monika; Cavalco, Natalie G; Partyka, Anna; Stefaniak, Matylda; Kamiński, Michał; Satała, Grzegorz; Warszycki, Dawid; Lanham, Janelle K; Gołębiowska, Joanna; Gawlik, Maciej; Smolik, Magdalena; Bijata, Krystian; Jastrzębska-Więsek, Magdalena; Kurczab, Rafał; Bojarski, Andrzej J; Walczak, Maria; McCorvy, John D; Włodarczyk, Jakub; Popik, Piotr; Zajdel, Paweł

Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT(2A)

血清素受体 5-HT(2A) 对谷氨酸受体 mGlu2 的变构激活

Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities

MDMA使用者的记忆缺陷与皮质变薄有关，而皮质变薄又与5-HT受体密度有关。

5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.

5-HT 再摄取阻断通过重塑组蛋白血清素化诱导 BRAF(V600E) 突变黑色素瘤细胞焦亡。

The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents

迷幻苯乙胺类化合物 25C-NBF 是一种选择性 5-HT2A 激动剂，在雄性啮齿动物中表现出精神可塑性特性和快速抗抑郁作用。

Targeting the 5-HT(1B)-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice

靶向 5-HT(1B)-YAP 正反馈环路可保护小鼠免受紊乱血流诱导的动脉粥样硬化。

5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice.

小鼠背缝核谷氨酸能神经元中的 5-HT2C 受体协调疼痛和焦虑的共病。

Stereoselective, sex-dependent 5-HT(2A) receptor modulation of cortical plasticity by MDMA in mice

MDMA对小鼠皮层可塑性的立体选择性、性别依赖性5-HT(2A)受体调节作用

Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice

通过化学遗传学方法调控终纹床核（BNST）中的促肾上腺皮质激素释放因子（CRF）神经元，可以补偿5-HT2C受体突变小鼠在恐惧消退学习中的表型行为差异。

Binding pose depth modulates photoswitchable ligands' efficacy at the 5-HT(2A) receptor

结合姿势深度调节光敏配体在 5-HT(2A) 受体上的效力

Fine-tuning 5-HT(7) receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties

通过微调新型（芳氧基）乙基哌啶类化合物的5-HT(7)受体选择性、反向激动作用和代谢稳定性，探索其抗抑郁和促认知特性。