日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα-JNK pathway

三氧化二砷和 p97 抑制剂通过靶向新生多肽和激活 ZAKα-JNK 通路协同对抗急性髓系白血病

Shufeng Xie #, Hui Liu #, Shouhai Zhu #, Zhihong Chen #, Ruiheng Wang, Wenjie Zhang, Huajian Xian, Rufang Xiang, Xiaoli Xia, Yong Sun, Jinlan Long, Yuanli Wang, Minghui Wang, Yixin Wang, Yaoyifu Yu, Zixuan Huang, Chaoqun Lu, Zhenshu Xu, Han Liu

Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group

含缬酪肽的蛋白质 (VCP/p97) 对儿童 AML 的预后不利,且与未折叠蛋白反应蛋白 IRE1 和 GRP78 呈负相关:儿童肿瘤学组的一份报告

Fieke W Hoff, Yihua Qiu, Brandon D Brown, Robert B Gerbing, Amanda R Leonti, Rhonda E Ries, Alan S Gamis, Richard Aplenc, Edward Anders Kolb, Todd A Alonzo, Soheil Meshinchi, Gaye N Jenkins, Terzah M Horton, Steven M Kornblau

Targeting N-myristoylation for therapy of B-cell lymphomas

靶向 N-肉豆蔻酰化治疗 B 细胞淋巴瘤

Erwan Beauchamp, Megan C Yap, Aishwarya Iyer, Maneka A Perinpanayagam, Jay M Gamma, Krista M Vincent, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Wei-Feng Dong, Lynne M Postovit, Kevin D Read, David W Gray, Paul G Wyatt, John R Mackey, Luc G Berthiaume

Glucose-Regulated Protein 78 in the Aqueous Humor of Patients with Diabetic Macular Edema

糖尿病性黄斑水肿患者房水中的葡萄糖调节蛋白 78

Moon Young Choi, Jin-Woo Kwon

Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy

自发性高血压大鼠心脏的代谢变化先于心脏功能障碍和左心室肥大

Jie Li, Brandon A Kemp, Nancy L Howell, James Massey, Krzysztof Mińczuk, Qiao Huang, Mahendra D Chordia, R Jack Roy, James T Patrie, Giovanni E Davogustto, Christopher M Kramer, Frederick H Epstein, Robert M Carey, Heinrich Taegtmeyer, Susanna R Keller, Bijoy K Kundu

Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women

体重正常但肥胖的年轻女性补充 Omega-3 脂肪酸后,整个月经周期的 FSH 水平降低

Jessica L Bauer, Katherine Kuhn, Andrew P Bradford, Zain A Al-Safi, Mary A Harris, Robert H Eckel, Celeste Y Robledo, Anahit Malkhasyan, Joshua Johnson, Nancy R Gee, Alex J Polotsky

High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

高 N-糖多样性对于神经元粘附至关重要,并使发育中的小脑对 N-糖基化缺陷敏感

Daniel Medina-Cano, Ekin Ucuncu, Lam Son Nguyen, Michael Nicouleau, Joanna Lipecka, Jean-Charles Bizot, Christian Thiel, François Foulquier, Nathalie Lefort, Catherine Faivre-Sarrailh, Laurence Colleaux, Ida Chiara Guerrera, Vincent Cantagrel

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

抑制综合应激反应途径可防止软骨细胞异常分化,从而减轻软骨发育不良

Cheng Wang #, Zhijia Tan #, Ben Niu, Kwok Yeung Tsang, Andrew Tai, Wilson C W Chan, Rebecca L K Lo, Keith K H Leung, Nelson W F Dung, Nobuyuki Itoh, Michael Q Zhang, Danny Chan, Kathryn Song Eng Cheah

Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema

血红素清除可减轻肺内质网应激、纤维化和肺气肿

Saurabh Aggarwal, Israr Ahmad, Adam Lam, Matthew A Carlisle, Changzhao Li, J Michael Wells, S Vamsee Raju, Mohammad Athar, Steven M Rowe, Mark T Dransfield, Sadis Matalon

A phase I clinical trial of dTCApFs, a derivative of a novel human hormone peptide, for the treatment of advanced/metastatic solid tumors

dTCApFs(一种新型人类激素肽衍生物)用于治疗晚期/转移性实体肿瘤的 I 期临床试验

Salomon M Stemmer, Ofer Benjaminov, Michael H Silverman, Uziel Sandler, Ofer Purim, Naomi Sender, Chen Meir, Pnina Oren-Apoteker, Joel Ohana, Yoram Devary