日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Trastuzumab deruxtecan efficacy, FcRn-facilitated penetration of the blood-tumor barrier, and distribution to tumor cells in HER2+ brain metastasis model systems

曲妥珠单抗德鲁替康的疗效、FcRn介导的血肿瘤屏障穿透以及在HER2阳性脑转移模型系统中向肿瘤细胞的分布

Khan, Imran; Kumar, Dinesh; Zhang, Wei; Difilippantonio, Simone; Robinson, Christina; Wei, Debbie; Lipkowitz, Stanley; Lake, Ross; Fleming, Ronald; Steeg, Patricia S

Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates

优化人源FcRn小鼠模型以改进抗体候选药物的药代动力学评价

Christianson, Gregory; Howard, Zachary M; Kenney, Samantha; Lowell, Emily; Bethur, Nijaguna; Roopenian, Derry; Gonzalo-Gil, Elena

Integrative structural insights into the IgG-FcRn interactions revealed by engineered FcRn-immobilized affinity chromatography

通过工程化FcRn固定化亲和层析法揭示IgG-FcRn相互作用的整合结构信息

Kiyoshi, Masato; Suzuki, Takuo; Inoue, Naruaki; Otake, Ryoko; Yumoto, Tatsuya; Hirono, Linko; Terao, Yosuke; Shibata, Hiroko; Ide, Teruhiko; Nagatoishi, Satoru; Tsumoto, Kouhei; Ishii-Watabe, Akiko

CSL305: A Dual Functional Therapeutic Antibody Targeting Complement C2 and FcRn

CSL305:一种靶向补体C2和FcRn的双功能治疗性抗体

Wymann, Sandra; Morales, Rodrigo A V; Toh, Wei Hong; Remlinger, Jana; Guse, Kirsten; Ghai, Rajesh; Pestel, Sabine; Sansome, Georgina; Chen, Chao-Guang; Rayzman, Veronika; Chia, Jenny; Quek, Adam J; Gorman, Michael A; Halder, Partho; Powers, Glenn; Ruthsatz, Tanja; Parker, Michael W; Rowe, Tony; Vyas, Sharon; Verhagen, Anne M; Hardy, Matthew P

Recombinant Human IgG1-Hexamer Reduces Pathogenic Autoantibodies in the K/BxN Mouse Model of Arthritis Independent of FcRn.

重组人 IgG1-六聚体可降低 K/BxN 关节炎小鼠模型中的致病性自身抗体,且不依赖于 FcRn。

Lewis Bonnie J B, Almizraq Ruqayyah J, Cen Selena, Binnington Beth, Frias Boligan Kayluz, Spirig Rolf, Käsermann Fabian, Dunn Shannon E, Branch Donald R

Perinatal Antibiotic Timing Impairs Maternal IgG Transfer via FcRn and Shapes the Neonatal Gut Microbiome in Mice

围产期抗生素使用时机损害母体通过FcRn途径的IgG转移,并影响小鼠新生儿肠道微生物群。

Ding, Yanan; Liu, Ali; Ma, Bingbing; Zhang, Huiqun; Zhang, Chunmei; Li, Junmin; Han, Jincheng; Shi, Chuanxin

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti-AChR Antibody-Positive Myasthenia Gravis: FGF-19 as a Novel Biomarker

Olink蛋白质组学分析揭示抗AChR抗体阳性重症肌无力患者对FcRn阻断的异质性反应:FGF-19作为一种新型生物标志物

Luo, Tiancheng; Peng, Deyou; Zhang, Zhouao; Yang, Mingjin; Guo, Xinyan; Ma, Tianyu; Huang, Xiaoyu; Xu, Mingming; Fu, Linlin; Zhang, Yong

Prediction of Monoclonal Antibodies Pharmacokinetics in Human: Identification of a Reference Neonatal Fc Receptor (FcRn) Binding Affinity Using Physiologically Based Pharmacokinetic (PBPK) Modeling

预测人体单克隆抗体药代动力学:利用生理药代动力学(PBPK)模型鉴定参考新生儿Fc受体(FcRn)结合亲和力

Benamara, Salih; Sjögren, Erik; Gattacceca, Florence; Chenel, Marylore; Deslandes, Antoine; Nguyen, Laurent; Teutonico, Donato

Quantitative Prediction of Human Pharmacokinetics for Fc-Engineered Therapeutic Monoclonal Antibodies With Increased FcRn Binding Mutations After Subcutaneous Injection

皮下注射后,FcRn结合突变增强的Fc工程化治疗性单克隆抗体的人体药代动力学定量预测

Haraya, Kenta; Kuramochi, Taichi

The Effect of FcRn Binding on Ocular Disposition of Monoclonal Antibodies

FcRn结合对单克隆抗体眼内分布的影响

Naware, Sanika; Kulkarni, Saurav; Salvi, Sahil; Patel, Dhvani; Shah, Dhaval K