日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A non-canonical role for HIF-1α: redirecting DGCR8 to the RNA exosome for snoRNA degradation and translational modulation

HIF-1α 的非经典作用:将 DGCR8 重定向至 RNA 外泌体,以降解 snoRNA 并调节翻译。

Jie-Ning Li,Ming-Yang Wang,Chiao Lo,Laising Yen,Chien-Hung Yu,Yu-Jhen Lyu,Pai-Sheng Chen

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

PROTAC介导的HMGCR耗竭通过铁死亡重编程乳腺癌细胞的脂质代谢,从而增强光免疫疗法的疗效。

Su, Tong; Li, Guang; Guan, Yudong; Tian, Qi; Qi, Youzhi; Zhang, Yanqiu; Wei, Wenqian; Duan, Xinxin; Rui, Jiaxin; Zhu, Hongyan; Lin, Zengping; Xie, Changchuan; Xu, Zheni; Wu, Yaying; Peng, Xin; Wang, Zhenjie; Chen, Kun; Xin, Xiaoyan; Zhang, Bing

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8.

双链RNA结合蛋白DGCR8控制逆转录转座子驱动的干扰素反应激活。

Gázquez-Gutiérrez Ana, Chin Priscilla, Peris Guillermo, Gordon Katrina, Marchante Pilar G, Witteveldt Jeroen, Tristán-Ramos Pablo, Rouvière Jerome O, Knol Lisanne I, Ivens Alasdair, López-Onieva Lourdes, Estévez Antonio M, Garland William, Jensen Torben H, Heras Sara R, Macias Sara

Elevated diurnal CD36 expression disrupts the bile acid synthesis rhythm leading to cholestatic liver injury and inflammation via the HMGCR/CYP7A1 axis.

昼夜 CD36 表达升高会扰乱胆汁酸合成节律,导致胆汁淤积性肝损伤和炎症,其途径为 HMGCR/CYP7A1 轴。

Zhang Yang, Zhang Mingyang, Fu Shuning, Wang Zhenyu, Zhao Yunfei, Gong Junhua, Chen Miao, Zhang Nuo, Chen Mengyue, Ruan Xiong Z, Chen Yaxi

SGCRNA: spectral clustering-guided co-expression network analysis without scale-free constraints for multi-omic data

SGCRNA:一种无需无标度约束的多组学数据谱聚类引导共表达网络分析方法

Osone, Tatsunori; Takao, Tomoka; Otake, Shigeo; Takarada, Takeshi

Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes

人类遗传学表明,HMGCR抑制与冠状动脉疾病和2型糖尿病之间存在不同的因果通路。

Hwang, Seongwon; Karhunen, Ville; Patel, Ashish; Lockhart, Sam M; Carter, Paul; Whittaker, John C; Burgess, Stephen

The atomistic Mechanism Underlying Regulation of the GPA1 G Protein Signaling Pathway Mediated by Abscisic Acid (ABA) Phytohormone Binding to the GCR1 Plant G Protein Coupled Receptor

脱落酸(ABA)植物激素与GCR1植物G蛋白偶联受体结合介导GPA1 G蛋白信号通路调控的原子级机制

Hernández, Pedro M; Arango, Carlos A; Kim, Soo-Kyung; Jaramillo-Botero, Andrés; Goddard Iii, William A

HMGCR and Rosuvastatin Regulates GLP-1 Secretion and Expression-A Translational Study

HMGCR 和瑞舒伐他汀调节 GLP-1 的分泌和表达——一项转化研究

Miskelly, Michael G; Lindqvist, Andreas; Jujić, Amra; Hamilton, Alexander; Cowan, Elaine; Raikundalia, Sweta; Dutius Andersson, Anna-Maria; Nergård, Bent J; Del Giudice, Rita; Kryvokhyzha, Dmytro; Nilsson, Peter M; Holst, Jens Juul; Torekov, Signe Sørensen; Lagerstedt, Jens O; Gomez, Maria F; Eliasson, Lena; Mulder, Hindrik; Hedenbro, Jan; Magnusson, Martin; Wierup, Nils

Exosome-Mediated miRNA Delivery Restores Early Differentiation and Survival Programs in DGCR8-Deficient Mouse Embryonic Stem Cells

外泌体介导的miRNA递送可恢复DGCR8缺陷小鼠胚胎干细胞的早期分化和存活程序

Ha, Tae-Won; Kim, Hyun Kyu; No, Dongyue; Lee, Jeong Bin; Kim, Ahyeon; Kim, Bomi; Song, Yena; Choijamts, Munkhzul; Choi, Youngsok; Lee, Mihye; Lee, Man Ryul

DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair

DGCR8调控转录偶联核苷酸切除修复的多个过程

Watanabe, Takaaki; Yoshinami, Daiyu; Yamasaki, Hiroyuki; Tanaka, Yukiko; Ohtsuka, Masato; Taniguchi, Toshiyasu