53BP1相关文献与解析，生知库 | 链接生命科学的每一步

Kito Yuki, GonzÃ¡lez-Robles Tania J, Kaisari Sharon, Pae Juhee, Garcia Sheena Faye, Ortiz-Pacheco Juliana, Ueberheide Beatrix, Marzio Antonio, RÃ³na Gergely, Pagano Michele

53BP1

MCL1

发表日期：2026

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WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1.

WTAP 通过 m6A 依赖性调节 TP53BP1 促进 PDLSC 衰老和损害成骨分化，从而促进牙周炎的发病机制。

期刊:Immunity Inflammation and Disease

影响因子:2.7

doi:10.1002/iid3.70335

[Expression of Concern] Insulin-like growth factor-1 receptor knockdown enhances radiosensitivity via the HIF-1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells

【关注事项】胰岛素样生长因子-1受体敲低通过HIF-1α通路增强放射敏感性，并减弱人肺鳞状细胞癌细胞中ATM/H2AX/53BP1 DNA修复的激活。

期刊:Oncology Letters

影响因子:2.2

doi:10.3892/ol.2026.15543

Liu, Xiaoxing; Chen, Haiyan; Xu, Xin; Ye, Ming; Cao, Hongbin; Xu, Lei; Hou, Yanli; Tang, Jianmin; Zhou, Di; Bai, Yongrui; Ma, Xiumei

Time-dependent 53BP1 foci kinetics in X-irradiated human hair follicle dermal papilla cells

X射线照射的人毛囊真皮乳头细胞中53BP1聚焦动力学随时间的变化

期刊:Journal of Radiation Research

影响因子:2

doi:10.1093/jrr/rrag005

Hanamiya, Daisuke; Etani, Reo; Ojima, Mitsuaki

The glycine-arginine-rich motif of 53BP1 modulates RNA interactions necessary for its liquid-liquid phase separation during DNA Damage Response

53BP1 中富含甘氨酸-精氨酸的基序调节 RNA 相互作用，这对于其在 DNA 损伤反应过程中发生液-液相分离至关重要。

期刊:

影响因子:

doi:10.64898/2026.01.30.702603

Terraneo, Federica; Ceccon, Marta; Sapkota, Oscar; Zheng, Tongyin; Brizioli, Matteo; Dello Stritto, Angela; Cummings, Samara; Codispoti, Simone; Ossolengo, Giuseppe; Orsenigo, Fabrizio; Magni, Serena; Gottinger, Andrea; Mattevi, Andrea; Fuxreiter, Monika; Fawzi, Nicolas L; Lottersberger, Francisca; Giavazzi, Fabio; d'Adda di Fagagna, Fabrizio

Fidelity-Ensuring Consistency of Mitosis is Safeguarded by the 53BP1-USP28-p53 Pathway

53BP1-USP28-p53通路保障有丝分裂的一致性，从而维护细胞的保真度。

期刊:

影响因子:

doi:10.64898/2026.03.16.712228

Shulman, Avital; Ozaki, Kanako; Chang, Lukas R; Hoong, Eden; Bryan Tsou, Meng-Fu

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

活性氧水平升高可驱动ATRX缺失型癌症中端粒的替代延长途径。

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkaf061

Tomas Goncalves ，Siobhan Cunniffe ，Tiffany S Ma ，Natalie Mattis ，Andrew W Rose ，Thomas Kent ，David R Mole ，Helene E B Geiller ，Linda van Bijsterveldt ，Timothy C Humphrey ，Ester M Hammond ，Richard J Gibbons ，David Clynes ，Anna M Rose

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.

53BP1-RIF1 和 DNA-PKcs 表现出不同的遗传相互作用，导致不同的染色体断裂修复结果。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-65329-3

Makins Kaela, Cisneros-Aguirre Metztli, Lopezcolorado Felicia Wednesday, Stark Jeremy M

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization.

与癌症相关的 USP28 错义突变会破坏 53BP1 相互作用和 p53 稳定性。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-66341-3

Belal Hazrat, Ng Esther Feng Ying, Ohta Midori, Meitinger Franz

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

PALB2 和 53BP1 调控切除后同源重组 DNA 修复

期刊:Molecular Cell

影响因子:14.5

doi:10.1016/j.molcel.2025.07.003

Yifan Wang ,Yan Coulombe ,Wei-Ting Yueh ,Gregory D Conway ,Larissa Milano ,David J Glass ,Mélissa Thomas ,Amélie Rodrigue ,Joseph Nacson ,Dongbo Lu ,Andrea J Bernhardy ,Robert G Betsch ,Alyssa I Russo ,Gamal A Elfar ,Kathy Q Cai ,Joseph R Testa ,Mark Andrake ,Roland Dunbrack ,Gaorav P Gupta ,Bing Xia ,Eloise Dray ,Jean-Yves Masson ,Neil Johnson

GMCL1 controls 53BP1 stability and modulates taxane sensitivity.

GMCL1 控制 53BP1 的稳定性并调节紫杉烷类药物的敏感性。

WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1.

WTAP 通过 m6A 依赖性调节 TP53BP1 促进 PDLSC 衰老和损害成骨分化，从而促进牙周炎的发病机制。

[Expression of Concern] Insulin-like growth factor-1 receptor knockdown enhances radiosensitivity via the HIF-1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells

【关注事项】胰岛素样生长因子-1受体敲低通过HIF-1α通路增强放射敏感性，并减弱人肺鳞状细胞癌细胞中ATM/H2AX/53BP1 DNA修复的激活。

Time-dependent 53BP1 foci kinetics in X-irradiated human hair follicle dermal papilla cells

X射线照射的人毛囊真皮乳头细胞中53BP1聚焦动力学随时间的变化

The glycine-arginine-rich motif of 53BP1 modulates RNA interactions necessary for its liquid-liquid phase separation during DNA Damage Response

53BP1 中富含甘氨酸-精氨酸的基序调节 RNA 相互作用，这对于其在 DNA 损伤反应过程中发生液-液相分离至关重要。

Fidelity-Ensuring Consistency of Mitosis is Safeguarded by the 53BP1-USP28-p53 Pathway

53BP1-USP28-p53通路保障有丝分裂的一致性，从而维护细胞的保真度。

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

活性氧水平升高可驱动ATRX缺失型癌症中端粒的替代延长途径。

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.

53BP1-RIF1 和 DNA-PKcs 表现出不同的遗传相互作用，导致不同的染色体断裂修复结果。

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization.

与癌症相关的 USP28 错义突变会破坏 53BP1 相互作用和 p53 稳定性。

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

PALB2 和 53BP1 调控切除后同源重组 DNA 修复