FURIN相关文献与解析，生知库 | 链接生命科学的每一步

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor.

衰老细胞的促炎分泌组可通过 HIF2A 依赖性上调和 FURIN 依赖性切割 ANGPTL4 分泌因子来控制。

Makulyte Gabriela, Safwan-Zaiter Hasan, Goehrig Delphine, Huna Anda, Mangelinck AdÃ¨le, Mikawa Takumi, Palazzo Alberta, Moudombi Lyvia, Medard Jean-Jacques, Chanal Marie, Lecot PacÃ´me, Michallet Marie-CÃ©cile, Gavard Julie, Adnot Serge, Dubus Pierre, Kondoh Hiroshi, Mann Carl, Tan Nguan Soon, Bertolino Philippe, Flaman Jean-Michel, Bernard David

衰老

The chaperone GRP94 interacts with the proprotein convertase furin and regulates TGF-beta maturation in human primary M2 macrophages.

分子伴侣 GRP94 与前蛋白转化酶 furin 相互作用，调节人类原代 M2 巨噬细胞中 TGF-β 的成熟。

期刊:Cell Death Discovery

影响因子:7

doi:10.1038/s41420-025-02866-2

Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-Î²/ERK Signaling Pathway.

Furin 通过 TGF-β/ERK 信号通路驱动结直肠癌进展和化疗耐药性。

期刊:Cells

影响因子:5.2

doi:10.3390/cells15010043

Poyil Pratheesh Kumar, Siraj Abdul K, Parvathareddy Sandeep Kumar, Begum Rafia, Naidu Padmanaban Annaiyappa, Thangavel Saravanan, Alobaisi Khadija, Azam Saud, Al-Dayel Fouad, Al-Kuraya Khawla S

Dysregulation of FURIN and Other Proprotein Convertase Genes in the Progression from HPV Infection to Cancer

HPV感染发展为癌症过程中FURIN和其他前蛋白转化酶基因的失调

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26020461

Izaguirre, Gonzalo; Zirou, Natalia; Meyers, Craig

Association of Single-Nucleotide Polymorphisms on FURIN and EPHA2 Genes with the Risk and Prognosis of Undifferentiated Nasopharyngeal Cancer

FURIN 和 EPHA2 基因单核苷酸多态性与未分化鼻咽癌风险和预后的相关性

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26178486

Hares, Seddam; Hamizi, Kamel; Rahab, Hamza; Bounneche, Maewa Hibatouallah; Aouidane, Souhila; Mansoura, Leila; Denni, Manel; Mallem, Wissem; Belaaloui, Ghania

A prognostic model for lung adenocarcinoma based on cuproptosis and disulfidptosis related genes revealing the key prognostic role of FURIN

基于铜凋亡和二硫键凋亡相关基因的肺腺癌预后模型揭示了FURIN的关键预后作用

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-90653-5

You, Jianhang; Yu, Qing; Chen, Ronghui; Li, Jianlin; Zhao, Tao; Lu, Zhong

Activation of renal epithelial Na+ channels (ENaC) in infants with congenital heart disease

先天性心脏病婴儿肾上皮 Na+ 通道 (ENaC) 的激活

期刊:Frontiers in Pediatrics

影响因子:2.1

doi:10.3389/fped.2024.1338672

Laura A Ortmann, Shyam Nandi, Yu-Long Li, Hong Zheng, Kaushik P Patel

1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage

1,25-二羟基维生素 D3 调节弗林蛋白酶介导的 FGF23 裂解

期刊:JCI Insight

影响因子:6.3

doi:10.1172/jci.insight.168957

Han Xie, Isinsu Bastepe, Wen Zhou, Birol Ay, Zara Ceraj, Ignacio A Portales-Castillo, Eva S Liu, Sherri-Ann M Burnett-Bowie, Harald Jüppner, Eugene P Rhee, Murat Bastepe, Petra Simic

Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus

冠状动脉疾病易感基因位点上FURIN表达的等位基因特异性表观遗传调控

期刊:Cells

影响因子:5.1

doi:10.3390/cells12131681

Wei Yang,Junjun Cao,David G McVey,Shu Ye

Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.

脑内 FURIN 缺乏会通过 ITGAV 成熟损害星形胶质细胞的脂质自噬。

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor.

衰老细胞的促炎分泌组可通过 HIF2A 依赖性上调和 FURIN 依赖性切割 ANGPTL4 分泌因子来控制。

The chaperone GRP94 interacts with the proprotein convertase furin and regulates TGF-beta maturation in human primary M2 macrophages.

分子伴侣 GRP94 与前蛋白转化酶 furin 相互作用，调节人类原代 M2 巨噬细胞中 TGF-β 的成熟。

Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-Î²/ERK Signaling Pathway.

Furin 通过 TGF-β/ERK 信号通路驱动结直肠癌进展和化疗耐药性。

Dysregulation of FURIN and Other Proprotein Convertase Genes in the Progression from HPV Infection to Cancer

HPV感染发展为癌症过程中FURIN和其他前蛋白转化酶基因的失调

Association of Single-Nucleotide Polymorphisms on FURIN and EPHA2 Genes with the Risk and Prognosis of Undifferentiated Nasopharyngeal Cancer

FURIN 和 EPHA2 基因单核苷酸多态性与未分化鼻咽癌风险和预后的相关性

A prognostic model for lung adenocarcinoma based on cuproptosis and disulfidptosis related genes revealing the key prognostic role of FURIN

基于铜凋亡和二硫键凋亡相关基因的肺腺癌预后模型揭示了FURIN的关键预后作用

Activation of renal epithelial Na+ channels (ENaC) in infants with congenital heart disease

先天性心脏病婴儿肾上皮 Na+ 通道 (ENaC) 的激活

1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage

1,25-二羟基维生素 D3 调节弗林蛋白酶介导的 FGF23 裂解

Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus

冠状动脉疾病易感基因位点上FURIN表达的等位基因特异性表观遗传调控