日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform

Apo 和 Aβ46 结合的 γ-分泌酶结构有助于了解 APH-1B 异构体对淀粉样蛋白 β 的处理

Ivica Odorčić, Mohamed Belal Hamed, Sam Lismont, Lucía Chávez-Gutiérrez, Rouslan G Efremov

Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset

阿尔茨海默病引起的 PSEN1 变异产生的 Aβ 谱可确定突变的致病性并预测发病年龄

Dieter Petit #, Sara Gutiérrez Fernández #, Katarzyna Marta Zoltowska, Thomas Enzlein, Natalie S Ryan, Antoinette O'Connor, Maria Szaruga, Elizabeth Hill, Rik Vandenberghe, Nick C Fox, Lucía Chávez-Gutiérrez

Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP

咪唑类 γ-分泌酶调节剂靶向酶-底物界面可激活 γ-分泌酶并稳定其与 APP 的相互作用

Dieter Petit #, Manuel Hitzenberger #, Matthias Koch, Sam Lismont, Katarzyna Marta Zoltowska, Thomas Enzlein, Carsten Hopf, Martin Zacharias, Lucía Chávez-Gutiérrez

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

四跨膜蛋白 6:多囊泡体的关键蛋白,决定外泌体的释放和淀粉样蛋白前体片段的溶酶体降解

Francesc X Guix, Ragna Sannerud, Fedor Berditchevski, Amaia M Arranz, Katrien Horré, An Snellinx, Amantha Thathiah, Takaomi Saido, Takashi Saito, Sundaresan Rajesh, Michael Overduin, Samir Kumar-Singh, Enrico Radaelli, Nikky Corthout, Julien Colombelli, Sébastien Tosi, Sebastian Munck, Isabel H Sala

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex

早老素跨膜结构域 8 保守的 AXXXAXXXG 基序是 γ-分泌酶复合物活性所必需的

Claudia Marinangeli, Bernadette Tasiaux, Rémi Opsomer, Salim Hage, Alejandro O Sodero, Ilse Dewachter, Jean Noël Octave, Steven O Smith, Stefan N Constantinescu, Pascal Kienlen-Campard

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

脂肪细胞分化蛋白 APMAP 是大脑中 Aβ 产生的内源性抑制剂

Sebastien Mosser, Jean-René Alattia, Mitko Dimitrov, Alexandre Matz, Justine Pascual, Bernard L Schneider, Patrick C Fraering

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes

阿尔茨海默病相关的早老素-1 突变导致纯化的 γ-分泌酶复合物活性急剧丧失

Matthias Cacquevel, Lorène Aeschbach, Jemila Houacine, Patrick C Fraering

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate

BRI2 通过干扰分泌酶与底物的对接来抑制淀粉样β肽前体蛋白的加工

Shuji Matsuda, Luca Giliberto, Yukiko Matsuda, Eileen M McGowan, Luciano D'Adamio