日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

PIM2抑制促进浆细胞对MCL1的依赖性,涉及整合应激反应驱动的NOXA表达。

Marion Haas ,Sabrina Cherfa ,Léa Nguyen ,Maxence Bourgoin ,Gersende Caron ,Elise Dessauge ,Tony Marchand ,Laurent Delpy ,Patrick Auberger ,Jérôme Moreaux ,Arnaud Jacquel ,Thierry Fest

BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK

BCL-B通过直接抑制BOK促进肺癌侵袭性

Palaniappan Ramesh ,Amal R Al Kadi ,Gaurav M Borse ,Maximilian Webendörfer ,Gregor Zaun ,Martin Metzenmacher ,Fabian Doerr ,Servet Bölükbas ,Balazs Hegedüs ,Smiths S Lueong ,Joelle Magne ,Beiyun Liu ,Greisly Nunez ,Martin Schuler ,Douglas R Green ,Halime Kalkavan

Functional apoptosis profiling reveals vulnerabilities in T-cell large granular lymphocytic leukemia

功能性细胞凋亡分析揭示了T细胞大颗粒淋巴细胞白血病的脆弱性

Evgenii Shumilov # ,Paolo Mazzeo # ,Marcel Trautmann ,Lena Levien ,Kerstin Menck ,Katharina Richter ,Katharina Markus ,Lena Ries ,Detlef Haase ,Elena Oberle ,Philipp Berning ,Wolfgang Hartmann ,Philipp Ströbel ,Andrea Kerkhoff ,Georg Lenz ,Gerald Wulf ,Raphael Koch

Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia

单细胞系统药理学揭示了B细胞急性淋巴细胞白血病中由发育驱动的药物反应和联合疗法

Xin Huang ,Yizhen Li ,Jingliao Zhang ,Lei Yan ,Huanbin Zhao ,Liang Ding ,Sheetal Bhatara ,Xu Yang ,Satoshi Yoshimura ,Wenjian Yang ,Seth E Karol ,Hiroto Inaba ,Charles Mullighan ,Mark Litzow ,Xiaofan Zhu ,Yingchi Zhang ,Wendy Stock ,Nitin Jain ,Elias Jabbour ,Steven M Kornblau ,Marina Konopleva ,Ching-Hon Pui ,Elisabeth Paietta ,William Evans ,Jiyang Yu ,Jun J Yang

Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

内在凋亡机制的综合分子和功能表征确定了胶质瘤的治疗弱点

Elizabeth G Fernandez, Wilson X Mai, Kai Song, Nicholas A Bayley, Jiyoon Kim, Henan Zhu, Marissa Pioso, Pauline Young, Cassidy L Andrasz, Dimitri Cadet, Linda M Liau, Gang Li, William H Yong, Fausto J Rodriguez, Scott J Dixon, Andrew J Souers, Jingyi Jessica Li, Thomas G Graeber, Timothy F Cloughesy

Selective metabolic regulations by p53 mutant variants in pancreatic cancer

胰腺癌中 p53 突变变体的选择性代谢调节

Sabrina Caporali #, Alessio Butera #, Alessia Ruzza #, Carlotta Zampieri, Marina Bantula', Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D'Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio0

Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy

基于微流控技术的动态BH3谱分析可预测抗癌治疗效果

Albert Manzano-Muñoz ,José Yeste ,María A Ortega ,Fernando Martín ,Anna López ,Jordi Rosell ,Sandra Castro ,César Serrano ,Josep Samitier ,Javier Ramón-Azcón # ,Joan Montero #

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings

Gga3缺失和与晚发性阿尔茨海默病相关的GGA3罕见变异会引发轴突肿胀中BACE1的积累。

Lomoio, Selene; Willen, Rachel; Kim, WonHee; Ho, Kevin Z; Robinson, Edward K; Prokopenko, Dmitry; Kennedy, Matthew E; Tanzi, Rudolph E; Tesco, Giuseppina

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival

GGA3介导TrkA内吞循环,从而促进Akt持续磷酸化和细胞存活。

Li, Xuezhi; Lavigne, Pierre; Lavoie, Christine

GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration

GGA3 作为一种开关,促进 Met 受体的再循环,这对于维持 ERK 活性和细胞迁移至关重要。

Parachoniak, Christine Anna; Luo, Yi; Abella, Jasmine Vanessa; Keen, James H; Park, Morag